Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
June-2015 Volume 11 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2015 Volume 11 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Association between oxidative DNA damage and the expression of 8-oxoguanine DNA glycosylase 1 in lung epithelial cells of neonatal rats exposed to hyperoxia

  • Authors:
    • Linlin Jin
    • Haiping Yang
    • Jianhua Fu
    • Xindong Xue
    • Li Yao
    • Lin Qiao
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
    Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 4079-4086
    |
    Published online on: February 12, 2015
       https://doi.org/10.3892/mmr.2015.3339
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Previous studies have demonstrated that oxidative stress‑induced lung injury is involved in the occurrence and developmental process of bronchopulmonary dysplasia (BPD). The present study assessed whether oxidative DNA damage occurs in the early stages of hyperoxia‑induced BPD in neonatal rats and evaluated the expression and localization of the DNA repair gene, 8‑oxoguanine DNA glycosylase 1 (OGG1), upon exposure to hyperoxia. Neonatal rats and primary cultured neonatal rat alveolar epithelial type II (AECII) cells were exposed to hyperoxia (90% O2) or normoxia (21% O2) and the expression levels of 8‑hydroxy‑2'‑deoxyguanosine (8‑OHdG) in the lung tissues and AECII cells were determined using a competitive enzyme‑linked immunosorbent assay. DNA strand breaks in the AECII cells were detected using a comet assay. The expression and localization of the OGG1 protein in the lung tissues and AECII cells were determined by immunofluorescence confocal microscopy and western blotting. The mRNA expression levels of OGG1 in the lung tissues and AECII cells were determined by reverse transcription polymerase chain reaction. The expression of 8‑OHdG was elevated in the hyperoxia‑exposed neonatal rat lung tissue and the AECII cells compared with the normoxic controls. The occurrence of DNA strand breaks in the AECII cells increased with increasing duration of hyperoxia exposure. The protein expression of OGG1 was significantly increased in the hyperoxia‑exposed lung tissues and AECII cells, with OGG1 preferentially localized to the cytoplasm. No concomitant increase in the mRNA expression of OGG1 was detected. These results revealed that oxidative DNA damage occurred in lung epithelial cells during early‑stage BPD, as confirmed by in vitro and in vivo hyperoxia exposure experiments, and the increased expression of OGG1 was associated with this process.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Jobe AH and Bancalari E: Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 163:1723–1729. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Bancalari E, Claure N and Sosenko IR: Bronchopulmonary dysplasia: Changes in pathogenesis, epidemiology and definition. Semin Neonatol. 8:63–71. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Greenough A, Cox S, Alexander J, et al: Health care utilisation of infants with chronic lung disease, related to hospitalisation for RSV infection. Arch Dis Child. 85:463–468. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Saigal S and Doyle LW: An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet. 371:261–269. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Reyburn B, Martin RJ, Prakash YS, et al: Mechanisms of injury to the preterm lung and airway: implications for long-term pulmonary outcome. Neonatology. 101:345–352. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Van Marter LJ: Progress in discovery and evaluation of treatments to prevent bronchopulmonary dysplasia. Biol Neonate. 89:303–312. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Coalson JJ: Pathology of bronchopulmonary dysplasia. Semin Perinatol. 30:179–184. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Northway WH Jr, Rosan RC and Porter DY: Pulmonary disease following respirator therapy of hyaline-membrane disease Bronchopulmonary dysplasia. N Engl J Med. 276:357–368. 1967. View Article : Google Scholar : PubMed/NCBI

9 

Gerschman R, Gilbert DL, Nye SW, et al: Oxygen poisoning and x-irradiation: a mechanism in common. Science. 119:623–626. 1954. View Article : Google Scholar : PubMed/NCBI

10 

Jianhua F and Xindong X: Study on oxidation and antioxidation in lung tissue of premature rat with hyperoxia-induced chronic lung. Chin J Perinat Med. 7:361–363. 2004.

11 

Jianhua Fu and Xindong Xue: Changes of ultrastructure and oxidative stress reaction of lungs in premature rats with chronic lung disease induced by hyperoxia. Chin J Contemp Pediatrics. 6:23–26. 2004.

12 

Cai Q and Xu MY: Protective effect of rosiglitazone against hyperoxia-induced lung injury in neonatal rats. Zhongguo Dang Dai Er Ke Za Zhi. 14:301–305. 2012.In Chinese. PubMed/NCBI

13 

Tayman C, Cekmez F, Kafa IM, et al: Protective effects of nigella sativa oil in hyperoxia-induced lung injury. Arch Bronconeumol. 49:15–21. 2013. View Article : Google Scholar

14 

Jackson SP and Bartek J: The DNA-damage response in human biology and disease. Nature. 461:1071–1078. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Mitra S, Boldogh I, Izumi T, et al: Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage. Environ Mol Mutagen. 38:180–190. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Mitra S, Hazra TK, Roy R, et al: Complexities of DNA base excision repair in mammalian cells. Mol Cells. 7:305–312. 1997.PubMed/NCBI

17 

Kruman II: Why do neurons enter the cell cycle? Cell Cycle. 3:769–773. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Hill JW, Hazra TK, Izumi T, et al: Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair. Nucleic Acids Res. 29:430–438. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Vidal AE, Hickson ID, Boiteux S, et al: Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP endonuclease: bypass of the AP lyase activity step. Nucleic Acids Res. 29:1285–1292. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Ruchko M, Gorodnya O, LeDoux SP, et al: Mitochondrial DNA damage triggers mitochondrial dysfunction and apoptosis in oxidant-challenged lung endothelial cells. Am J Physiol Lung Cell Mol Physiol. 288:L530–L535. 2005. View Article : Google Scholar

21 

Ruchko MV, Gorodnya OM, Zuleta A, et al: The DNA glycosylase Ogg1 defends against oxidant-induced mtDNA damage and apoptosis in pulmonary artery endothelial cells. Free Radical Biol Med. 50:1107–1113. 2011. View Article : Google Scholar

22 

Miller-Pinsler L and Wells PG: Deficient DNA repair exacerbates ethanol-initiated DNA oxidation and embryopathies in ogg1 knockout mice: gender risk and protection by a free radical spin trapping agent. Arch Toxicol. Oct 30–2014.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

23 

Auten RL, Whorton MH and Nicholas Mason S: Blocking neutrophil influx reduces DNA damage in hyperoxia-exposed newborn rat lung. Am J Respir Cell Mol Biol. 26:391–397. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Zhang QY, Fu JH and Xue XD: Primary cell culture and identification of alveolar epithelial cell isolated from neonatal rats. Zhongguo Xinshengerke Zazhi. 25:339–341. 2010.

25 

Li T, Koshy S and Folkesson HG: Involvement of aENaC and Nedd4-2 in the conversion from lung fluid secretion to fluid absorption at birth in the rat as assayed by RNA interference analysis. Am J Physiol Lung Cell Mol Physiol. 293:L1069–L1078. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Ji W, Fu J, Nie H, et al: Expression and activity of epithelial sodium channel in hyperoxia-induced bronchopulmonary dysplasia in neonatal rats. Pediatr Int. 54:735–742. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Motalleb G, Pourrahmat E, Najafi S, et al: Epidermal growth factor receptor gene expression evaluation in colorectal cancer patients. Indian J Cancer. 51:358–362. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Welty SE: Is there a role for antioxidant therapy in bronchopulmonary dysplasia? J Nutr. 131:947S–950S. 2001.PubMed/NCBI

29 

Sampath V, Garland JS, Helbing D, et al: Antioxidant response genes sequence variants and BPD susceptibility in VLBW infants. Pediatr Res. Dec 17–2014.Epub ahead of print. PubMed/NCBI

30 

Sandal G, Mutlu B, Uras N, et al: Evaluation of treatment with hydrocortisone on oxidant/antioxidant system in preterm infants with BPD. Eur Rev Med Pharmacol Sci. 17:2594–2597. 2013.PubMed/NCBI

31 

Groneck P, Reuss D, Götze-Speer B, et al: Effects of dexamethasone on chemotactic activity and inflammatory mediators in tracheobronchial aspirates of preterm infants at risk for chronic lung disease. J Pediatr. 122:938–944. 1993. View Article : Google Scholar : PubMed/NCBI

32 

Bracci R: Free oxygen radicals and surfactant. Biol Neonate. 71:23–27. 1997. View Article : Google Scholar : PubMed/NCBI

33 

Polglase GR, Dalton RG, Nitsos I, et al: Pulmonary vascular and alveolar development in preterm lambs chronically colonized with Ureaplasma parvum. Am J Physiol Lung Cell Mol Physiol. 299:L232–L241. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Watts JL, Milner R, Zipursky A, et al: Failure of supplementation with vitamin E to prevent bronchopulmonary dysplasia in infants less than 1,500 g birth weight. Eur Respir J. 4:188–190. 1991.PubMed/NCBI

35 

Davis JM, Rosenfeld WN, Richter SE, et al: Safety and pharmacokinetics of multiple doses of recombinant human CuZn superoxide dismutase administered intratracheally to premature neonates with respiratory distress syndrome. Pediatrics. 100:24–30. 1997. View Article : Google Scholar : PubMed/NCBI

36 

Ozdemir R, Yurttutan S, Talim B, et al: Colchicine protects against hyperoxic lung injury in neonatal rats. Neonatology. 102:265–269. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Ahola T, Lapatto R, Raivio KO, et al: N-acetylcysteine does not prevent bronchopulmonary dysplasia in immature infants: a randomized controlled trial. J Pediatr. 143:713–719. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Maniscalco WM, Watkins RH, Roper JM, et al: Hyperoxic ventilated premature baboons have increased p53, oxidant DNA damage and decreased VEGF expression. Pediatr Res. 58:549–556. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Kannan S, Pang H, Foster DC, et al: Human 8-oxoguanine DNA glycosylase increases resistance to hyperoxic cytotoxicity in lung epithelial cells and involvement with altered MAPK activity. Cell Death Differ. 13:311–323. 2006. View Article : Google Scholar

40 

Cooke MS, Evans MD, Dizdaroglu M, et al: Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J. 17:1195–1214. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Zhang Y, Ouyang S, Zhang L, et al: Oxygen-induced changes in mitochondrial DNA and DNA repair enzymes in aging rat lens. Mech Ageing Dev. 131:666–673. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Bohr VA, Stevnsner T and de Souza-Pinto NC: Mitochondrial DNA repair of oxidative damage in mammalian cells. Gene. 286:127–134. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Yakes FM and Van Houten B: Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci USA. 94:514–519. 1997. View Article : Google Scholar : PubMed/NCBI

44 

He YH, Xu Y, Kobune M, et al: Escherichia coli FPG and human OGG1 reduce DNA damage and cytotoxicity by BCNU in human lung cells. Am J Physiol Lung Cell Mol Physiol. 282:L50–L55. 2002. View Article : Google Scholar

45 

Ma H, Wang J, Abdel-Rahman SZ, et al: Oxidative DNA damage and its repair in rat spleen following subchronic exposure to aniline. Toxicol Appl Pharmacol. 233:247–253. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jin L, Yang H, Fu J, Xue X, Yao L and Qiao L: Association between oxidative DNA damage and the expression of 8-oxoguanine DNA glycosylase 1 in lung epithelial cells of neonatal rats exposed to hyperoxia. Mol Med Rep 11: 4079-4086, 2015.
APA
Jin, L., Yang, H., Fu, J., Xue, X., Yao, L., & Qiao, L. (2015). Association between oxidative DNA damage and the expression of 8-oxoguanine DNA glycosylase 1 in lung epithelial cells of neonatal rats exposed to hyperoxia. Molecular Medicine Reports, 11, 4079-4086. https://doi.org/10.3892/mmr.2015.3339
MLA
Jin, L., Yang, H., Fu, J., Xue, X., Yao, L., Qiao, L."Association between oxidative DNA damage and the expression of 8-oxoguanine DNA glycosylase 1 in lung epithelial cells of neonatal rats exposed to hyperoxia". Molecular Medicine Reports 11.6 (2015): 4079-4086.
Chicago
Jin, L., Yang, H., Fu, J., Xue, X., Yao, L., Qiao, L."Association between oxidative DNA damage and the expression of 8-oxoguanine DNA glycosylase 1 in lung epithelial cells of neonatal rats exposed to hyperoxia". Molecular Medicine Reports 11, no. 6 (2015): 4079-4086. https://doi.org/10.3892/mmr.2015.3339
Copy and paste a formatted citation
x
Spandidos Publications style
Jin L, Yang H, Fu J, Xue X, Yao L and Qiao L: Association between oxidative DNA damage and the expression of 8-oxoguanine DNA glycosylase 1 in lung epithelial cells of neonatal rats exposed to hyperoxia. Mol Med Rep 11: 4079-4086, 2015.
APA
Jin, L., Yang, H., Fu, J., Xue, X., Yao, L., & Qiao, L. (2015). Association between oxidative DNA damage and the expression of 8-oxoguanine DNA glycosylase 1 in lung epithelial cells of neonatal rats exposed to hyperoxia. Molecular Medicine Reports, 11, 4079-4086. https://doi.org/10.3892/mmr.2015.3339
MLA
Jin, L., Yang, H., Fu, J., Xue, X., Yao, L., Qiao, L."Association between oxidative DNA damage and the expression of 8-oxoguanine DNA glycosylase 1 in lung epithelial cells of neonatal rats exposed to hyperoxia". Molecular Medicine Reports 11.6 (2015): 4079-4086.
Chicago
Jin, L., Yang, H., Fu, J., Xue, X., Yao, L., Qiao, L."Association between oxidative DNA damage and the expression of 8-oxoguanine DNA glycosylase 1 in lung epithelial cells of neonatal rats exposed to hyperoxia". Molecular Medicine Reports 11, no. 6 (2015): 4079-4086. https://doi.org/10.3892/mmr.2015.3339
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team