MicroRNA-204 targets signal transducer and activator of transcription 5 expression and inhibits proliferation of B-cell lymphoma cells

Wu,Li; Li,Yong; Fan,Jian‑Min; Zhang,Zhi‑Min; Ouyang,Jin‑Ling; Ni,Ting‑Ting; Wu,Hai‑Xia; Li,Hang

doi:10.3892/mmr.2015.3298

June-2015 Volume 11 Issue 6

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June-2015 Volume 11 Issue 6

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Article

MicroRNA-204 targets signal transducer and activator of transcription 5 expression and inhibits proliferation of B-cell lymphoma cells

Authors:
- Li Wu
- Yong Li
- Jian‑Min Fan
- Zhi‑Min Zhang
- Jin‑Ling Ouyang
- Ting‑Ting Ni
- Hai‑Xia Wu
- Hang Li
View Affiliations / Copyright

Affiliations: Department of Oncology, People's Hospital of Guizhou Province, Guiyang, Guizhou 550002, P.R. China, Department of Hematology, Guiyang College of Medicine, Guiyang, Guizhou 550004, P.R. China
Pages: 4567-4572
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Published online on: February 4, 2015

https://doi.org/10.3892/mmr.2015.3298
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Abstract

The function of microRNAs (miRNAs) in tumorigenesis has been extensively investigated. In the present study, the aim was to investigate the expression and role of miR‑204 in B‑cell lymphoma. The present study demonstrated that miR‑204 is downregulated in B‑cell lymphoma. Using in vitro studies, overexpression of miR‑204 was shown to inhibit growth in Daudi and Raji B‑cell lymphoma cell lines. Furthermore, miR‑204 could bind the 3'‑untranslated region of signal transducer activator of transcription 5 (STAT5), a transcription factor that promotes B‑cell lymphoma oncogenesis. Re‑introduction of STAT5 reversed the antiproliferative roles of miR‑204, confirming the specific importance of STAT5 for miR‑204 action in cell proliferation. The present study suggests a novel mechanism for dysregulated miRNAs in the progression of B‑cell lymphoma.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

MicroRNA-204 targets signal transducer and activator of transcription 5 expression and inhibits proliferation of B-cell lymphoma cells

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