Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
June-2015 Volume 11 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2015 Volume 11 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Von Hippel-Lindau gene expression on the human fallopian tube epithelium during the menstrual cycle

  • Authors:
    • Yan-Yan Lu
    • Wei-Jie Zhu
    • Bao-Guo Xie
  • View Affiliations / Copyright

    Affiliations: Department of Developmental and Regenerative Biology, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, P.R. China
  • Pages: 4414-4418
    |
    Published online on: January 22, 2015
       https://doi.org/10.3892/mmr.2015.3237
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The Von Hippel-Lindau gene (VHL) is a tumor suppressor gene, which is widely expressed in kidney, lung, breast, ovary, and cervix. VHL gene mutations can induce VHL disease and tumorigenesis. However, whether this gene is expressed in the human fallopian tube has not been evaluated. The objectives of this study were to investigate whether the VHL gene is expressed in human fallopian tube, and to investigate its expression changes during the menstrual cycle. Twenty‑seven patients undergoing abdominal hysterectomy with adnexectomy for benign uterine disease were enrolled in the study. Human fallopian tubes were divided into proliferative stage (n=14) and secretory stage (n=13) according to the stage of the menstrual cycle they were isolated from. The expression of the VHL gene and protein was studied by reverse transcription-polymerase chain reaction (RT-PCR), western blotting and immunohistochemistry, respectively. The results revealed positive expression of the VHL protein in the cytoplasm of ciliated cells of the human fallopian tube. The mRNA and protein expression of VHL in the fallopian tubes was higher in the proliferative compared to the secretory phase of the menstrual cycle, but this difference was not significant (P>0.05). Overall, this study presents data on the VHL mRNA and protein expression in the human fallopian tube, which may be relevant to the process of differentiation of ciliated and secretory cells.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Croxatto HB: Physiology of gamete and embryo transport through the fallopian tube. Reprod Biomed Online. 4:160–169. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Latif F, Tory K, Gnarra J, Yao M, Duh FM, Orcutt ML, Stackhouse T, Kuzmin I, Modi W, Geil L, et al: Identification of the von Hippel-Lindau disease tumor suppressor gene. Science. 260:1317–1320. 1993. View Article : Google Scholar : PubMed/NCBI

3 

Kamada M, Suzuki K, Kato Y, Okuda H and Shuin T: von Hippel-Lindau protein promotes the assembly of actin and vinculin and inhibits cell motility. Cancer Res. 61:4184–4189. 2001.PubMed/NCBI

4 

Lu N, Hui H, Yang H, Zhao K, Chen Y, You QD and Guo QL: Gambogic acid inhibits angiogenesis through inhibiting PHD2-VHL-HIF-1α pathway. Eur J Pharm Sci. 49:220–226. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Ohh M, Park CW, Ivan M, Hoffman MA, Kim TY, Huang LE, Pavletich N, Chau V and Kaelin WG: Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol. 2:423–427. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Zhou MI, Wang H, Foy RL, Ross JJ and Cohen HT: Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent. Cancer Res. 64:1278–1286. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Schraml P, Struckmann K, Hatz F, Sonnet S, Kully C, Gasser T, Sauter G, Mihatsch MJ and Moch H: VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma. J Pathol. 196:186–193. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Shuin T, Yamasaki I, Tamura K, Okuda H, Furihata M and Ashida S: Von Hippel-Lindau disease: molecular pathological basis, clinical criteria, genetic testing, clinical features of tumors and treatment. Jpn J Clin Oncol. 36:337–343. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Rajakumar A, Doty K, Daftary A, Markovic N and Conrad KP: Expression of von Hippel Lindau (pVHL) protein in placentae from normal pregnant women and women with preeclampsia. Placenta. 27:411–421. 2006. View Article : Google Scholar

10 

Noyes RW, Hertig AT and Rock J: Dating the endometrial biopsy. Am J Obstet Gynecol. 122:262–263. 1975.PubMed/NCBI

11 

Richards FM, Schofield PN, Fleming S and Maher ER: Expression of the von Hippel-Lindau disease tumour suppressor gene during human embryogenesis. Hum Mol Genet. 5:639–644. 1996. View Article : Google Scholar : PubMed/NCBI

12 

Tang N, Mack F, Haase VH, Simon MC and Johnson RS: pVHL function is essential for endothelial extracellular matrix deposition. Mol Cell Biol. 26:2519–2530. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Davidowitz EJ, Schoenfeld AR and Burk RD: VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling. Mol Cell Biol. 21:865–874. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Schermer B, Ghenoiu C, Bartram M, Müller RU, Kotsis F, Höhne M, Kühn W, Rapka M, Nitschke R, Zentgraf H, et al: The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth. J Cell Biol. 175:547–554. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Lyons R, Saridogan E and Djahanbakhch O: The reproductive significance of human Fallopian tube cilia. Hum Reprod Update. 12:363–372. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Crow J, Amso NN, Lewin J and Shaw RW: Morphology and ultrastructure of fallopian tube epithelium at different stages of the menstrual cycle and menopause. Hum Reprod. 9:2224–2233. 1994.PubMed/NCBI

17 

Comer MT, Leese H and Southgate J: Induction of a differentiated ciliated cell phenotype in primary cultures of Fallopian tube epithelium. Hum Reprod. 13:3114–3120. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Esteban MA, Harten SK, Tran MG and Maxwell PH: Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein. J Am Soc Nephrol. 17:1801–1806. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Lutz MS and Burk RD: Primary cilium formation requires von hippel-lindau gene function in renal-derived cells. Cancer Res. 66:6903–6907. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Makrigiannakis A, Karamouti M, Petsas G, Makris N, Nikas G and Antsaklis A: The expression of receptivity markers in the fallopian tube epithelium. Histochem Cell Biol. 132:159–167. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Ohh M, Yauch RL, Lonergan KM, Whaley JM, Stemmer-Rachamimov AO, Louis DN, Gavin BJ, Kley N, Kaelin WG Jr and Iliopoulos O: The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol Cell. 1:959–968. 1998. View Article : Google Scholar : PubMed/NCBI

22 

Zhou Q, Pardo A, Königshoff M, Eickelberg O, Budinger GR, Thavarajah K, Gottardi CJ, Jones J, Varga J and Selman M: Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis. FASEB J. 25:3032–3044. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Lonser RR, Glenn GM, Walther M, Chew EY, Libutti SK, Linehan WM and Oldfield EH: von Hippel-Lindau disease. Lancet. 361:2059–2067. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Sülz L, Valenzuela JP, Salvatierra AM, Ortiz ME and Croxatto HB: The expression of alpha (v) and beta3 integrin subunits in the normal human Fallopian tube epithelium suggests the occurrence of a tubal implantation window. Hum Reprod. 13:2916–2920. 1998. View Article : Google Scholar

25 

Guo W and Giancotti FG: Integrin signalling during tumour progression. Nat Rev Mol Cell Biol. 5:816–826. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Ji Q and Burk RD: Downregulation of integrins by von Hippel-Lindau (VHL) tumor suppressor protein is independent of VHL-directed hypoxia-inducible factor alpha degradation. Biochem Cell Biol. 86:227–234. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Esteban-Barragán MA, Ávila P, Álvarez-Tejado M, Gutiérrez MD, García-Pardo Á, Sánchez-Madrid F and Landázuri MO: Role of the von Hippel-Lindau tumor suppressor gene in the formation of β1-integrin fibrillar adhesions. Cancer Res. 62:2929–2936. 2002.

28 

Mastroianni L Jr: The fallopian tube and reproductive health. J Pediatr Adolesc Gynecol. 12:121–126. 1999. View Article : Google Scholar : PubMed/NCBI

29 

Wanggren K, Lalitkumar P, Stavreus-Evers A, Stabi B and Gemzell-Danielsson K: Prostaglandin E2 and F2alpha receptors in the human Fallopian tube before and after mifepristone treatment. Mol Hum Reprod. 12:577–585. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Semenza GL: Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE. 2007:pp. cm82007, View Article : Google Scholar : PubMed/NCBI

31 

Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER and Ratcliffe PJ: The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 399:271–275. 1999. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lu Y, Zhu W and Xie B: Von Hippel-Lindau gene expression on the human fallopian tube epithelium during the menstrual cycle. Mol Med Rep 11: 4414-4418, 2015.
APA
Lu, Y., Zhu, W., & Xie, B. (2015). Von Hippel-Lindau gene expression on the human fallopian tube epithelium during the menstrual cycle. Molecular Medicine Reports, 11, 4414-4418. https://doi.org/10.3892/mmr.2015.3237
MLA
Lu, Y., Zhu, W., Xie, B."Von Hippel-Lindau gene expression on the human fallopian tube epithelium during the menstrual cycle". Molecular Medicine Reports 11.6 (2015): 4414-4418.
Chicago
Lu, Y., Zhu, W., Xie, B."Von Hippel-Lindau gene expression on the human fallopian tube epithelium during the menstrual cycle". Molecular Medicine Reports 11, no. 6 (2015): 4414-4418. https://doi.org/10.3892/mmr.2015.3237
Copy and paste a formatted citation
x
Spandidos Publications style
Lu Y, Zhu W and Xie B: Von Hippel-Lindau gene expression on the human fallopian tube epithelium during the menstrual cycle. Mol Med Rep 11: 4414-4418, 2015.
APA
Lu, Y., Zhu, W., & Xie, B. (2015). Von Hippel-Lindau gene expression on the human fallopian tube epithelium during the menstrual cycle. Molecular Medicine Reports, 11, 4414-4418. https://doi.org/10.3892/mmr.2015.3237
MLA
Lu, Y., Zhu, W., Xie, B."Von Hippel-Lindau gene expression on the human fallopian tube epithelium during the menstrual cycle". Molecular Medicine Reports 11.6 (2015): 4414-4418.
Chicago
Lu, Y., Zhu, W., Xie, B."Von Hippel-Lindau gene expression on the human fallopian tube epithelium during the menstrual cycle". Molecular Medicine Reports 11, no. 6 (2015): 4414-4418. https://doi.org/10.3892/mmr.2015.3237
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team