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Review

Long non‑coding RNAs: Novel links in respiratory diseases (Review)

  • Authors:
    • Yanru Liu
    • Ruifeng Zhang
    • Kejing Ying
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China
  • Pages: 4025-4031
    |
    Published online on: January 30, 2015
       https://doi.org/10.3892/mmr.2015.3290
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Abstract

Long non‑coding RNAs (lncRNAs) represent a surprisingly novel field in mammalian transcriptome research. With the development of RNA sequencing technology and computational methods, lncRNAs have been demonstrated to have important roles in biological processes at the epigenetic, transcription and post‑transcriptional levels. In addition, the dysregulation of lncRNAs contributes to numerous diseases, including cancer and cardiovascular diseases. The present review discusses the important functions of lncRNAs in respiratory diseases, highlights the mechanistic roles which underlie lncRNAs in lung cancer as well as considers the current and future potential use of lncRNAs as novel biomarkers and therapeutic targets for the treatment of lung cancer.
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1 

Crick FH, Barnett L, Brenner S and Watts-Tobin RJ: General nature of the genetic code for proteins. Nature. 192:1227–1232. 1961. View Article : Google Scholar : PubMed/NCBI

2 

Gutschner T and Diederichs S: The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol. 9:703–719. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Kung JT, Colognori D and Lee JT: Long noncoding RNAs: past, present, and future. Genetics. 193:651–669. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Atkinson SR, Marguerat S and Bähler J: Exploring long non-coding RNAs through sequencing. Semin Cell Dev Biol. 23:200–205. 2012. View Article : Google Scholar

5 

Shi X, Sun M, Liu H, Yao Y and Song Y: Long non-coding RNAs: a new frontier in the study of human diseases. Cancer Lett. 339:159–166. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Yoon JH, Abdelmohsen K and Gorospe M: Posttranscriptional gene regulation by long noncoding RNA. J Mol Biol. 425:3723–3730. 2013. View Article : Google Scholar :

7 

Erdmann VA, Szymansk Mi, Hochberg A, Groot ND and Barciszewski J: Non-coding, mRNA-like RNAs database Y2K. Nucleic Acids Res. 28:197–200. 2000. View Article : Google Scholar

8 

Mituyama T, Yamada K, Hattori E, et al: The Functional RNA Database 3.0: databases to support mining and annotation of functional RNAs. Nucleic Acids Res. 37:D89–D92. 2009. View Article : Google Scholar :

9 

Dinger ME, Pang KC, Mercer TR, Crowe ML, Grimmond SM and Mattick JS: NRED: a database of long noncoding RNA expression. Nucleic Acids Res. 37:D122–D126. 2009. View Article : Google Scholar :

10 

Amaral PP, Clark MB, Gascoigne DK, Dinger ME and Mattick JS: LncRNAdb: a reference database for long noncoding RNAs. Nucleic Acids Res. 39:D146–D151. 2011. View Article : Google Scholar :

11 

Liao Q, Xiao H, Bu DC, et al: ncFANs: a web server for functional annotation of long non-coding RNAs. Nucleic Acids Res. 39:W118–W124. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Bu DC, Yu KT, Sun SL, et al: NONCODE v3.0: integrative annotation of long noncoding RNAs. Nucleic Acids Res. 40:D210–D215. 2012. View Article : Google Scholar :

13 

Yang JH, Li JH, Jiang S, Zhou H and Qu LH: ChIPBase: a database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data. Nucleic acids Res. 41:D177–D187. 2013. View Article : Google Scholar :

14 

Volders PJ, Helsens K, Wang X, et al: LNCipedia: a database for annotated human lncRNA transcript sequences and structures. Nucleic acids Res. 41:D246–D251. 2013. View Article : Google Scholar :

15 

Paraskevopoulou MD, Georgakilas G, Kostoulas N, Reczko M, Maragkakis M, Dalamagas TM and Hatzigeorgiou AG: DIANA-LncBase: experimentally verified and computationally predicted microRNA targets on long non-coding RNAs. Nucleic Acids Res. 41:D239–D245. 2013. View Article : Google Scholar :

16 

Chen G, Wang ZY, Wang DQ, et al: LncRNADisease: a database for long-non-coding RNA-associated diseases. Nucleic Acids Res. 41:D983–D986. 2013. View Article : Google Scholar :

17 

Bhartiya D, Pal K, Ghosh S, et al: lncRNome: a comprehensive knowledgebase of human long noncoding RNAs. Database (Oxford). 2013. pp. bat0342013, View Article : Google Scholar

18 

Piao H and Ma L: Non-coding RNAs as regulators of mammary development and breast cancer. J Mammary Gland Biol Neoplasia. 17:33–42. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Geng YJ, Xie SL, Li Q, Ma J and Wang GY: Large intervening non-coding RNA HOTAIR is associated with hepatocellular carcinoma progression. J Int Med Res. 39:2119–2128. 2011. View Article : Google Scholar

20 

Kogo R, Shimamura T, Mimori K, et al: Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res. 71:6320–6326. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Nilsson J, Skog J, Nordstrand A, Baranov V, Mincheva- Nilsson L, Breakefield XO and Widmark A: Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer. Br J Cancer. 100:1603–1607. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Ng D, Toure O, Wei MH, et al: Identification of a novel chromosome region, 13q21.33-q22.2, for susceptibility genes in familial chronic lymphocytic leukemia. Blood. 109:916–925. 2007. View Article : Google Scholar

23 

Huarte M and Rinn JL: Large non-coding RNAs: missing links in cancer? Hum Mol Genet. 19(R2): R152–R161. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Holdt LM and Teupser D: Recent studies of the human chromosome 9p21 locus, which is associated with atherosclerosis in human populations. Arterioscler Thromb Vasc Biol. 32:196–206. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Liu Y, Sanoff HK, Cho H, et al: INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis. PLoS One. 4:e50272009. View Article : Google Scholar : PubMed/NCBI

26 

Ishii N, Ozaki K, Sato H, et al: Identification of a novel non-coding RNA, MIAT that confers risk of myocardial infarction. J Hum Genet. 51:1087–1099. 2006. View Article : Google Scholar

27 

Johnson R: Long non-coding RNAs in Huntington’s disease neurodegeneration. Neurobiol Dis. 46:245–254. 2012. View Article : Google Scholar

28 

Qureshi IA, Mattick JS and Mehler MF: Long non-coding RNAs in nervous system function and disease. Brain Res. 1338:20–35. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Decourt B and Sabbagh MN: BACE1 as a potential biomarker for Alzheimer’s disease. J Alzheimers Dis. 24(Suppl 2): 53–59. 2011.

30 

Wang XS, Zhang Z, Wang HC, et al: Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma. Clin Cancer Res. 12:4851–4858. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Zoetis T and Hurtt ME: Species comparison of lung development. Birth Defects Res B Dev Reprod Toxicol. 68:121–124. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Lü J, Qian J, Chen F, Tang X, Li C and Cardoso WV: Differential expression of components of the microRNA machinery during mouse organogenesis. Biochem Biophys Res Commun. 334:319–323. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Bhaskaran M, Wang Y, Zhang H, et al: MicroRNA-127 modulates fetal lung development. Physiol Genomics. 37:268–278. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Bishop NB, Stankiewicz P and Steinhorn RH: Alveolar capillary dysplasia. Am J Respir Crit Care Med. 184:172–179. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Stankiewicz P, Sen P, Bhatt SS, et al: Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations. Am J Hum Genet. 84:780–791. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Mahlapuu M, Enerbäck S and Carlsson P: Haploinsufficiency of the Forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations. Development. 128:2397–2406. 2001.PubMed/NCBI

37 

Szafranski P, Dharmadhikari AV, Brosens E, et al: Small noncoding differentially methylated copy-number variants, including lncRNA genes, cause a lethal lung developmental disorder. Genome Res. 23:23–33. 2013. View Article : Google Scholar :

38 

Getz GS: Bridging the innate and adaptive immune systems. J Lipid Res. 46:619–622. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Carpenter S, Aiello D, Atianand MK, et al: A long noncoding RNA mediates both activation and repression of immune response genes. Science. 341:789–792. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Rapicavoli NA, Qu K, Zhang JJ, Mikhail M, Laberge RM and Chang HY: A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics. ELife. 2:e007622013. View Article : Google Scholar : PubMed/NCBI

41 

Peng X, Gralinski L, Armour CD, et al: Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling. mBio. 1:e00206–e00210. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Vigneau S, Rohrlich PS, Rahic MB and Bureau JF: Tmevpg1, a candidate gene for the control of Theiler’s virus persistence, could be implicated in the regulation of interferon. J Virol. 77:5632–5638. 2003. View Article : Google Scholar : PubMed/NCBI

43 

Collier SP, Collins PL, Williams CL, Boothby MR and Aune TM: Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells. J Immunol. 189:2084–2088. 2012. View Article : Google Scholar : PubMed/NCBI

44 

GomeZ JA, Wapinski OL, Yang YW, et al: The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-γ locus. Cell. 152:743–754. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Pang KC, Dinger ME, Mercer TR, Malquori L, Grimmond SM, Chen W and Mattick JS: Genome-wide identification of long noncoding RNAs in CD8+ T cells. J Immunol. 182:7738–7748. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Hu G, Tang Q, Sharma S, et al: Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation. Nat Immunol. 14:1190–1198. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Janeway CA Jr, Travers P, Walport M and Shlomchik M: Principles of innate and adaptive immunity. Immunobiology: The Immune System in Health and Disease. 5th. Garland Science; New York, NY: 2001

48 

Kawai T and Akira S: The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nature Immunol. 11:373–384. 2010. View Article : Google Scholar

49 

Kawai T and Akira S: Toll-like receptor and RIG-1-like receptor signaling. Ann NY Acad Sci. 1143:1–20. 2008. View Article : Google Scholar

50 

Medzhitov R and Horng T: Transcriptional control of the inflammatory response. Nat Rev Immunol. 9:692–703. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Liu SY, Sanchez DJ and Cheng G: New developments in the induction and antiviral effectors of type I interferon. Curr Opin Immunol. 23:57–64. 2011. View Article : Google Scholar

52 

Hogan RJ, Gao G, Rowe T, et al: Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1. J Virol. 78:11416–11421. 2004. View Article : Google Scholar : PubMed/NCBI

53 

Rupani H, Sanchez-Elsner T and Howarth P: MicroRNAs and respiratory diseases. Eur Respir J. 41:695–705. 2013. View Article : Google Scholar

54 

Thai P, Statt S, Chen CH, Liang E, Campbell C and Wu R: Characterization of a novel long noncoding RNA, SCAL1, induced by cigarette smoke and elevated in lung cancer cell lines. Am J Respir Cell Mol Biol. 49:204–211. 2013. View Article : Google Scholar : PubMed/NCBI

55 

Kaspar JW, Niture SK and Jaiswal AK: Nrf2:INrf2 (Keap1) signaling in oxidative stress. Free Radical Biol Med. 47:1304–1309. 2009. View Article : Google Scholar

56 

Lustig O, Ariel I, Ilan J, Lev-Lehman E, De-Groot N and Hochberg A: Expression of the imprinted gene H19 in the human fetus. Mol Reprod Dev. 38:239–246. 1994. View Article : Google Scholar : PubMed/NCBI

57 

Gabory A, Jammes H and Dandolo L: The H19 locus: role of an imprinted non-coding RNA in growth and development. Bioessays. 32:473–480. 2010. View Article : Google Scholar : PubMed/NCBI

58 

Matouk IJ, DeGroot N, Mezan S, Ayesh S, Abu-lail R, Hochberg A and Galun E: The H19 non-coding RNA is essential for human tumor growth. PloS One. 2:e8452007. View Article : Google Scholar : PubMed/NCBI

59 

Kaplan R, Luettich K, Heguy A, Hackett NR, Harvey BG and Crystal RG: Monoallelic up-regulation of the imprinted H19 gene in airway epithelium of phenotypically normal cigarette smokers. Cancer Res. 63:1475–1482. 2003.PubMed/NCBI

60 

Kondo M, Suzuki H, Ueda R, Osada H, Takagi K and Takahashi T: Frequent loss of imprinting of the H19 gene is often associated with its overexpression in human lung cancers. Oncogene. 10:1193–1198. 1955.

61 

Kondo M and Takahashi T: Altered genomic imprinting in the IGF2 and H19 genes in human lung cancer. Nihon Rinsho. 54:492–496. 1996.In Japanese. PubMed/NCBI

62 

Xu G, Chen J and Pan Q: Long noncoding RNA expression profiles of lung adenocarcinoma ascertained by microarray analysis. PLoS One. 9:e1040442014. View Article : Google Scholar : PubMed/NCBI

63 

White NM, Cabanski CR, Silva-Fisher JM, Dang HX, Govindan R and Maher CA: Transcriptome sequencing reveals altered long intergenic non-coding RNAs in lung cancer. Genome Biol. 13:4292014. View Article : Google Scholar

64 

Jelinic P and Shaw P: Loss of imprinting and cancer. J Pathol. 221:261–268. 2007. View Article : Google Scholar

65 

Barsyte-Lovejoy D, Lau SK, Boutros PC, et al: The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis. Cancer Res. 66:5330–5337. 2006. View Article : Google Scholar : PubMed/NCBI

66 

Cai X and Cullen BR: The imprinted H19 noncoding RNA is a primary microRNA precursor. Rna. 13:313–316. 2007. View Article : Google Scholar : PubMed/NCBI

67 

Tsang WP, Ng EK, Ng SS, Jin H, Yu J, Sung JJ and Kwok TT: Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer. Carcinogenesis. 31:350–358. 2010. View Article : Google Scholar

68 

Tim W and Feinberg AP: Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host. Nat Rev Cancer. 13:497–510. 2013. View Article : Google Scholar

69 

Lu KH, Li W, Liu XH, et al: Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression. BMC Cancer. 13:4612013. View Article : Google Scholar : PubMed/NCBI

70 

Gupta RA, Shah N, Wang KC, et al: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 464:1071–1076. 2010. View Article : Google Scholar : PubMed/NCBI

71 

Yang Z, Zhou L, Wu LM, Lai MC, Xie HY, Zhang F and Zheng SS: Overexpression of long noncoding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol. 18:1243–1250. 2011. View Article : Google Scholar : PubMed/NCBI

72 

Kogo Shimamura T, Mimori K, et al: Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res. 71:6320–6326. 2011. View Article : Google Scholar

73 

Egeblad M, Rasch MG and Weaver VM: Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol. 22:697–706. 2010. View Article : Google Scholar : PubMed/NCBI

74 

Zhuang Y, Wang X, Nguyen H, et al: Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type I collagen. J Hematol Oncol. 6:352013. View Article : Google Scholar : PubMed/NCBI

75 

Ji P, Diederichs S, Wang W, et al: MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene. 22:8031–8041. 2003. View Article : Google Scholar : PubMed/NCBI

76 

Tano K, Mizuno R, Okada T, et al: MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes. FEBS Lett. 584:4575–4580. 2010. View Article : Google Scholar : PubMed/NCBI

77 

Nakagawa T, Endo H, YoKoyama M, et al: Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer. Biochem Biophys Res Commun. 436:319–324. 2013. View Article : Google Scholar : PubMed/NCBI

78 

Tsai MC, Manor O, Wan Y, et al: Chang, Long noncoding RNA as modular scaffold of histone modification complexes. Science. 329:689–693. 2010. View Article : Google Scholar : PubMed/NCBI

79 

Schmidt LH, Spieker T, Koschmieder S, et al: The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth. J Thorac Oncol. 6:1984–1992. 2011. View Article : Google Scholar : PubMed/NCBI

80 

Gutschner T, Hämmerle M, Eissmann M, et al: The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res. 73:1180–1189. 2013. View Article : Google Scholar :

81 

Lee Y, Lee M and Kim S: Gas 6 induces cancer cell migration and epithelial-mesenchymal transition through upregulation of MAPK and Slug. Biochem Biophys Res Commun. 434:8–14. 2013. View Article : Google Scholar : PubMed/NCBI

82 

Han L, Kong R, Yin DD, Zhang EB, Xu TP, De W and Shu YQ: Low expression of long noncoding RNA GAS6-AS1 predicts a poor prognosis in patients with NSCLC. Med Oncol. 30:6942013. View Article : Google Scholar : PubMed/NCBI

83 

Brody H: Lung cancer. Nature. 513:S12014. View Article : Google Scholar : PubMed/NCBI

84 

Takahashi K, Yan IK, Kogure T, Haga H and Patel T: Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer. FEBS Open Bio. 4:458–467. 2014. View Article : Google Scholar : PubMed/NCBI

85 

Fan Y, Shen B, Tan M, Mu X, Qin Y, Zhang F and Liu Y: Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling. FEBS J. 281:1750–1758. 2014. View Article : Google Scholar : PubMed/NCBI

86 

Liu Z, Sun M, Lu K, et al: The long noncoding RNA HOTAIR contributes to cisplatin resistance of human lung adenocarcinoma cells via downregualtion of p21 (WAF1/CIP1) expression. PloS one. 8:e772932013. View Article : Google Scholar

87 

Sing A, Boldin-Adamasky S, Thimmulappa RK, et al: RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. Cancer Res. 68:7975–7984. 2008. View Article : Google Scholar

88 

Oh S, Kim Y, Kim J, Kwon D and Lee E: Elevated pressure, a novel cancer therapeutic tool for sensitizing cisplatin-mediated apoptosis in A549. Biochem Biophys Res Commun. 399:91–97. 2010. View Article : Google Scholar : PubMed/NCBI

89 

Voelkel NF, Gomez-Arroyo J, Abbate A, Bogaard HJ and Nicolls MR: Pathobiology of pulmonary arterial hypertension and right ventricular failure. Eur Respir J. 40:1555–1565. 2012. View Article : Google Scholar : PubMed/NCBI

90 

Guignabert C and Dorfmuller P: Pathology and pathobiology of pulmonary hypertension. Semin Respir Crit Care Med. 34:551–559. 2013. View Article : Google Scholar : PubMed/NCBI

91 

Caruso P, MacLean MR and Khanin R: Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. Arteriosclerosis Thromb Vasc Biol. 30:716–723. 2010. View Article : Google Scholar

92 

Lüscher TF: Endothelial dysfunction: the role and impact of the renin-angiotensin system. Heart. 84(Suppl 1): i20–i22. 2000. View Article : Google Scholar : PubMed/NCBI

93 

Shenoy V, Qi Y, Katovich MJ and Raizada MK: ACE2, a promising therapeutic target for pulmonary hypertension. Curr Opin Pharmacol. 11:150–155. 2011. View Article : Google Scholar : PubMed/NCBI

94 

Leung A, Trac C, Jin W, et al: Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells. Circ Res. 113:266–278. 2013. View Article : Google Scholar : PubMed/NCBI

95 

Zhu N, Zhang D, Chen S, et al: Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration. Atherosclerosis. 215:286–293. 2011. View Article : Google Scholar : PubMed/NCBI

96 

Liu X, Cheng Y, Zhang S, Lin Y, Yang J and Zhang C: A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia. Circ Res. 104:476–487. 2009. View Article : Google Scholar : PubMed/NCBI

97 

Noble PW and Homer RJ: Back to the future: historical perspective on the pathogenesis of idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 33:113–120. 2005. View Article : Google Scholar : PubMed/NCBI

98 

Cao G, Zhang J, Wang M, Song X, Liu W, Mao C and Lv C: Differential expression of long non-coding RNAs in bleomycin-induced lung fibrosis. Int J Mol Med. 32:355–364. 2013.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Zhang R and Ying K: Long non‑coding RNAs: Novel links in respiratory diseases (Review). Mol Med Rep 11: 4025-4031, 2015.
APA
Liu, Y., Zhang, R., & Ying, K. (2015). Long non‑coding RNAs: Novel links in respiratory diseases (Review). Molecular Medicine Reports, 11, 4025-4031. https://doi.org/10.3892/mmr.2015.3290
MLA
Liu, Y., Zhang, R., Ying, K."Long non‑coding RNAs: Novel links in respiratory diseases (Review)". Molecular Medicine Reports 11.6 (2015): 4025-4031.
Chicago
Liu, Y., Zhang, R., Ying, K."Long non‑coding RNAs: Novel links in respiratory diseases (Review)". Molecular Medicine Reports 11, no. 6 (2015): 4025-4031. https://doi.org/10.3892/mmr.2015.3290
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Zhang R and Ying K: Long non‑coding RNAs: Novel links in respiratory diseases (Review). Mol Med Rep 11: 4025-4031, 2015.
APA
Liu, Y., Zhang, R., & Ying, K. (2015). Long non‑coding RNAs: Novel links in respiratory diseases (Review). Molecular Medicine Reports, 11, 4025-4031. https://doi.org/10.3892/mmr.2015.3290
MLA
Liu, Y., Zhang, R., Ying, K."Long non‑coding RNAs: Novel links in respiratory diseases (Review)". Molecular Medicine Reports 11.6 (2015): 4025-4031.
Chicago
Liu, Y., Zhang, R., Ying, K."Long non‑coding RNAs: Novel links in respiratory diseases (Review)". Molecular Medicine Reports 11, no. 6 (2015): 4025-4031. https://doi.org/10.3892/mmr.2015.3290
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