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May-2015 Volume 11 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Article

Matrine inhibits the invasive properties of human glioma cells by regulating epithelial‑to‑mesenchymal transition

  • Authors:
    • Zhongwei Wang
    • Yi Wu
    • Yali Wang
    • Yingying Jin
    • Xiulong Ma
    • Yang Zhang
    • Hongtao Ren
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China, Department of Pathology, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215003, P.R. China
  • Pages: 3682-3686
    |
    Published online on: January 8, 2015
       https://doi.org/10.3892/mmr.2015.3167
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Abstract

Matrine is reported to be effective in tumor therapies; however, the anti‑metastatic effect and molecular mechanism(s) of matrine on glioma remain poorly understood. Therefore, the purpose of this study was to assess the effects of matrine on glioma and the associated mechanism(s). In the study, we demonstrated that matrine inhibited the proliferation of glioma cells. We also observed that matrine inhibited the migration and invasion of glioma cells at non‑toxic concentrations. Matrine also decreased the expression of E‑cadherin and increased the expression of N‑cadherin. These results suggest that the anti‑metastatic effect of matrine may be correlated with epithelial‑to‑mesenchymal transition (EMT). Moreover, matrine could reduce the phosphorylation levels of p38 and AKT proteins. In conclusion, these results suggest matrine may be a potential alternative against invasive glioma cells via the p38 MAPK and AKT signaling‑dependent inhibition of EMT.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Z, Wu Y, Wang Y, Jin Y, Ma X, Zhang Y and Ren H: Matrine inhibits the invasive properties of human glioma cells by regulating epithelial‑to‑mesenchymal transition. Mol Med Rep 11: 3682-3686, 2015.
APA
Wang, Z., Wu, Y., Wang, Y., Jin, Y., Ma, X., Zhang, Y., & Ren, H. (2015). Matrine inhibits the invasive properties of human glioma cells by regulating epithelial‑to‑mesenchymal transition. Molecular Medicine Reports, 11, 3682-3686. https://doi.org/10.3892/mmr.2015.3167
MLA
Wang, Z., Wu, Y., Wang, Y., Jin, Y., Ma, X., Zhang, Y., Ren, H."Matrine inhibits the invasive properties of human glioma cells by regulating epithelial‑to‑mesenchymal transition". Molecular Medicine Reports 11.5 (2015): 3682-3686.
Chicago
Wang, Z., Wu, Y., Wang, Y., Jin, Y., Ma, X., Zhang, Y., Ren, H."Matrine inhibits the invasive properties of human glioma cells by regulating epithelial‑to‑mesenchymal transition". Molecular Medicine Reports 11, no. 5 (2015): 3682-3686. https://doi.org/10.3892/mmr.2015.3167
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Z, Wu Y, Wang Y, Jin Y, Ma X, Zhang Y and Ren H: Matrine inhibits the invasive properties of human glioma cells by regulating epithelial‑to‑mesenchymal transition. Mol Med Rep 11: 3682-3686, 2015.
APA
Wang, Z., Wu, Y., Wang, Y., Jin, Y., Ma, X., Zhang, Y., & Ren, H. (2015). Matrine inhibits the invasive properties of human glioma cells by regulating epithelial‑to‑mesenchymal transition. Molecular Medicine Reports, 11, 3682-3686. https://doi.org/10.3892/mmr.2015.3167
MLA
Wang, Z., Wu, Y., Wang, Y., Jin, Y., Ma, X., Zhang, Y., Ren, H."Matrine inhibits the invasive properties of human glioma cells by regulating epithelial‑to‑mesenchymal transition". Molecular Medicine Reports 11.5 (2015): 3682-3686.
Chicago
Wang, Z., Wu, Y., Wang, Y., Jin, Y., Ma, X., Zhang, Y., Ren, H."Matrine inhibits the invasive properties of human glioma cells by regulating epithelial‑to‑mesenchymal transition". Molecular Medicine Reports 11, no. 5 (2015): 3682-3686. https://doi.org/10.3892/mmr.2015.3167
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