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Molecular Medicine Reports
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June-2015 Volume 11 Issue 6

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Article

High GOLPH3 expression is associated with poor prognosis and invasion of hepatocellular carcinoma

  • Authors:
    • Qian Li
    • Yuwen Ma
    • Wanpeng Xu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, P.R. China, Department of Anorectal Surgery, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, P.R. China
  • Pages: 4315-4320
    |
    Published online on: January 28, 2015
       https://doi.org/10.3892/mmr.2015.3267
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Abstract

Golgi phosphoprotein 3 (GOLPH3) overexpression has previously been associated with the progression of several solid tumors, which resulted in adverse clinical outcomes. The present study aimed to determine the expression and prognostic significance of GOLPH3 in human hepatocellular carcinoma (HCC). GOLPH3 expression was examined using western blot analysis of 30 paired samples of HCC and adjacent non‑cancerous liver tissues. GOLPH3 expression levels were also assessed using immunohistochemistry in 180 HCC samples and paired controls. In addition, the association of GOLPH3 expression with clinicopathological features and clinical outcome was analyzed. Furthermore, the effect of GOLPH3 on HCC cell proliferation and invasion were determined. Western blot analysis revealed that GOLPH3 expression was significantly elevated in HCC tissue compared with that of the matched adjacent non‑cancerous liver tissue. In addition, the results of the immunohistochemical analysis demonstrated that GOLPH3 expression was positively correlated with the Edmondson‑Steiner grade (P=0.006), vascular invasion (P=0.002) and serum α feto‑protein levels (P=0.015). GOLPH3 expression was found to be an independent factor for predicting the poor overall survival of HCC patients (hazard ratio, 2.01; 95% confidence interval, 1.26‑3.64; P=0.025). In addition, GOLPH3 silencing inhibited the proliferation, invasion and migration of HCC cell lines in vitro. In conclusion, the results of the present study demonstrated that high GOLPH3 levels may be a potential biomarker for the poor prognosis of patients with HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Li Q, Ma Y and Xu W: High GOLPH3 expression is associated with poor prognosis and invasion of hepatocellular carcinoma. Mol Med Rep 11: 4315-4320, 2015.
APA
Li, Q., Ma, Y., & Xu, W. (2015). High GOLPH3 expression is associated with poor prognosis and invasion of hepatocellular carcinoma. Molecular Medicine Reports, 11, 4315-4320. https://doi.org/10.3892/mmr.2015.3267
MLA
Li, Q., Ma, Y., Xu, W."High GOLPH3 expression is associated with poor prognosis and invasion of hepatocellular carcinoma". Molecular Medicine Reports 11.6 (2015): 4315-4320.
Chicago
Li, Q., Ma, Y., Xu, W."High GOLPH3 expression is associated with poor prognosis and invasion of hepatocellular carcinoma". Molecular Medicine Reports 11, no. 6 (2015): 4315-4320. https://doi.org/10.3892/mmr.2015.3267
Copy and paste a formatted citation
x
Spandidos Publications style
Li Q, Ma Y and Xu W: High GOLPH3 expression is associated with poor prognosis and invasion of hepatocellular carcinoma. Mol Med Rep 11: 4315-4320, 2015.
APA
Li, Q., Ma, Y., & Xu, W. (2015). High GOLPH3 expression is associated with poor prognosis and invasion of hepatocellular carcinoma. Molecular Medicine Reports, 11, 4315-4320. https://doi.org/10.3892/mmr.2015.3267
MLA
Li, Q., Ma, Y., Xu, W."High GOLPH3 expression is associated with poor prognosis and invasion of hepatocellular carcinoma". Molecular Medicine Reports 11.6 (2015): 4315-4320.
Chicago
Li, Q., Ma, Y., Xu, W."High GOLPH3 expression is associated with poor prognosis and invasion of hepatocellular carcinoma". Molecular Medicine Reports 11, no. 6 (2015): 4315-4320. https://doi.org/10.3892/mmr.2015.3267
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