Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2015 Volume 11 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2015 Volume 11 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Use of 11C-Choline positron emission tomography/computed tomography to investigate the mechanism of choline metabolism in lung cancer

  • Authors:
    • Zhaoqin Huang
    • Jun Rui
    • Xin Li
    • Xiangjiao Meng
    • Qingwei Liu
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Radiology, People's Liberation Army 520 Hospital, Mianyang, Sichuan 621000, P.R. China, Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 3285-3290
    |
    Published online on: January 14, 2015
       https://doi.org/10.3892/mmr.2015.3200
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study was conducted to investigate the 11C‑Choline metabolic mechanism and examine the association between 11C‑Choline metabolism and uptake in different pathological types of lung cancer. A total of 18 tumor specimens and corresponding normal lung tissues were collected from patients who were diagnosed with lung cancer using 11C‑Choline positron emission tomography (PET)/computed tomography (CT) imaging between January 2007 and December 2008 at the Medical Imaging Center of the Provincial Hospital Affiliated to Shandong University. The diagnosis was further confirmed pathologically following surgery. Reverse transcription polymerase chain reaction and western blotting were used to investigate the expression of choline acetyltransferase (ChAT) and choline kinase α (ChoK) in lung cancer tissue and normal lung tissue. The 11C‑Choline PET/CT data were analyzed visually and semiquantitatively. Compared with the expression in the normal lung tissues, the mRNA and protein expression of ChAT and ChoK increased in nine and 14 of the 18 lung tumors, respectively. A total of eight of the 18 tumors exhibited significantly increased expression, while three exhibited no expression of ChoK and ChAT. All lung cancer lesions were visualized with 11C‑Choline PET/CT imaging. The phosphorylation and acetylation pathways of choline metabolism may be important in 11C‑Choline uptake and metabolism in different pathological types of lung cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

American Cancer Society. Global Cancer Facts and Figures. 2nd Edition. http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-027766.pdf. American Cancer Society; Atlanta, GA, USA: 2011

2 

Almuhaideb A, Papathanasiou N and Bomanji J: 18F-FDG PET/CT imaging in oncology. Ann Saudi Med. 31:3–13. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Baum RP, Swietaszczyk C and Prasad V: FDG-PET/CT in lung cancer: an update. Front Radiat Ther Oncol. 42:15–45. 2010. View Article : Google Scholar

4 

Schillaci O, Travascio L, Bolacchi F, Calabria F, Bruni C, Cicciò C, Guazzaroni M, Orlacchio A and Simonetti G: Accuracy of early and delayed FDG PET-CT and of contrast-enhanced CT in the evaluation of lung nodules: a preliminary study on 30 patients. Radiol Med. 114:890–906. 2009.(In English and Italian). View Article : Google Scholar : PubMed/NCBI

5 

DeGrado TR, Coleman RE, Wang S, Baldwin SW, Orr MD, Robertson CN, Polascik TJ and Price DT: Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancer. Cancer Res. 61:110–117. 2001.PubMed/NCBI

6 

Nanni C, Rubello D and Fanti S: Could choline PET play a role in malignancies other than prostate cancer? Eur J Nucl Med Mol Imaging. 35:216–218. 2008. View Article : Google Scholar

7 

Tian M, Zhang H, Oriuchi N, Higuchi T and Endo K: Comparison of 11C-choline PET and FDG PET for the differential diagnosis of malignant tumors. Eur J Nucl Med Mol Imaging. 31:1064–1072. 2004.PubMed/NCBI

8 

Picchio M, Giovannini E, Crivellaro C, Gianolli L, di Muzio N and Messa C: Clinical evidence on PET/CT for radiation therapy planning in prostate cancer. Radiother Oncol. 96:347–350. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Roivainen A, Forsback S, Grönroos T, Lehikoinen P, Kähkönen M, Sutinen E and Minn H: Blood metabolism of (methyl-11C)choline; implications for in vivo imaging with positron emission tomography. Eur J Nucl Med. 27:25–32. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Hara T: 11C-choline and 2-deoxy-2-(18F)fluoro-D-glucose in tumor imaging with positron emission tomography. Mol Imaging Biol. 4:267–273. 2002. View Article : Google Scholar

11 

Yoshimoto M, Waki A, Obata A, Furukawa T, Yonekura Y and Fujibayashi Y: Radiolabeled choline as a proliferation marker: comparison with radiolabeled acetate. Nucl Med Biol. 31:859–865. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Song P, Sekhon HS, Jia Y, Keller JA, Blusztajn JK, Mark GP and Spindel ER: Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma. Cancer Res. 63:214–221. 2003.PubMed/NCBI

13 

Song P, Sekhon HS, Proskocil B, Blusztajn JK, Mark GP and Spindel ER: Synthesis of acetylcholine by lung cancer. Life Sci. 72:2159–2168. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Pascali C, Bogni A, Itawa R, Cambie M and Bombardieri E: [11C]Methylation on a C18 Sep-Pak cartridge: a convenient way to produce [N-methyl-11C]choline. J Labelled Comp Rad. 43:195–203. 2000. View Article : Google Scholar

15 

Pieterman RM, Que TH, Elsinga PH, Pruim J, van Putten JW, Willemsen AT, Vaalburg W and Groen HJ: Comparison of (11) C-choline and (18)F-FDG PET in primary diagnosis and staging of patients with thoracic cancer. J Nucl Med. 43:167–172. 2002.PubMed/NCBI

16 

Wang T, Sun YE, Yao SL, Yu CH, Yin DY and Tian JH: Value of carbon-11 choline positron emission tomography in patients with pulmonary abnormalities. Zhonghua Wai Ke Za Zhi. 44:405–408. 2006.(In Chinese). PubMed/NCBI

17 

Khan N, Oriuchi N, Zhang H, Higuchi T, Tian M, Inoue T, Sato N and Endo K: A comparative study of 11C-choline PET and (18F)fluorodeoxyglucose PET in the evaluation of lung cancer. Nucl Med Commun. 24:359–366. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Maus AD, Pereira EF, Karachunski PI, Horton RM, Navaneetham D, Macklin K, Cortes WS, Albuquerque EX and Conti-Fine BM: Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors. Mol Pharmacol. 54:779–788. 1998.PubMed/NCBI

19 

Lam DC, Girard L, Ramirez R, Chau WS, Suen WS, Sheridan S, Tin VP, Chung LP, Wong MP, Shay JW, Gazdar AF, Lam WK and Minna JD: Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers. Cancer Res. 67:4638–4647. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Zia S, Ndoye A, Nguyen VT and Grando SA: Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells. Res Commun Mol Pathol Pharmacol. 97:243–262. 1997.PubMed/NCBI

21 

Zhang H, Tian M, Oriuchi N, Higuchi T, Watanabe H, Aoki J, Tanada S and Endo K: 11C-choline PET for the detection of bone and soft tissue tumours in comparison with FDG PET. Nucl Med Commun. 24:273–279. 2003. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Huang Z, Rui J, Li X, Meng X and Liu Q: Use of 11C-Choline positron emission tomography/computed tomography to investigate the mechanism of choline metabolism in lung cancer. Mol Med Rep 11: 3285-3290, 2015.
APA
Huang, Z., Rui, J., Li, X., Meng, X., & Liu, Q. (2015). Use of 11C-Choline positron emission tomography/computed tomography to investigate the mechanism of choline metabolism in lung cancer. Molecular Medicine Reports, 11, 3285-3290. https://doi.org/10.3892/mmr.2015.3200
MLA
Huang, Z., Rui, J., Li, X., Meng, X., Liu, Q."Use of 11C-Choline positron emission tomography/computed tomography to investigate the mechanism of choline metabolism in lung cancer". Molecular Medicine Reports 11.5 (2015): 3285-3290.
Chicago
Huang, Z., Rui, J., Li, X., Meng, X., Liu, Q."Use of 11C-Choline positron emission tomography/computed tomography to investigate the mechanism of choline metabolism in lung cancer". Molecular Medicine Reports 11, no. 5 (2015): 3285-3290. https://doi.org/10.3892/mmr.2015.3200
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Z, Rui J, Li X, Meng X and Liu Q: Use of 11C-Choline positron emission tomography/computed tomography to investigate the mechanism of choline metabolism in lung cancer. Mol Med Rep 11: 3285-3290, 2015.
APA
Huang, Z., Rui, J., Li, X., Meng, X., & Liu, Q. (2015). Use of 11C-Choline positron emission tomography/computed tomography to investigate the mechanism of choline metabolism in lung cancer. Molecular Medicine Reports, 11, 3285-3290. https://doi.org/10.3892/mmr.2015.3200
MLA
Huang, Z., Rui, J., Li, X., Meng, X., Liu, Q."Use of 11C-Choline positron emission tomography/computed tomography to investigate the mechanism of choline metabolism in lung cancer". Molecular Medicine Reports 11.5 (2015): 3285-3290.
Chicago
Huang, Z., Rui, J., Li, X., Meng, X., Liu, Q."Use of 11C-Choline positron emission tomography/computed tomography to investigate the mechanism of choline metabolism in lung cancer". Molecular Medicine Reports 11, no. 5 (2015): 3285-3290. https://doi.org/10.3892/mmr.2015.3200
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team