Involvement of Fanconi anemia genes FANCD2 and FANCF in the molecular basis of drug resistance in leukemia

Yao,Chenjiao; Du,Wei; Chen,Haibiug; Xiao,Sheng; Huang,Lihua; Chen,Fang-Ping

doi:10.3892/mmr.2015.3288

June-2015 Volume 11 Issue 6

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June-2015 Volume 11 Issue 6

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Article

Involvement of Fanconi anemia genes FANCD2 and FANCF in the molecular basis of drug resistance in leukemia

Authors:
- Chenjiao Yao
- Wei Du
- Haibiug Chen
- Sheng Xiao
- Lihua Huang
- Fang-Ping Chen
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Affiliations: Department of Hematology, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China, Department of Hematology, Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China
Pages: 4605-4610
|
Published online on: January 30, 2015

https://doi.org/10.3892/mmr.2015.3288
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Abstract

The Fanconi anemia (FA)‑associated proteins FANCF and FANCD2 are important components of the FA pathway of DNA crosslink repair. FANCF and FANCD2 have been found to be involved in drug‑resistant multiple myeloma, ovarian cancer, non‑small‑cell lung cancer, and head and neck cancer. However, it is unclear whether these two genes participate in adriamycin (ADR)‑resistant leukemia. Therefore, the aim of the current study was to investigate FANCF and FANCD2 expression in drug‑resistant and drug‑sensitive leukemia cells. Western blot analysis revealed enhanced FANCF expression and monoubiquitination of FANCD2 in ADR‑resistant cells. Additionally, it was observed that drug‑resistant cells had reduced DNA damage compared with drug‑sensitive cells. The results of this study indicate that the FA pathway may confer leukemia resistance to ADR via enhanced DNA interstrand crosslink repair.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Involvement of Fanconi anemia genes FANCD2 and FANCF in the molecular basis of drug resistance in leukemia

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