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Article

Ovarian cancer stem-like cells elicit the polarization of M2 macrophages

  • Authors:
    • Qing Zhang
    • Da‑Jun Cai
    • Bin Li
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450014, P.R. China, Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
  • Pages: 4685-4693
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    Published online on: February 9, 2015
       https://doi.org/10.3892/mmr.2015.3323
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Abstract

Ovarian cancer is a life‑threatening disease in females worldwide. The polarization of macrophages is crucial in oncogenesis and the development of ovarian cancer. Increasing evidence has supported the correlation between ovarian cancer stem‑like cells (OCSCs) and macrophages, however, whether OCSCs can affect the polarization of macrophages and the underlying mechanisms involved remain to be elucidated. To examine the interplay between OCSCs and macrophages, a co‑culture system was used to detect the effect of OCSCs on macrophage polarization. The expression of cluster of differentiation 206+ and the secretion of interleukin‑10 were significantly increased and the production of tumor necrosis factor‑α was suppressed, confirming macrophage polarization to M2 macrophages. Further investigation of the macrophages in a Transwell culture system with OCSCs revealed polarization to the M2 macrophages to a similar extent, indicating that the cytokines of the OCSCs, rather than direct cell‑cell contact, are important for the polarization of M2 macrophages. Furthermore, the expression levels of chemokine (C‑C motif) ligand (CCL)2, cyclooxygenase (COX)‑2 and prostaglandin E2 (PGE2) were increased in the Transwell system and the inhibition of COX‑2, but not CCL2, significantly decreased the polarization of the M2 macrophages. In addition, mechanistic analysis revealed the importance of the COX‑2/PGE2 pathway in OCSCs to activate Janus kinase (JAK) signaling in macrophages to elicit M2 polarization. These findings provided the first evidence, to the best of our knowledge, that OCSCs are capable of altering macrophages into the M2 phenotype via the overexpression of COX‑2 and the increased production of PGE2 cytokines and that the JAK signaling pathway in macrophages is important for this alteration. The present study provided evidence supporting possible molecular targets for cancer treatment.
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1 

Hamilton W, Peters TJ, Bankhead C and Sharp D: Risk of ovarian cancer in women with symptoms in primary care: Population based case-control study. BMJ. 339:2998–3005. 2009. View Article : Google Scholar

2 

Torri V, Harper PG, Colombo N, Sandercock J and Parmar MK: Paclitaxel and cisplatin in ovarian cancer. J Clin Oncol. 19:2349–2351. 2000.

3 

Dean M: ABC transporters, drug resistance, and cancer stem cells. J Mammary Gland Biol Neoplasia. 14:3–9. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Clarke MF and Fuller M: Stem cells and cancer: two faces of eve. Cell. 124:1111–1115. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Alvero AB, Chen R and Fu HH: Molecular phenotyping of human ovarian cancer stem cells unravel the mechanisms for repair and chemo-resistance. Cell Cycle. 8:158–166. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Dean M, Fojo T and Bates S: Tumour stem cells and drug resistance. Nat Rev Cancer. 5:275–284. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Johnstone RW, Ruefli AA and Lowe SW: Apoptosis: a link between cancer genetics and chemotherapy. Cell. 108:153–164. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Eyler CE and Rich JN: Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol. 26:2839–2845. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Hanahan D and Coussens LM: Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. 21:309–322. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Condeelis J and Pollard JW: Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell. 124:263–266. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Vermeulen L, Felipe De Sousa EM, van der Heijden M, et al: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol. 12:468–476. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Wu A, Wei J, Kong L-Y, et al: Glioma cancer stem cells induce immunosuppressive macrophages/microglia. Neuro Oncol. 12:1113–1125. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Sica A and Mantovani A: Macrophage plasticity and polarization: in vivo veritas. J Clin Invest. 122:787–795. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Murray PJ and Wynn TA: Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol. 11:723–737. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Friedl P and Wolf K: Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer. 3:362–374. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Coffelt SB, Hughes R and Lewis CE: Tumor-associated macrophages: effectors of angiogenesis and tumor progression. Biochim Biophys Acta. 1796:11–18. 2009.PubMed/NCBI

17 

Beyer M and Schultze JL: Regulatory T cells in cancer. 108:pp. 804–811. 2006

18 

Siveen KS and Kuttan G: Role of macrophages in tumour progression. Immunol Lett. 123:97–102. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Lewis CE and Pollard JW: Distinct role of macrophages in different tumor microenvironments. Cancer Res. 66:605–612. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Hu L, McArthur C and Jaffe R: Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant. Br J Cancer. 102:1276–1283. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Spira AI, Marx PA, Patterson BK, Mahoney J, Koup RA, Wolinsky SM and Ho DD: Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques. J Exp Med. 183:215–225. 1996. View Article : Google Scholar : PubMed/NCBI

22 

Tacke RS, Tosello-Trampont A, Nguyen V, Mullins DW and Hahn YS: Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway. J Biol Chem. 286:10847–10855. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Barboni B, Curini V, Russo V, et al: Indirect co-culture with tendons or tenocytes can program amniotic epithelial cells towards stepwise tenogenic differentiation. PLoS One. 7:e309742012. View Article : Google Scholar : PubMed/NCBI

24 

Ohtaki H, Ylostalo JH, Foraker JE, et al: Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses. Proc Natl Acad Sci USA. 105:14638–14643. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative CT method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar

26 

Subbaramaiah K, Morris PG, Zhou XK, et al: Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women. Cancer Discov. 2:356–365. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Parazzoli S, Harmon J, Vallerie SN, Zhang T, Zhou H and Robertson RP: COX-2, not mPGES-1, is the dominant regulator of IL-1β-induced PGE2 production and subsequent inhibition of pancreatic islet β-cell function during inflammation. J Biol Chem. 2:486–495. 2012.

28 

Allavena P, Sica A, Solinas G, Porta C and Mantovani A: The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages. Crit Rev Oncol Hematol. 66:1–9. 2008. View Article : Google Scholar

29 

Kim J and Hematti P: Mesenchymal stem cell-educated macrophages: A novel type of alternatively activated macrophages. Exp Hematol. 37:1445–1453. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Zhang QZ, Su WR, Shi SH, et al: Human gingiva-derived mesenchymal stem cells elicit polarization of M2 macrophages and enhance cutaneous wound healing. Stem Cells. 28:1856–1868. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Bouhlel M, Derudas B, Rigamonti E, et al: PPARγ activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties. Cell Metab. 6:137–143. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Monti P, Leone BE, Marchesi F, et al: The CC chemokine MCP-1/CCL2 in pancreatic cancer progression regulation of expression and potential mechanisms of antimalignant activity. Cancer Res. 63:7451–7461. 2003.PubMed/NCBI

33 

Singh B, Berry JA, Shoher A, Ramakrishnan V and Lucci A: COX-2 overexpression increases motility and invasion of breast cancer cells. Int J Oncol. 26:1393–1399. 2005.PubMed/NCBI

34 

Brown JR and DuBois RN: COX-2: a molecular target for colorectal cancer prevention. J Clin Oncol. 23:2840–2855. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Ferrandina G, Lauriola L, Zannoni G, et al: Increased cyclooxy-genase-2 (COX-2) expression is associated with chemotherapy resistance and outcome in ovarian cancer patients. Ann Oncol. 13:1205–1211. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Roca H, Varsos ZS, Sud S, Craig MJ, Ying C and Pienta KJ: CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization. J Biol Chem. 284:34342–34354. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Martinez FO, Gordon S, Locati M and Mantovani A: Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: New molecules and patterns of gene expression. J Immunol. 177:7303–7311. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Ding Y-B, Shi R-H, Tong J-D, et al: PGE2 up-regulates vascular endothelial growth factor expression in MKN28 gastric cancer cells via epidermal growth factor receptor signaling system. Exp Oncol. 27:108–113. 2005.PubMed/NCBI

39 

Dorsam RT and Gutkind JS: G-protein-coupled receptors and cancer. Nat Rev Cancer. 7:79–94. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Sica A, Schioppa T, Mantovani A and Allavena P: Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer. 42:717–727. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Aron-Wisnewsky J, Tordjman J, Poitou C, et al: Human adipose tissue macrophages: m1 and m2 cell surface markers in subcutaneous and omental depots and after weight loss. J Clin Endocrinol Metab. 94:4619–4623. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Hagemann T, Wilson J, Burke F, et al: Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype. J Immunol. 176:5023–5032. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Zhu W, Huang L, Li Y, et al: Mesenchymal stem cell-secreted soluble signaling molecules potentiate tumor growth. Cell Cycle. 10:3198–3207. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Saraiva M and O’Garra A: The regulation of IL-10 production by immune cells. Nature Reviews Immunol. 10:170–181. 2010. View Article : Google Scholar

45 

Sinha P, Clements VK, Bunt SK, Albelda SM and Ostrand-Rosenberg S: Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response. J Immunol. 179:977–983. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Wojnarowicz P, Gambaro K, de Ladurantaye M, et al: Overexpressing the CCL2 chemokine in an epithelial ovarian cancer cell line results in latency of in vivo tumourigenicity. Oncogenesis. 1:27–36. 2012. View Article : Google Scholar

47 

Zhang J, Patel L and Pienta KJ: CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis. Cytokine Growth Factor Rev. 21:41–48. 2010. View Article : Google Scholar :

48 

Fujimoto H, Sangai T, Ishii G, et al: Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression. Int J Cancer. 125:1276–1284. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Ueno T, Toi M, Saji H, et al: Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angio-genesis, and survival in human breast cancer. Clin Cancer Res. 6:3282–3289. 2000.PubMed/NCBI

50 

Greenhough A, Smartt HJ, Moore AE, et al: The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis. 30:377–386. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Nakanishi Y, Nakatsuji M, Seno H, et al: COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps. Carcinogenesis. 32:1333–1339. 2011. View Article : Google Scholar : PubMed/NCBI

52 

Whiteside TL: Regulatory T cell subsets in human cancer: are they regulating for or against tumor progression? Cancer Immunol Immunother. 63:67–72. 2014. View Article : Google Scholar :

53 

Eruslanov E, Daurkin I, Ortiz J, Vieweg J and Kusmartsev S: Pivotal Advance: Tumor-mediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE2 catabolism in myeloid cells. J Leukoc Biol. 88:839–848. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Heusinkveld M, van Steenwijk PJdV, Goedemans R, et al: M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells. J Immunol. 187:1157–1165. 2011. View Article : Google Scholar : PubMed/NCBI

55 

Zhang W, Xu W and Xiong S: Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component. J Immunol. 187:1764–1777. 2011. View Article : Google Scholar : PubMed/NCBI

56 

Lawrence T and Natoli G: Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat Rev Immunol. 11:750–761. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Cai DJ and Li B: Ovarian cancer stem-like cells elicit the polarization of M2 macrophages. Mol Med Rep 11: 4685-4693, 2015.
APA
Zhang, Q., Cai, D., & Li, B. (2015). Ovarian cancer stem-like cells elicit the polarization of M2 macrophages. Molecular Medicine Reports, 11, 4685-4693. https://doi.org/10.3892/mmr.2015.3323
MLA
Zhang, Q., Cai, D., Li, B."Ovarian cancer stem-like cells elicit the polarization of M2 macrophages". Molecular Medicine Reports 11.6 (2015): 4685-4693.
Chicago
Zhang, Q., Cai, D., Li, B."Ovarian cancer stem-like cells elicit the polarization of M2 macrophages". Molecular Medicine Reports 11, no. 6 (2015): 4685-4693. https://doi.org/10.3892/mmr.2015.3323
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Cai DJ and Li B: Ovarian cancer stem-like cells elicit the polarization of M2 macrophages. Mol Med Rep 11: 4685-4693, 2015.
APA
Zhang, Q., Cai, D., & Li, B. (2015). Ovarian cancer stem-like cells elicit the polarization of M2 macrophages. Molecular Medicine Reports, 11, 4685-4693. https://doi.org/10.3892/mmr.2015.3323
MLA
Zhang, Q., Cai, D., Li, B."Ovarian cancer stem-like cells elicit the polarization of M2 macrophages". Molecular Medicine Reports 11.6 (2015): 4685-4693.
Chicago
Zhang, Q., Cai, D., Li, B."Ovarian cancer stem-like cells elicit the polarization of M2 macrophages". Molecular Medicine Reports 11, no. 6 (2015): 4685-4693. https://doi.org/10.3892/mmr.2015.3323
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