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Reduced expression of microRNA‑206 regulates cell proliferation via cyclinD2 in gliomas

  • Authors:
    • Xue Yang
    • Chuanbao Zhang
    • Tianzhu Guo
    • Ying Feng
    • Qingyang Liu
    • Yan Chen
    • Quangeng Zhang

  • View Affiliations / Copyright

    Affiliations: Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, P.R. China, Beijing Neurosurgical Institute, Beijing 100050, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 3295-3300
    |
    Published online on: January 9, 2015
       https://doi.org/10.3892/mmr.2015.3171
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Abstract

MicroRNAs are short single‑stranded non‑coding RNA molecules that function as regulators of tumor progression, including regulation of glioblastoma multiforme, which is a World Health Organization grade Ⅳ glioma. Based on the results of a microRNA microarray, which included 198 patients with glioma from the Chinese Glioma Genome Atlas data set, it was observed that microRNA‑206 (miR‑206) was downregulated in high-grade (grades Ⅲ and Ⅳ) gliomas compared with grade II gliomas. In addition, high expression of miR‑206 was associated with longer overall survival time in glioma patients. The present study aimed to investigate the biological functions of miR‑206 in glioma progression in vitro using the LN229 glioma cell line. Cell proliferation was observed to be inhibited subsequent to transfection with miR‑206. It was suggested that miR‑206 induced cell cycle G1/S phase arrest by suppressing the expression of cyclinD2. The results of the present study concluded that miR‑206 inhibits glioma progression via the regulation of cyclinD2 and that miR‑206 may be a novel biomarker with potential for use as a therapeutic target in gliomas.
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Copy and paste a formatted citation
Spandidos Publications style
Yang X, Zhang C, Guo T, Feng Y, Liu Q, Chen Y and Zhang Q: Reduced expression of microRNA‑206 regulates cell proliferation via cyclinD2 in gliomas. Mol Med Rep 11: 3295-3300, 2015.
APA
Yang, X., Zhang, C., Guo, T., Feng, Y., Liu, Q., Chen, Y., & Zhang, Q. (2015). Reduced expression of microRNA‑206 regulates cell proliferation via cyclinD2 in gliomas. Molecular Medicine Reports, 11, 3295-3300. https://doi.org/10.3892/mmr.2015.3171
MLA
Yang, X., Zhang, C., Guo, T., Feng, Y., Liu, Q., Chen, Y., Zhang, Q."Reduced expression of microRNA‑206 regulates cell proliferation via cyclinD2 in gliomas". Molecular Medicine Reports 11.5 (2015): 3295-3300.
Chicago
Yang, X., Zhang, C., Guo, T., Feng, Y., Liu, Q., Chen, Y., Zhang, Q."Reduced expression of microRNA‑206 regulates cell proliferation via cyclinD2 in gliomas". Molecular Medicine Reports 11, no. 5 (2015): 3295-3300. https://doi.org/10.3892/mmr.2015.3171
Copy and paste a formatted citation
x
Spandidos Publications style
Yang X, Zhang C, Guo T, Feng Y, Liu Q, Chen Y and Zhang Q: Reduced expression of microRNA‑206 regulates cell proliferation via cyclinD2 in gliomas. Mol Med Rep 11: 3295-3300, 2015.
APA
Yang, X., Zhang, C., Guo, T., Feng, Y., Liu, Q., Chen, Y., & Zhang, Q. (2015). Reduced expression of microRNA‑206 regulates cell proliferation via cyclinD2 in gliomas. Molecular Medicine Reports, 11, 3295-3300. https://doi.org/10.3892/mmr.2015.3171
MLA
Yang, X., Zhang, C., Guo, T., Feng, Y., Liu, Q., Chen, Y., Zhang, Q."Reduced expression of microRNA‑206 regulates cell proliferation via cyclinD2 in gliomas". Molecular Medicine Reports 11.5 (2015): 3295-3300.
Chicago
Yang, X., Zhang, C., Guo, T., Feng, Y., Liu, Q., Chen, Y., Zhang, Q."Reduced expression of microRNA‑206 regulates cell proliferation via cyclinD2 in gliomas". Molecular Medicine Reports 11, no. 5 (2015): 3295-3300. https://doi.org/10.3892/mmr.2015.3171
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