Inhibition of monocyte chemoattractant peptide-1 decreases secondary spinal cord injury

Zhang,Xuesong; Chen,Chao; Ma,Shengzhong; Wang,Yan; Zhang,Xuelian; Su,Xiaojing

doi:10.3892/mmr.2015.3330

June-2015 Volume 11 Issue 6

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June-2015 Volume 11 Issue 6

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Article

Inhibition of monocyte chemoattractant peptide-1 decreases secondary spinal cord injury

Authors:
- Xuesong Zhang
- Chao Chen
- Shengzhong Ma
- Yan Wang
- Xuelian Zhang
- Xiaojing Su
View Affiliations / Copyright

Affiliations: Spine Department, General Hospital of PLA, Beijing 100853, P.R. China, Spine Department, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China, Endocrine Department, China-Japan Friendship Hospital, Beijing 100029, P.R. China
Pages: 4262-4266
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Published online on: February 11, 2015

https://doi.org/10.3892/mmr.2015.3330
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Abstract

Previous studies have suggested that impairment secondary to mechanical injury is a major cause of irreversible damage to the spinal cord. Inflammatory chemokines have been shown to play an important role in the pathological and physiological consequences of secondary spinal cord injury (SCI). The aim of the present study was to evaluate how changes in the expression levels of the cellular chemokine, monocyte chemoattractant peptide-1 (MCP-1), and the chemotaxis of inflammatory cells (monocytes and macrophages) are involved in the process of SCI. RNA interference methods were used to study the mechanisms that protect residual neurons after SCI in an attempt to explore novel, early interventions for managing SCI. Our results suggested that inhibiting inflammation alleviates nerve cell injury caused by apoptosis and provides a potentially important approach for the future treatment of secondary SCI.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Inhibition of monocyte chemoattractant peptide-1 decreases secondary spinal cord injury

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