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Review

Role of microRNAs in skeletal muscle development and rhabdomyosarcoma (Review)

  • Authors:
    • Huiming Ju
    • Yuefei Yang
    • Anzhi Sheng
    • Xing Jiang
  • View Affiliations / Copyright

    Affiliations: College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China
  • Pages: 4019-4024
    |
    Published online on: January 29, 2015
       https://doi.org/10.3892/mmr.2015.3275
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Abstract

Skeletal muscle accounts for ~40% of total body mass. The principle functions of skeletal muscle include supporting the body structure, controlling motor movements and storing energy. Rhabdomyosarcoma (RMS) is a skeletal muscle‑derived soft tissue tumor widely occurring in the pediatric population. In previous years, microRNAs (miRNAs) have been demonstrated to be important in skeletal muscle development, function and the pathogenesis of various diseases, including RMS. The present review provided an overview of current knowledge on the muscle‑specific and ubiquitously‑expressed miRNAs involved in skeletal muscle differentiation and their dysregulation in RMS. Additionally, the potential use and challenges of miRNAs as therapeutic targets in this soft‑tissue sarcoma were examined and the future prospects for miRNAs in muscle biology and muscle disorders were discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Ju H, Yang Y, Sheng A and Jiang X: Role of microRNAs in skeletal muscle development and rhabdomyosarcoma (Review). Mol Med Rep 11: 4019-4024, 2015.
APA
Ju, H., Yang, Y., Sheng, A., & Jiang, X. (2015). Role of microRNAs in skeletal muscle development and rhabdomyosarcoma (Review). Molecular Medicine Reports, 11, 4019-4024. https://doi.org/10.3892/mmr.2015.3275
MLA
Ju, H., Yang, Y., Sheng, A., Jiang, X."Role of microRNAs in skeletal muscle development and rhabdomyosarcoma (Review)". Molecular Medicine Reports 11.6 (2015): 4019-4024.
Chicago
Ju, H., Yang, Y., Sheng, A., Jiang, X."Role of microRNAs in skeletal muscle development and rhabdomyosarcoma (Review)". Molecular Medicine Reports 11, no. 6 (2015): 4019-4024. https://doi.org/10.3892/mmr.2015.3275
Copy and paste a formatted citation
x
Spandidos Publications style
Ju H, Yang Y, Sheng A and Jiang X: Role of microRNAs in skeletal muscle development and rhabdomyosarcoma (Review). Mol Med Rep 11: 4019-4024, 2015.
APA
Ju, H., Yang, Y., Sheng, A., & Jiang, X. (2015). Role of microRNAs in skeletal muscle development and rhabdomyosarcoma (Review). Molecular Medicine Reports, 11, 4019-4024. https://doi.org/10.3892/mmr.2015.3275
MLA
Ju, H., Yang, Y., Sheng, A., Jiang, X."Role of microRNAs in skeletal muscle development and rhabdomyosarcoma (Review)". Molecular Medicine Reports 11.6 (2015): 4019-4024.
Chicago
Ju, H., Yang, Y., Sheng, A., Jiang, X."Role of microRNAs in skeletal muscle development and rhabdomyosarcoma (Review)". Molecular Medicine Reports 11, no. 6 (2015): 4019-4024. https://doi.org/10.3892/mmr.2015.3275
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