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Article

Fibroblast activation protein and its prognostic significance in correlation with vascular endothelial growth factor in pancreatic adenocarcinoma

  • Authors:
    • Dimitrios Patsouras
    • Kostis Papaxoinis
    • Alkiviadis Kostakis
    • Michael C. Safioleas
    • Andreas C. Lazaris
    • Polyxeni Nicolopoulou‑Stamati
  • View Affiliations / Copyright

    Affiliations: Department of GI Surgery, St. Thomas' Hospital, London SE1 7EH, United Kingdom, Gastroenterology Unit, 1st Department of Internal Medicine‑Propaedeutic, ‘Laiko’ General Hospital, Athens University Medical School, Athens GR‑11527, Greece, Center of Experimental Surgery, Biomedical Research Foundation, Academy of Athens, Athens GR‑11527, Greece, Fourth Propedeutic Department of Surgery, Athens University Medical School, Attikon Hospital of Athens, Athens GR-12462, Greece, 1st Department of Pathology, Athens University Medical School, Athens GR‑11527, Greece
  • Pages: 4585-4590
    |
    Published online on: January 27, 2015
       https://doi.org/10.3892/mmr.2015.3259
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Abstract

Fibroblast activation protein (FAP), a selective protein for tumor stromal fibroblasts, is expressed in >90% of human epithelial carcinomas. A characteristic feature of pancreatic cancer is an extensive fibrotic or desmoplastic reaction surrounding the primary tumor. The present study aimed to evaluate the expression levels of FAP and vascular endothelial growth factor (VEGF) and determine their correlation in pancreatic adenocarcinoma. Confocal laser scanning microscopy and conventional immunohistochemical analysis were used to quantify FAP and VEGF expression levels in formalin‑fixed and paraffin‑embedded tissue biopsies from 46 patients (male, 26; female, 20; mean age, 66 years; age range, 53‑80 years) with pancreatic adenocarcinoma stage IIA or IIB. The expression levels of FAP in the neoplastic and adjacent normal tissue were significantly higher in stage IIB patients, compared with stage IIA patients. FAP expression was correlated with positive lymph nodes, resulting in poor prognosis for stage IIB patients. The partial correlation coefficient between FAP and VEGF expression levels was 0.39 (P=0.007), and the two factors had an effect on patient survival. Multivariate analysis demonstrated the prognostic superiority of FAP over VEGF, which is considered to be the most consistently reproducible molecular marker with prognostic value in resected pancreatic adenocarcinoma. Due to the limited beneficial effect of current systemic therapies for pancreatic adenocarcinoma, targeting FAP may be a potential therapeutic strategy and requires further investigation.
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1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clinic. 63:11–30. 2013. View Article : Google Scholar

2 

Crist DW and Cameron JL: The current status of the Whipple operation for periampullary carcinoma. Adv Surg. 25:21–49. 1992.PubMed/NCBI

3 

Sohn TA, Yeo CJ, Cameron JL, et al: Resected adenocarcinoma of the pancreas-616 patients: results, outcomes and prognostic indicators. J Gastrointest Surg. 4:567–579. 2000. View Article : Google Scholar

4 

Cleary SP, Gryfe R, Guindi M, et al: Prognostic factors in resected pancreatic adenocarcinoma: analysis of actual 5-year survivors. J Am Coll Surg. 198:722–731. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Han SS, Jang JY, Kim SW, Kim WH, Lee KU and Park YH: Analysis of long-term survivors after surgical resection for pancreatic cancer. Pancreas. 32:271–275. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Moon HJ, An JY, Heo JS, Choi SH, Joh JW and Kim YI: Predicting survival after surgical resection for pancreatic ductal adenocarcinoma. Pancreas. 32:37–43. 2006. View Article : Google Scholar

7 

Matsuno S, Egawa S, Fukuyama S, et al: Pancreatic cancer registry in Japan: 20 years of experience. Pancreas. 28:219–230. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Whitehurst B, Flister MJ, Bagaitkar J, et al: Anti-VEGF-A therapy reduces lymphatic vessel density and expression of VEGFR-3 in an orthotopic breast tumor model. Int J Cancer. 121:2181–2191. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Christiansen A and Detmar M: Lymphangiogenesis and cancer. Genes Cancer. 2:1146–1158. 2011. View Article : Google Scholar

10 

Shinkaruk S, Bayle M, Laïn G and Déléris G: Vascular endo-thelial cell growth factor (VEGF), an emerging target for cancer chemotherapy. Curr Med Chem Anticancer Agents. 3:95–117. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Brown LF, Guidi AJ, Schnitt SJ, et al: Vascular stroma formation in carcinoma in situ, invasive carcinoma and metastatic carcinoma of the breast. Clin Cancer Res. 5:1041–1056. 1999.PubMed/NCBI

12 

Fukumura D, Xavier R, Sugiura T, et al: Tumor induction of VEGF promoter activity in stromal cells. Cell. 94:715–725. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS and Dvorak HF: Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science. 219:983–985. 1983. View Article : Google Scholar : PubMed/NCBI

14 

Dvorak HF, Sioussat TM, Brown LF, et al: Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels. J Exp Med. 174:1275–1278. 1991. View Article : Google Scholar : PubMed/NCBI

15 

Feng D, Nagy JA, Brekken RA, et al: Ultrastructural localization of the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) receptor-2 (FLK-1, KDR) in normal mouse kidney and in the hyperpermeable vessels induced by VPF/VEGF-expressing tumors and adenoviral vectors. J Histochem Cytochem. 48:545–556. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Leung DW, Cachianes G, Kuang WJ, Goeddel DV and Ferrara N: Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 246:1306–1309. 1989. View Article : Google Scholar : PubMed/NCBI

17 

Mahadevan D and Von Hoff DD: Tumor-stroma interactions in pancreatic ductal adenocarcinoma. Mol Cancer Ther. 6:1186–1197. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Ikeda N, Adachi M, Taki T, et al: Prognostic significance of angiogenesis in human pancreatic cancer. Br J Cancer. 79:1553–1563. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Itakura J, Ishiwata T, Shen B, Kornmann M and Korc M: Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer. Int J Cancer. 85:27–34. 2000. View Article : Google Scholar

20 

Fujimoto K, Hosotani R, Wada M, et al: Expression of two angiogenic factors, vascular endothelial growth factor and platelet-derived endothelial cell growth factor in human pancreatic cancer and its relationship to angiogenesis. Eur J Cancer. 34:1439–1447. 1998. View Article : Google Scholar : PubMed/NCBI

21 

Park JE, Lenter MC, Zimmermann RN, Garin-Chesa P, Old LJ and Rettig WJ: Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts. J Biol Chem. 274:36505–36512. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Garin-Chesa P, Old LJ and Rettig WJ: Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers. Proc Nat Acad Sci USA. 87:7235–7239. 1990. View Article : Google Scholar : PubMed/NCBI

23 

Scanlan MJ, Raj BK, Calvo B, et al: Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. Proc Nat Acad Sci USA. 91:5657–5661. 1994. View Article : Google Scholar : PubMed/NCBI

24 

Mueller MM and Fusenig NE: Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells. Differentiation. 70:486–497. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Liotta LA, Steeg PS and Stetler-Stevenson WG: Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell. 64:327–336. 1991. View Article : Google Scholar : PubMed/NCBI

26 

Cohen SJ, Alpaugh RK, Palazzo I, et al: Fibroblast activation protein and its relationship to clinical outcome in pancreatic adenocarcinoma. Pancreas. 37:154–158. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Goscinski MA, Suo Z, Florenes VA, Vlatkovic L, Nesland JM and Giercksky KE: FAP-alpha and uPA show different expression patterns in premalignant and malignant esophageal lesions. Ultrastruct Pathol. 32:89–96. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Henry LR, Lee HO, Lee JS, et al: Clinical implications of fibroblast activation protein in patients with colon cancer. Clin Cancer Res. 13:1736–1741. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Földes-Papp Z, Demel U and Tilz GP: Laser scanning confocal fluorescence microscopy: an overview. Int Immunopharmacol. 3:1715–1729. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Amos WB and White JG: How the confocal laser scanning microscope entered biological research. Biol Cell. 95:335–342. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Papaxoinis K, Patsouris E, Kittas C and Nicolopoulou-Stamati P: Insulinlike growth factor I receptor and estrogen receptor beta expressions are inversely correlated in colorectal neoplasms and affected by the insulin resistance syndrome. Hum Pathol. 38:1037–1046. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Mason DY, Micklem K and Jones M: Double immunofluorescence labelling of routinely processed paraffin sections. J Pathol. 191:452–461. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Hamilton SR and Aaltonen LA: Pathology and Genetics of Tumours of the Digestive System. World Health Organization Classification of Tumours. Kleihues P and Sobin LH: IARC Press; Lyon: pp. 1–250. 2000

34 

Giulianotti PC, Boggi U, Fornaciari G, et al: Prognostic value of histological grading in ductal adenocarcinoma of the pancreas. Klöppel vs TNM grading. Int J Pancreatol. 17:279–289. 1995. View Article : Google Scholar : PubMed/NCBI

35 

Edge SB, Byrd DR, Compton CC, et al: AJCC Cancer Staging Manual. 7th. Springer; New York, NY: pp. 241–249. 2010

36 

Kraman M, Bambrough PJ, Arnold JN, et al: Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. Science. 330:827–830. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Shi M, Yu DH, Chen Y, et al: Expression of fibroblast activation protein in human pancreatic adenocarcinoma and its clinicopathological significance. World J Gastroenterol. 18:840–846. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Smith RA, Tang J, Tudur-Smith C, Neoptolemos JP and Ghaneh P: Meta-analysis of immunohistochemical prognostic markers in resected pancreatic cancer. Br J Cancer. 104:1440–1451. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Kindler HL, Ioka T, Richel DJ, et al: Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study. Lancet Oncol. 12:256–262. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Spano JP, Chodkiewicz C, Maurel J, et al: Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: an open-label randomised phase II study. Lancet. 371:2101–2108. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Cirri P and Chiarugi P: Cancer associated fibroblasts: the dark side of the coin. Am J Cancer Res. 1:482–497. 2011.PubMed/NCBI

42 

Rettig WJ, Garin-Chesa P, Healey JH, et al: Regulation and heteromeric structure of the fibroblast activation protein in normal and transformed cells of mesenchymal and neuroectodermal origin. Cancer Res. 53:3327–3335. 1993.PubMed/NCBI

43 

Crawford Y, Kasman I, Yu L, et al: PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell. 15:21–34. 2009. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Patsouras D, Papaxoinis K, Kostakis A, Safioleas MC, Lazaris AC and Nicolopoulou‑Stamati P: Fibroblast activation protein and its prognostic significance in correlation with vascular endothelial growth factor in pancreatic adenocarcinoma. Mol Med Rep 11: 4585-4590, 2015.
APA
Patsouras, D., Papaxoinis, K., Kostakis, A., Safioleas, M.C., Lazaris, A.C., & Nicolopoulou‑Stamati, P. (2015). Fibroblast activation protein and its prognostic significance in correlation with vascular endothelial growth factor in pancreatic adenocarcinoma. Molecular Medicine Reports, 11, 4585-4590. https://doi.org/10.3892/mmr.2015.3259
MLA
Patsouras, D., Papaxoinis, K., Kostakis, A., Safioleas, M. C., Lazaris, A. C., Nicolopoulou‑Stamati, P."Fibroblast activation protein and its prognostic significance in correlation with vascular endothelial growth factor in pancreatic adenocarcinoma". Molecular Medicine Reports 11.6 (2015): 4585-4590.
Chicago
Patsouras, D., Papaxoinis, K., Kostakis, A., Safioleas, M. C., Lazaris, A. C., Nicolopoulou‑Stamati, P."Fibroblast activation protein and its prognostic significance in correlation with vascular endothelial growth factor in pancreatic adenocarcinoma". Molecular Medicine Reports 11, no. 6 (2015): 4585-4590. https://doi.org/10.3892/mmr.2015.3259
Copy and paste a formatted citation
x
Spandidos Publications style
Patsouras D, Papaxoinis K, Kostakis A, Safioleas MC, Lazaris AC and Nicolopoulou‑Stamati P: Fibroblast activation protein and its prognostic significance in correlation with vascular endothelial growth factor in pancreatic adenocarcinoma. Mol Med Rep 11: 4585-4590, 2015.
APA
Patsouras, D., Papaxoinis, K., Kostakis, A., Safioleas, M.C., Lazaris, A.C., & Nicolopoulou‑Stamati, P. (2015). Fibroblast activation protein and its prognostic significance in correlation with vascular endothelial growth factor in pancreatic adenocarcinoma. Molecular Medicine Reports, 11, 4585-4590. https://doi.org/10.3892/mmr.2015.3259
MLA
Patsouras, D., Papaxoinis, K., Kostakis, A., Safioleas, M. C., Lazaris, A. C., Nicolopoulou‑Stamati, P."Fibroblast activation protein and its prognostic significance in correlation with vascular endothelial growth factor in pancreatic adenocarcinoma". Molecular Medicine Reports 11.6 (2015): 4585-4590.
Chicago
Patsouras, D., Papaxoinis, K., Kostakis, A., Safioleas, M. C., Lazaris, A. C., Nicolopoulou‑Stamati, P."Fibroblast activation protein and its prognostic significance in correlation with vascular endothelial growth factor in pancreatic adenocarcinoma". Molecular Medicine Reports 11, no. 6 (2015): 4585-4590. https://doi.org/10.3892/mmr.2015.3259
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