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Article

Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus

  • Authors:
    • Dae‑Ki Joung
    • Sung‑Hoon Choi
    • Ok‑Hwa Kang
    • Sung‑Bae Kim
    • Su‑Hyun Mun
    • Yun‑Soo Seo
    • Da-Hye Kang
    • Ryong Gong
    • Dong‑Won Shin
    • Youn-Chul Kim
    • Dong‑Yeul Kwon
  • View Affiliations / Copyright

    Affiliations: College of Pharmacy and Wonkwang‑Oriental Medicines Research Institute, Institute of Biotechnology, Wonkwang University, Iksan, Jeonbuk 570‑749, Republic of Korea, BK21 Plus Team, Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570‑749, Republic of Korea, Department of Oriental Medicine Resources, Sunchon National University, Sunchon, Jeonnam 540‑742, Republic of Korea, Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University, Iksan 570-749, Republic of Korea
  • Pages: 663-667
    |
    Published online on: February 12, 2015
       https://doi.org/10.3892/mmr.2015.3345
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Abstract

Methicillin‑resistant Staphylococcus aureus (MRSA) infection is a serious clinical problem worldwide. The aim of the present study was to examine the antimicrobial activity of oxyresveratrol (ORV) against MRSA. The antimicrobial activity of ORV was evaluated against three strains of MRSA and one methicillin‑susceptible S. aureus (MSSA) strain using a minimal inhibitory concentration (MIC) assay, MTT colorimetric assay, checkerboard dilution test and time‑kill assay. The MIC of ORV for all strains was moderate at 125 µg/ml. Of note, the antimicrobial activity and fractional inhibitory concentration index values of ORV were markedly increased in the presence of a non‑growth inhibitory dose of certain antibiotics. Time‑kill curves revealed that a combination of ORV with ciprofloxacin or with gentamicin reduced bacterial counts to below the lowest detectable limit after 24 h. These effective combinations may be used as potential antimicrobial regimens for use in the management of MRSA.
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Copy and paste a formatted citation
Spandidos Publications style
Joung DK, Choi SH, Kang OH, Kim SB, Mun SH, Seo YS, Kang D, Gong R, Shin DW, Kim Y, Kim Y, et al: Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus. Mol Med Rep 12: 663-667, 2015.
APA
Joung, D., Choi, S., Kang, O., Kim, S., Mun, S., Seo, Y. ... Kwon, D. (2015). Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus. Molecular Medicine Reports, 12, 663-667. https://doi.org/10.3892/mmr.2015.3345
MLA
Joung, D., Choi, S., Kang, O., Kim, S., Mun, S., Seo, Y., Kang, D., Gong, R., Shin, D., Kim, Y., Kwon, D."Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus". Molecular Medicine Reports 12.1 (2015): 663-667.
Chicago
Joung, D., Choi, S., Kang, O., Kim, S., Mun, S., Seo, Y., Kang, D., Gong, R., Shin, D., Kim, Y., Kwon, D."Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus". Molecular Medicine Reports 12, no. 1 (2015): 663-667. https://doi.org/10.3892/mmr.2015.3345
Copy and paste a formatted citation
x
Spandidos Publications style
Joung DK, Choi SH, Kang OH, Kim SB, Mun SH, Seo YS, Kang D, Gong R, Shin DW, Kim Y, Kim Y, et al: Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus. Mol Med Rep 12: 663-667, 2015.
APA
Joung, D., Choi, S., Kang, O., Kim, S., Mun, S., Seo, Y. ... Kwon, D. (2015). Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus. Molecular Medicine Reports, 12, 663-667. https://doi.org/10.3892/mmr.2015.3345
MLA
Joung, D., Choi, S., Kang, O., Kim, S., Mun, S., Seo, Y., Kang, D., Gong, R., Shin, D., Kim, Y., Kwon, D."Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus". Molecular Medicine Reports 12.1 (2015): 663-667.
Chicago
Joung, D., Choi, S., Kang, O., Kim, S., Mun, S., Seo, Y., Kang, D., Gong, R., Shin, D., Kim, Y., Kwon, D."Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus". Molecular Medicine Reports 12, no. 1 (2015): 663-667. https://doi.org/10.3892/mmr.2015.3345
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