Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
June-2015 Volume 11 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2015 Volume 11 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Protective effect of Flt3L on organ structure during advanced multiorgan dysfunction syndrome in mice

  • Authors:
    • Guang Tian
    • Jiangyang Lu
    • Huiqin Guo
    • Qian Liu
    • Hongwei Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Affiliated Hospital of General Hospital of PLA, Beijing 100048, P.R. China, Department of Thoracic Surgery, Peking Union Medical College Hospital, Beijing 100730, P.R. China
    Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 4135-4141
    |
    Published online on: February 10, 2015
       https://doi.org/10.3892/mmr.2015.3328
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to examine whether fms‑related tyrosine kinase 3 ligand (Flt3L) protects the organs of mice with multiorgan dysfunction syndrome (MODS). Male C57BL/6 mice were randomly assigned to normal control, MODS and Flt3L treatment groups. The mouse models of MODS were established using intraperitoneal zymosan injections, followed by normal saline injections. The treatment group received 5 µg/kg Flt3L for seven days, beginning on day five following zymosan injection. On day 12, the mortality rates of the Flt3L treatment and the MODS groups were 7 and 18%, respectively. Marked pathological changes were observed in the liver, lungs, kidneys and heart of the mice with MODS, including degeneration and focal necrosis of parenchyma cells. Mild pathological changes were observed in different organs of the Flt3L‑treated mice. In the MODS group, the number of CD4+ T lymphocytes was significantly reduced, whereas the number of CD8+ T lymphocytes was significantly increased compared with that in the normal control group; thus, the CD4+/CD8+ ratio was reduced. In the Flt3L treatment group, the average number of CD4+ T lymphocytes was not significantly different to the average number of CD4+ T lymphocytes in the normal group. In conclusion, Flt3L administration improved the immune status and alleviated the organ damage in mice with late‑phase MODS.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J and Pinsky MR: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 29:1303–1310. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Lawrence K: Pediatric sepsis and multiorgan dysfunction syndrome: progress and continued challenges. Crit Care Nurs Clin North Am. 23:323–337. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Bone RC, Sibbald WJ and Sprung CL: The ACCP/SCCM consensus conference on sepsis and organ failure. Chest. 101:1481–1483. 1992. View Article : Google Scholar : PubMed/NCBI

4 

Davies MG and Hagen PO: Systemic inflammatory response syndrome. Br J Surg. 84:920–935. 1997. View Article : Google Scholar : PubMed/NCBI

5 

Shimada H, Moriwaki Y, Kurosawa H, et al: Inflammatory mediator and organ dysfunction syndrome. Nippon Geka Gakkai Zasshi. 99:490–496. 1998.In Japanese.

6 

Bone RC: Immunologic dissonance: a continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS). Ann Intern Med. 125:680–687. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Volk HD, Reinke P, Krausch D, et al: Monocyte deactivation - rationale for a new therapeutic strategy in sepsis. Intensive Care Med. 22(Suppl 4): S474–S481. 1996. View Article : Google Scholar

8 

Mentula P, Kylänpää-Bäck ML, Kemppainen E, et al: Decreased HLA (human leucocyte antigen)-DR expression on peripheral blood monocytes predicts the development of organ failure in patients with acute pancreatitis. Clin Sci (Lond). 105:409–417. 2003. View Article : Google Scholar

9 

Schefold JC: Measurement of monocytic HLA-DR (mHLA-DR) expression in patients with severe sepsis and septic shock: assessment of immune organ failure. Intensive Care Med. 36:1810–1812. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Hotchkiss RS, Swanson PE, Freeman BD, et al: Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med. 27:1230–1251. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Hotchkiss RS, Tinsley KW, Swanson PE, et al: Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol. 168:2493–2500. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Boomer JS, To K, Chang KC, et al: Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA. 306:2594–2605. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Reddy RC, Chen GH, Tekchandani PK and Standiford TJ: Sepsis-induced immunosuppression: from bad to worse. Immunol Res. 24:273–287. 2001. View Article : Google Scholar

14 

Monneret G, Debard AL, Venet F, et al: Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis. Crit Care Med. 31:2068–2071. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Jiangyang L, Qian L, Xiaohong W, et al: Changes of spleen dendritic cells in the terminal stage of multiple organ dysfunction syndrome. Acta Biomed. 82:146–153. 2011.

16 

Shurin MR, Pandharipande PP, Zorina TD, et al: FLT3 ligand induces the generation of functionally active dendritic cells in mice. Cell Immunol. 179:174–184. 1997. View Article : Google Scholar : PubMed/NCBI

17 

Sakabe H, Kimura T, Zeng Z, et al: Haematopoietic action of flt3 ligand on cord blood-derived CD34-positive cells expressing different levels of flt3 or c-kit tyrosine kinase receptor: comparison with stem cell factor. Eur J Haematol. 60:297–306. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Shaw SG, Maung AA, Steptoe RJ, Thomson AW and Vujanovic NL: Expansion of functional NK cells in multiple tissue compartments of mice treated with Flt3-ligand: implications for anti-cancer and anti-viral therapy. J Immunol. 161:2817–2824. 1998.PubMed/NCBI

19 

Wysocka M, Montaner LJ and Karp CL: Flt3 ligand treatment reverses endotoxin tolerance-related immunoparalysis. J Immunol. 174:7398–7402. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Flohé SB, Agrawal H, Schmitz D, Gertz M, Flohé S and Schade FU: Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective Th1-type immune response. J Leukoc Biol. 79:473–481. 2006. View Article : Google Scholar

21 

Fujita S, Seino K, Sato K, et al: Regulatory dendritic cells act as regulators of acute lethal systemic inflammatory response. Blood. 107:3656–3664. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Wallet MA, Sen P and Tisch R: Immunoregulation of Dendritic Cells. Clin Med Res. 3:166–175. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Volman TJ, Hendriks T and Goris RJ: Zymosan induced generalized inflammation: experimental studies into mechanisms leading to multiple organ dysfunction syndrome. Shock. 23:291–297. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Zhang M, Tang H, Guo Z, et al: Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat Immunol. 5:1124–1133. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Tan C, Reddy V, Dannull J, et al: Impact of anti-CD25 monoclonal antibody on dendritic cell-tumor fusion vaccine efficacy in a murine melanoma model. J Transl Med. 11:1482013. View Article : Google Scholar : PubMed/NCBI

26 

Fan X, Ye M, Xue B, Ke Y, Wong CK and Xie Y: Human dendritic cells engineered to secrete interleukin-18 activate MAGE-A3-specific cytotoxic T lymphocytes in vitro. Immunol Invest. 41:469–483. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tian G, Lu J, Guo H, Liu Q and Wang H: Protective effect of Flt3L on organ structure during advanced multiorgan dysfunction syndrome in mice. Mol Med Rep 11: 4135-4141, 2015.
APA
Tian, G., Lu, J., Guo, H., Liu, Q., & Wang, H. (2015). Protective effect of Flt3L on organ structure during advanced multiorgan dysfunction syndrome in mice. Molecular Medicine Reports, 11, 4135-4141. https://doi.org/10.3892/mmr.2015.3328
MLA
Tian, G., Lu, J., Guo, H., Liu, Q., Wang, H."Protective effect of Flt3L on organ structure during advanced multiorgan dysfunction syndrome in mice". Molecular Medicine Reports 11.6 (2015): 4135-4141.
Chicago
Tian, G., Lu, J., Guo, H., Liu, Q., Wang, H."Protective effect of Flt3L on organ structure during advanced multiorgan dysfunction syndrome in mice". Molecular Medicine Reports 11, no. 6 (2015): 4135-4141. https://doi.org/10.3892/mmr.2015.3328
Copy and paste a formatted citation
x
Spandidos Publications style
Tian G, Lu J, Guo H, Liu Q and Wang H: Protective effect of Flt3L on organ structure during advanced multiorgan dysfunction syndrome in mice. Mol Med Rep 11: 4135-4141, 2015.
APA
Tian, G., Lu, J., Guo, H., Liu, Q., & Wang, H. (2015). Protective effect of Flt3L on organ structure during advanced multiorgan dysfunction syndrome in mice. Molecular Medicine Reports, 11, 4135-4141. https://doi.org/10.3892/mmr.2015.3328
MLA
Tian, G., Lu, J., Guo, H., Liu, Q., Wang, H."Protective effect of Flt3L on organ structure during advanced multiorgan dysfunction syndrome in mice". Molecular Medicine Reports 11.6 (2015): 4135-4141.
Chicago
Tian, G., Lu, J., Guo, H., Liu, Q., Wang, H."Protective effect of Flt3L on organ structure during advanced multiorgan dysfunction syndrome in mice". Molecular Medicine Reports 11, no. 6 (2015): 4135-4141. https://doi.org/10.3892/mmr.2015.3328
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team