Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-2015 Volume 12 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2015 Volume 12 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Vasoactive intestinal peptide induces CD14+HLA-DR‑/low myeloid-derived suppressor cells in gastric cancer

  • Authors:
    • Gang Li
    • Ke Wu
    • Kaixiong Tao
    • Xiaoming Lu
    • Jianhua Ma
    • Zhengqiang Mao
    • Hang Li
    • Liang Shi
    • Jing Li
    • Yanfeng Niu
    • Fan Xiang
    • Guobin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Department of Surgery Oncology, Central Hospital, Xinxiang, Henan 453000, P.R. China, Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Department of Gerontology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
  • Pages: 760-768
    |
    Published online on: February 18, 2015
       https://doi.org/10.3892/mmr.2015.3374
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Myeloid‑derived suppressor cells (MDSCs) are a heterogeneous group of cells, which have been revealed to inhibit T‑cell responses in tumor‑bearing mice. In addition, a number of immune suppressive mechanisms have linked MDSCs and the development of human cancer. However, the role of MDSCs in human gastric cancer tissue remains to be elucidated as specific markers are lacking. Therefore, the aim of the present study was to investigate the frequency and immune suppressive function of MDSCs denoted in the present study as cluster of differentiation 14 (CD14)+human leukocyte antigen (HLA)‑DR‑/low in gastric cancer patients. In the present study, MDSCs were directly isolated and characterized from the tumor and adjacent normal tissue of gastric cancer patients. Functional analysis of the CD14+HLA‑DR‑/low MDSCs co‑cultured with allogeneic CD4+ T cells were performed and compared with controls. In addition, the interferon‑γ (IFN‑γ) and interleukin (IL)‑2 production was compared in order to investigate the capacity of vasoactive intestinal peptide (VIP) to induce CD14+HLA‑DR‑/low MDSC‑mediated CD4+ T‑cell dysfunction and whether IL‑10 secretion is involved in this mechanism. As a result, the quantity of CD14+HLA‑DR‑/low cells in tumor tissue from gastric cancer patients was significantly higher than that in the adjacent normal tissue. In addition, CD14+HLA‑DR‑/low MDSCs isolated from tumor tissue were observed to inhibit the CD4+ T‑cells' immune responses in comparison with those from the adjacent normal tissue. Furthermore, VIP was able to induce the differentiation of CD14+ mononuclear cells isolated from healthy donor peripheral blood mononuclear cells into activated MDSC cells. Of note, the immunosuppressive effect of VIP‑induced CD14+HLA‑DR‑/low MDSCs on CD4+ T cells was mediated by IL‑10 secretion, which was demonstrated in the subsequent decrease of IFN‑γ and IL‑2 production. In conclusion, CD14+HLA‑DR‑/low cells were significantly increased in gastric cancer tissue and were shown to have a critical role in CD4+T‑cell immunosuppression. In addition, VIP as a novel cytokine may induce the differentiation of CD14+ mononuclear cells towards CD14+HLA‑DR‑/low MDSCs. An improved understanding of phenotypic heterogeneity and the mechanism of generation of MDSCs in gastric cancer patients is important in the design of effective immunotherapeutic strategies.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Almand B, Clark JI, Nikitina E, et al: Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. J Immunol. 166:678–689. 2001. View Article : Google Scholar

2 

Bronte V, Serafini P, Apolloni E and Zanovello P: Tumor-induced immune dysfunctions caused by myeloid suppressor cells. J Immunother. 24:431–446. 2001. View Article : Google Scholar

3 

Young MR, Petruzzelli GJ, Kolesiak K, Achille N, Lathers DM and Gabrilovich DI: Human squamous cell carcinomas of the head and neck chemoattract immune suppressive CD34(+) progenitor cells. Hum Immunol. 62:332–341. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Huang A, Zhang B, Wang B, Zhang F, Fan KX and Guo YJ: Increased CD14(+)HLA-DR (−/low) myeloid-derived suppressor cells correlate with extrathoracic metastasis and poor response to chemotherapy in non-small cell lung cancer patients. Cancer Immunol Immunother. 62:1439–1451. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Zea AH, Rodriguez PC, Atkins MB, et al: Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion. Cancer Res. 65:3044–3048. 2005.PubMed/NCBI

6 

Hanson EM, Clements VK, Sinha P, Ilkovitch D and Ostrand-Rosenberg S: Myeloid-derived suppressor cells downregulate L-selectin expression on CD4+ and CD8+ T cells. J Immunol. 183:937–944. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Gabrilovich DI and Nagaraj S: Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. 9:162–174. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Duffy A, Zhao F, Haile L, et al: Comparative analysis of monocytic and granulocytic myeloid-derived suppressor cell subsets in patients with gastrointestinal malignancies. Cancer Immunol Immunother. 62:299–307. 2013. View Article : Google Scholar

9 

Hoechst B, Ormandy LA, Ballmaier M, et al: A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells. Gastroenterology. 135:234–243. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Khaled YS, Ammori BJ and Elkord E: Myeloid-derived suppressor cells in cancer: recent progress and prospects. Immunol Cell Biol. 91:493–502. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Lechner MG, Liebertz DJ and Epstein AL: Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells. J Immunol. 185:2273–2284. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Kusmartsev S and Gabrilovich DI: Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancer. Cancer Metastasis Rev. 25:323–331. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Fernandez-Martinez AB, Collado B, Bajo AM, Sanchez-Chapado M, Prieto JC and Carmena MJ: Vasoactive intestinal peptide induces cyclooxygenase-2 expression through nuclear factor-kappaB in human prostate cell lines Differential time-dependent responses in cancer progression. Mol Cell Endocrinol. 270:8–16. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Valdehita A, Carmena MJ, Bajo AM and Prieto JC: RNA interference-directed silencing of VPAC1 receptor inhibits VIP effects on both EGFR and HER2 transactivation and VEGF secretion in human breast cancer cells. Mol Cell Endocrinol. 348:241–246. 2012. View Article : Google Scholar

15 

Sotomayor S, Carmena MJ, Schally AV, et al: Transactivation of HER2 by vasoactive intestinal peptide in experimental prostate cancer: Antagonistic action of an analog of growth-hormone-releasing hormone. Int J Oncol. 31:1223–1230. 2007.PubMed/NCBI

16 

Couvineau A and Laburthe M: VPAC receptors: structure, molecular pharmacology and interaction with accessory proteins. Br J Pharmacol. 166:42–50. 2012. View Article : Google Scholar :

17 

Laburthe M, Couvineau A and Tan V: Class II G protein-coupled receptors for VIP and PACAP: structure, models of activation and pharmacology. Peptides. 28:1631–1639. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Pozo D, Anderson P and Gonzalez-Rey E: Induction of alloantigen-specific human T regulatory cells by vasoactive intestinal peptide. J Immunol. 183:4346–4359. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Wu K, Kryczek I, Chen L, Zou W and Welling TH: Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions. Cancer Res. 69:8067–8075. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Kryczek I, Wu K, Zhao E, et al: IL-17+ regulatory T cells in the microenvironments of chronic inflammation and cancer. J Immunol. 186:4388–4395. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Vuk-Pavlovic S, Bulur PA, Lin Y, et al: Immunosuppressive CD14+HLA-DRlow/- monocytes in prostate cancer. Prostate. 70:443–455. 2010.

22 

Lechner MG, Megiel C, Russell SM, et al: Functional characterization of human Cd33+ and Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines. J Translat Med. 9:902011. View Article : Google Scholar

23 

Youn JI and Gabrilovich DI: The biology of myeloid-derived suppressor cells: the blessing and the curse of morphological and functional heterogeneity. Eur J Immunol. 40:2969–2975. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Li JM, Southerland L, Hossain MS, et al: Absence of vasoactive intestinal peptide expression in hematopoietic cells enhances Th1 polarization and antiviral immunity in mice. J Immunol. 187:1057–1065. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Sinha P, Clements VK, Bunt SK, Albelda SM and Ostrand-Rosenberg S: Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response. J Immunol. 179:977–983. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Huang B, Pan PY, Li Q, et al: Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res. 66:1123–1131. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Porembka MR, Mitchem JB, Belt BA, et al: Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth. Cancer Immunol Immunother. 61:1373–1385. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Movahedi K, Guilliams M, Van den Bossche J, et al: Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood. 111:4233–4244. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Youn JI, Nagaraj S, Collazo M and Gabrilovich DI: Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J Immunol. 181:5791–5802. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Poschke I, Mougiakakos D, Hansson J, Masucci GV and Kiessling R: Immature immunosuppressive CD14+HLA-DR−/low cells in melanoma patients are Stat3hi and overexpress CD80, CD83 and DC-sign. Cancer Res. 70:4335–4345. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Mantovani A, Sozzani S, Locati M, Allavena P and Sica A: Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23:549–555. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Colombo MP and Piconese S: Regulatory-T-cell inhibition versus depletion: the right choice in cancer immunotherapy. Nat Rev Cancer. 7:880–887. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Brimnes MK, Vangsted AJ, Knudsen LM, et al: Increased level of both CD4+FOXP3+ regulatory T cells and CD14+HLA-DR (−)/low myeloid-derived suppressor cells and decreased level of dendritic cells in patients with multiple myeloma. Scand J Immunol. 72:540–547. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Rodrigues JC, Gonzalez GC, Zhang L, et al: Normal human monocytes exposed to glioma cells acquire myeloid-derived suppressor cell-like properties. Neuro Oncol. 12:351–365. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Gonzalez-Rey E and Delgado M: Vasoactive intestinal peptide and regulatory T-cell induction: a new mechanism and therapeutic potential for immune homeostasis. Trends Mol Med. 13:241–251. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Szilasi M, Buglyo A, Treszl A, Kiss L, Schally AV and Halmos G: Gene expression of vasoactive intestinal peptide receptors in human lung cancer. Int J Oncol. 39:1019–1024. 2011.PubMed/NCBI

37 

Veljkovic M, Dopsaj V, Dopsaj M, et al: Physical activity and natural anti-VIP antibodies: potential role in breast and prostate cancer therapy. PloS one. 6:e283042011. View Article : Google Scholar : PubMed/NCBI

38 

Lippitz BE: Cytokine patterns in patients with cancer: a systematic review. Lancet Oncol. 14:e218–e228. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Boytim M1, Lilly P, Drouvalakis K, et al: A human class II MHC-derived peptide antagonizes phosphatidylinositol 3-kinase to block IL-2 signaling. J Clin Invest. 105:1447–1453. 2000. View Article : Google Scholar : PubMed/NCBI

40 

Szema AM, Hamidi SA, Golightly MG, Rueb TP and Chen JJ: VIP Regulates the Development & Proliferation of Treg in vivo in spleen. Allergy Asthma Clin Immunol. 7:192011. View Article : Google Scholar

41 

Dumitriu IE, Dunbar DR, Howie SE, Sethi T and Gregory CD: Human dendritic cells produce TGF-beta 1 under the influence of lung carcinoma cells and prime the differentiation of CD4+CD25+Foxp3+ regulatory T cells. J Immunol. 182:2795–2807. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Vicari AP, Chiodoni C, Vaure C, et al: Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibody. J Exp Med. 196:541–549. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Toscano MG, Delgado M, Kong W, Martin F, Skarica M and Ganea D: Dendritic cells transduced with lentiviral vectors expressing VIP differentiate into VIP-secreting tolerogenic-like DCs. Mol Ther. 18:1035–1045. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Laborde RR, Lin Y, Gustafson MP, Bulur PA and Dietz AB: Cancer vaccines in the world of immune suppressive monocytes (CD14HLA-DR Cells): The gateway to improved responses. Front Immunol. 5:1472014. View Article : Google Scholar

45 

Trinchieri G: Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol. 3:133–146. 2003. View Article : Google Scholar : PubMed/NCBI

46 

Williams LM, Ricchetti G, Sarma U, Smallie T and Foxwell BM: Interleukin-10 suppression of myeloid cell activation-a continuing puzzle. Immunology. 113:281–292. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Hu X, Chen J, Wang L and Ivashkiv LB: Crosstalk among Jak-STAT, Toll-like receptor and ITAM-dependent pathways in macrophage activation. J Leukoc Biol. 82:237–243. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Finbloom DS and Winestock KD: IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes. J Immunol. 155:1079–1090. 1995.PubMed/NCBI

49 

Kusmartsev S, Nagaraj S and Gabrilovich DI: Tumor-associated CD8+T cell tolerance induced by bone marrow-derived immature myeloid cells. J Immunol. 175:4583–4592. 2005. View Article : Google Scholar : PubMed/NCBI

50 

Gabitass RF, Annels NE, Stocken DD, Pandha HA and Middleton GW: Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13. Cancer Immunol Immunother. 60:1419–1430. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li G, Wu K, Tao K, Lu X, Ma J, Mao Z, Li H, Shi L, Li J, Niu Y, Niu Y, et al: Vasoactive intestinal peptide induces CD14+HLA-DR‑/low myeloid-derived suppressor cells in gastric cancer. Mol Med Rep 12: 760-768, 2015.
APA
Li, G., Wu, K., Tao, K., Lu, X., Ma, J., Mao, Z. ... Wang, G. (2015). Vasoactive intestinal peptide induces CD14+HLA-DR‑/low myeloid-derived suppressor cells in gastric cancer. Molecular Medicine Reports, 12, 760-768. https://doi.org/10.3892/mmr.2015.3374
MLA
Li, G., Wu, K., Tao, K., Lu, X., Ma, J., Mao, Z., Li, H., Shi, L., Li, J., Niu, Y., Xiang, F., Wang, G."Vasoactive intestinal peptide induces CD14+HLA-DR‑/low myeloid-derived suppressor cells in gastric cancer". Molecular Medicine Reports 12.1 (2015): 760-768.
Chicago
Li, G., Wu, K., Tao, K., Lu, X., Ma, J., Mao, Z., Li, H., Shi, L., Li, J., Niu, Y., Xiang, F., Wang, G."Vasoactive intestinal peptide induces CD14+HLA-DR‑/low myeloid-derived suppressor cells in gastric cancer". Molecular Medicine Reports 12, no. 1 (2015): 760-768. https://doi.org/10.3892/mmr.2015.3374
Copy and paste a formatted citation
x
Spandidos Publications style
Li G, Wu K, Tao K, Lu X, Ma J, Mao Z, Li H, Shi L, Li J, Niu Y, Niu Y, et al: Vasoactive intestinal peptide induces CD14+HLA-DR‑/low myeloid-derived suppressor cells in gastric cancer. Mol Med Rep 12: 760-768, 2015.
APA
Li, G., Wu, K., Tao, K., Lu, X., Ma, J., Mao, Z. ... Wang, G. (2015). Vasoactive intestinal peptide induces CD14+HLA-DR‑/low myeloid-derived suppressor cells in gastric cancer. Molecular Medicine Reports, 12, 760-768. https://doi.org/10.3892/mmr.2015.3374
MLA
Li, G., Wu, K., Tao, K., Lu, X., Ma, J., Mao, Z., Li, H., Shi, L., Li, J., Niu, Y., Xiang, F., Wang, G."Vasoactive intestinal peptide induces CD14+HLA-DR‑/low myeloid-derived suppressor cells in gastric cancer". Molecular Medicine Reports 12.1 (2015): 760-768.
Chicago
Li, G., Wu, K., Tao, K., Lu, X., Ma, J., Mao, Z., Li, H., Shi, L., Li, J., Niu, Y., Xiang, F., Wang, G."Vasoactive intestinal peptide induces CD14+HLA-DR‑/low myeloid-derived suppressor cells in gastric cancer". Molecular Medicine Reports 12, no. 1 (2015): 760-768. https://doi.org/10.3892/mmr.2015.3374
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team