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Article

Stromal cell-derived factor-1 G801A polymorphism and the risk factors for cervical cancer

  • Authors:
    • Andrzej Roszak
    • Matthew Misztal
    • Anna Sowińska
    • Paweł P. Jagodziński
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy and Gynecological Oncology, Greater Poland Cancer Center, Poznań 61‑866, Poland , Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, Poznań 60‑781, Poland, Department of Computer Science and Statistics, Poznań University of Medical Sciences, Poznań 60‑781, Poland
  • Pages: 4633-4638
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    Published online on: February 6, 2015
       https://doi.org/10.3892/mmr.2015.3315
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Abstract

Although certain studies have demonstrated no association between the stromal cell‑derived factor‑1 (SDF1‑3') G801A single nucleotide polymorphism (SNP) and cervical carcinoma, the interactions between the SDF1‑3' G801A SNP and contraceptive use, menopausal status, parity and tobacco smoking remain to be fully elucidated. Using polymerase chain reaction‑restriction fragment length polymorphism, the distribution of SDF1‑3' G801A genotypes in patients with cervical cancer (n=462) against control groups (n=497) was investigated. Logistic regression analysis, adjusting for age, pregnancy, oral contraceptive use, tobacco smoking and menopausal status, did not identify the SDF1‑3' G801A polymorphism as a genetic risk factor for cervical cancer. The adjusted odds ratio (OR) for patients with the A/G, vs. G/G genotype was 1.203, with a 95% confidence interval (CI) of 0.909‑1.591 (P=0.196). The adjusted OR for the A/A, vs. G/G genotype was 1.296 (95% CI=0.930‑1.807; P=0.125) and for the A/A or A/G, vs. G/G genotype was 1.262 (95% CI=0.964‑1.653; P=0.090)]. The P‑value of the χ2 test of the trend observed for the SDF1‑3' G801A polymorphism was at the borderline of being statistically significant (ptrend=0.0484). Stratified analyses between the distribution of the SDF1‑3' G801A genotypes and cervical cancer risks demonstrated that this polymorphism may be a risk factor for patients with a positive history of tobacco smoking (1.778; 95% CI=1.078‑2.934; P=0.0235). These findings suggested that the SDF1‑3' G801A polymorphism may be a genetic risk factor for cervical cancer in patients with a positive history of tobacco smoking.
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Copy and paste a formatted citation
Spandidos Publications style
Roszak A, Misztal M, Sowińska A and Jagodziński PP: Stromal cell-derived factor-1 G801A polymorphism and the risk factors for cervical cancer. Mol Med Rep 11: 4633-4638, 2015.
APA
Roszak, A., Misztal, M., Sowińska, A., & Jagodziński, P.P. (2015). Stromal cell-derived factor-1 G801A polymorphism and the risk factors for cervical cancer. Molecular Medicine Reports, 11, 4633-4638. https://doi.org/10.3892/mmr.2015.3315
MLA
Roszak, A., Misztal, M., Sowińska, A., Jagodziński, P. P."Stromal cell-derived factor-1 G801A polymorphism and the risk factors for cervical cancer". Molecular Medicine Reports 11.6 (2015): 4633-4638.
Chicago
Roszak, A., Misztal, M., Sowińska, A., Jagodziński, P. P."Stromal cell-derived factor-1 G801A polymorphism and the risk factors for cervical cancer". Molecular Medicine Reports 11, no. 6 (2015): 4633-4638. https://doi.org/10.3892/mmr.2015.3315
Copy and paste a formatted citation
x
Spandidos Publications style
Roszak A, Misztal M, Sowińska A and Jagodziński PP: Stromal cell-derived factor-1 G801A polymorphism and the risk factors for cervical cancer. Mol Med Rep 11: 4633-4638, 2015.
APA
Roszak, A., Misztal, M., Sowińska, A., & Jagodziński, P.P. (2015). Stromal cell-derived factor-1 G801A polymorphism and the risk factors for cervical cancer. Molecular Medicine Reports, 11, 4633-4638. https://doi.org/10.3892/mmr.2015.3315
MLA
Roszak, A., Misztal, M., Sowińska, A., Jagodziński, P. P."Stromal cell-derived factor-1 G801A polymorphism and the risk factors for cervical cancer". Molecular Medicine Reports 11.6 (2015): 4633-4638.
Chicago
Roszak, A., Misztal, M., Sowińska, A., Jagodziński, P. P."Stromal cell-derived factor-1 G801A polymorphism and the risk factors for cervical cancer". Molecular Medicine Reports 11, no. 6 (2015): 4633-4638. https://doi.org/10.3892/mmr.2015.3315
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