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Article

FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7

  • Authors:
    • Hong-Jun Hu
    • Li-Guo Zhang
    • Zhen-Hua Wang
    • Xi-Xi Guo
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Tumor Surgery 2, Xinxiang Central Hospital, Xinxiang, Henan 453000, P.R. China
  • Pages: 575-580
    |
    Published online on: February 17, 2015
       https://doi.org/10.3892/mmr.2015.3362
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Abstract

Emerging evidence has suggested that misregulation of oncogenes and/or tumor suppressors has a crucial role in the development of lung carcinoma. The present study demonstrated that the expression levels of forkhead box O6 (FOXO6) were downregulated in lung cancer tissue samples, as compared with those in adjacent normal tissue. Overexpression of FOXO6 inhibited the proliferation of A549 human lung cancer cells, whereas knockdown of endogenous FOXO6 expression enhanced cell proliferation. Furthermore, ectopic FOXO6 expression induced the expression of ubiquitin‑specific‑processing protease 7 (USP7). As a result of this regulation, FOXO6 overexpression led to an elevation of p53 protein expression levels in A549 cells. In conclusion, the results of the present study indicated that the FOXO6/USP7 molecular network has an important role in the regulation of lung cancer development.
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Copy and paste a formatted citation
Spandidos Publications style
Hu H, Zhang L, Wang Z and Guo X: FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7. Mol Med Rep 12: 575-580, 2015.
APA
Hu, H., Zhang, L., Wang, Z., & Guo, X. (2015). FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7. Molecular Medicine Reports, 12, 575-580. https://doi.org/10.3892/mmr.2015.3362
MLA
Hu, H., Zhang, L., Wang, Z., Guo, X."FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7". Molecular Medicine Reports 12.1 (2015): 575-580.
Chicago
Hu, H., Zhang, L., Wang, Z., Guo, X."FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7". Molecular Medicine Reports 12, no. 1 (2015): 575-580. https://doi.org/10.3892/mmr.2015.3362
Copy and paste a formatted citation
x
Spandidos Publications style
Hu H, Zhang L, Wang Z and Guo X: FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7. Mol Med Rep 12: 575-580, 2015.
APA
Hu, H., Zhang, L., Wang, Z., & Guo, X. (2015). FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7. Molecular Medicine Reports, 12, 575-580. https://doi.org/10.3892/mmr.2015.3362
MLA
Hu, H., Zhang, L., Wang, Z., Guo, X."FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7". Molecular Medicine Reports 12.1 (2015): 575-580.
Chicago
Hu, H., Zhang, L., Wang, Z., Guo, X."FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7". Molecular Medicine Reports 12, no. 1 (2015): 575-580. https://doi.org/10.3892/mmr.2015.3362
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