MicroRNA-204 targets signal transducer and activator of transcription 5 expression and inhibits proliferation of B-cell lymphoma cells

  • Authors:
    • Li Wu
    • Yong Li
    • Jian‑Min Fan
    • Zhi‑Min Zhang
    • Jin‑Ling Ouyang
    • Ting‑Ting Ni
    • Hai‑Xia Wu
    • Hang Li
  • View Affiliations

  • Published online on: February 4, 2015     https://doi.org/10.3892/mmr.2015.3298
  • Pages: 4567-4572
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Abstract

The function of microRNAs (miRNAs) in tumorigenesis has been extensively investigated. In the present study, the aim was to investigate the expression and role of miR‑204 in B‑cell lymphoma. The present study demonstrated that miR‑204 is downregulated in B‑cell lymphoma. Using in vitro studies, overexpression of miR‑204 was shown to inhibit growth in Daudi and Raji B‑cell lymphoma cell lines. Furthermore, miR‑204 could bind the 3'‑untranslated region of signal transducer activator of transcription 5 (STAT5), a transcription factor that promotes B‑cell lymphoma oncogenesis. Re‑introduction of STAT5 reversed the antiproliferative roles of miR‑204, confirming the specific importance of STAT5 for miR‑204 action in cell proliferation. The present study suggests a novel mechanism for dysregulated miRNAs in the progression of B‑cell lymphoma.
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June-2015
Volume 11 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wu L, Li Y, Fan JM, Zhang ZM, Ouyang JL, Ni TT, Wu HX and Li H: MicroRNA-204 targets signal transducer and activator of transcription 5 expression and inhibits proliferation of B-cell lymphoma cells. Mol Med Rep 11: 4567-4572, 2015
APA
Wu, L., Li, Y., Fan, J., Zhang, Z., Ouyang, J., Ni, T. ... Li, H. (2015). MicroRNA-204 targets signal transducer and activator of transcription 5 expression and inhibits proliferation of B-cell lymphoma cells. Molecular Medicine Reports, 11, 4567-4572. https://doi.org/10.3892/mmr.2015.3298
MLA
Wu, L., Li, Y., Fan, J., Zhang, Z., Ouyang, J., Ni, T., Wu, H., Li, H."MicroRNA-204 targets signal transducer and activator of transcription 5 expression and inhibits proliferation of B-cell lymphoma cells". Molecular Medicine Reports 11.6 (2015): 4567-4572.
Chicago
Wu, L., Li, Y., Fan, J., Zhang, Z., Ouyang, J., Ni, T., Wu, H., Li, H."MicroRNA-204 targets signal transducer and activator of transcription 5 expression and inhibits proliferation of B-cell lymphoma cells". Molecular Medicine Reports 11, no. 6 (2015): 4567-4572. https://doi.org/10.3892/mmr.2015.3298