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Article

MicroRNA-181 targets Yin Yang 1 expression and inhibits cervical cancer progression

  • Authors:
    • Wen‑Yu Zhou
    • Jin‑Chan Chen
    • Ting‑Ting Jiao
    • Ning Hui
    • Xuan Qi
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China, Department of Obstetrics and Gynecology, Shanghai Chinese Armed Police Forces Hospital, Shanghai 200051, P.R. China
  • Pages: 4541-4546
    |
    Published online on: February 10, 2015
       https://doi.org/10.3892/mmr.2015.3324
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Abstract

Dysregulated expression of microRNAs (miRNAs) has been observed in numerous types of human cancer, including cervical cancer (CC). The present study aimed to elucidate the expression and roles of miR‑181 in cervical cancer tissues and cells. HeLa cells with a stable overexpression of miR‑181 were generated and injected subcutaneously into the front legs of nude mice. Functional assays revealed a reduced rate of proliferation and an enhanced rate of apoptosis following transfection of CC cells with miR‑181 mimics. In addition, miR‑181 also suppressed tumor growth in the nude mice. At the molecular level, it was found that Yin Yang 1, an oncogene in several types of human cancer, was negatively regulated by miR‑181. Therefore, the findings of the present study suggest that exogenous overexpression of miR‑181 may be a potential approach for the treatment of CC in the future.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou WY, Chen JC, Jiao TT, Hui N and Qi X: MicroRNA-181 targets Yin Yang 1 expression and inhibits cervical cancer progression. Mol Med Rep 11: 4541-4546, 2015.
APA
Zhou, W., Chen, J., Jiao, T., Hui, N., & Qi, X. (2015). MicroRNA-181 targets Yin Yang 1 expression and inhibits cervical cancer progression. Molecular Medicine Reports, 11, 4541-4546. https://doi.org/10.3892/mmr.2015.3324
MLA
Zhou, W., Chen, J., Jiao, T., Hui, N., Qi, X."MicroRNA-181 targets Yin Yang 1 expression and inhibits cervical cancer progression". Molecular Medicine Reports 11.6 (2015): 4541-4546.
Chicago
Zhou, W., Chen, J., Jiao, T., Hui, N., Qi, X."MicroRNA-181 targets Yin Yang 1 expression and inhibits cervical cancer progression". Molecular Medicine Reports 11, no. 6 (2015): 4541-4546. https://doi.org/10.3892/mmr.2015.3324
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou WY, Chen JC, Jiao TT, Hui N and Qi X: MicroRNA-181 targets Yin Yang 1 expression and inhibits cervical cancer progression. Mol Med Rep 11: 4541-4546, 2015.
APA
Zhou, W., Chen, J., Jiao, T., Hui, N., & Qi, X. (2015). MicroRNA-181 targets Yin Yang 1 expression and inhibits cervical cancer progression. Molecular Medicine Reports, 11, 4541-4546. https://doi.org/10.3892/mmr.2015.3324
MLA
Zhou, W., Chen, J., Jiao, T., Hui, N., Qi, X."MicroRNA-181 targets Yin Yang 1 expression and inhibits cervical cancer progression". Molecular Medicine Reports 11.6 (2015): 4541-4546.
Chicago
Zhou, W., Chen, J., Jiao, T., Hui, N., Qi, X."MicroRNA-181 targets Yin Yang 1 expression and inhibits cervical cancer progression". Molecular Medicine Reports 11, no. 6 (2015): 4541-4546. https://doi.org/10.3892/mmr.2015.3324
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