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Article

Synergistic hepatotoxicity by cadmium and chlorpyrifos: Disordered hepatic lipid homeostasis

  • Authors:
    • Wei He
    • Wenli Guo
    • Yi Qian
    • Shuping Zhang
    • Difeng Ren
    • Sijin Liu
  • View Affiliations / Copyright

    Affiliations: Beijing Key Laboratory of Forestry Food Processing and Safety, College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, P.R. China, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco‑Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P.R. China
  • Pages: 303-308
    |
    Published online on: February 24, 2015
       https://doi.org/10.3892/mmr.2015.3381
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Abstract

Due to its extensive application, chlorpyrifos (CPF) has contaminated a diverse range of environmental substrates, fruits and vegetables. A number of studies have suggested that CPF may incur adverse effects on human health, including neurotoxicity, hepatotoxicity and endocrine disruption. Additionally, cadmium (Cd) is one of the most prevalent environmental heavy metals, as a result of considerable use in a wide spectrum of industrial fields. Exposure to Cd can cause several lesions in various organs, including the liver, kidneys and lungs. CPF and Cd often co‑exist in the environment, food and crops, however, their joint exposure and potential synergistic toxicity are largely neglected and unrecognized. Our previous study characterized an interaction between CPF and Cd, which may occur via bonding between Cd2+ and the nitrogen atom in the pyridine ring of CPF, or the chelation between one Cd2+ and two CPF molecules. Our previous study also identified increased hepatotoxicity induced by CPF and Cd together compared with the individual compounds. In the present study, the effects of the concomitant exposure of CPF and Cd on lipid metabolism in hepatocytes was investigated. The results demonstrated an accumulation of lipids in hepatocytes, induced by the CPF and Cd complex, which was fundamentally distinct from its parental chemicals. Notably, the molecular mechanism by which the CPF‑Cd complex significantly induced hepatic lipogenesis was revealed, elevating the concentrations of sterol regulatory element‑binding protein‑1 and fatty acid synthase. These findings pave the way for future studies in recognizing synergistic biological effects between pollutants.
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Copy and paste a formatted citation
Spandidos Publications style
He W, Guo W, Qian Y, Zhang S, Ren D and Liu S: Synergistic hepatotoxicity by cadmium and chlorpyrifos: Disordered hepatic lipid homeostasis. Mol Med Rep 12: 303-308, 2015.
APA
He, W., Guo, W., Qian, Y., Zhang, S., Ren, D., & Liu, S. (2015). Synergistic hepatotoxicity by cadmium and chlorpyrifos: Disordered hepatic lipid homeostasis. Molecular Medicine Reports, 12, 303-308. https://doi.org/10.3892/mmr.2015.3381
MLA
He, W., Guo, W., Qian, Y., Zhang, S., Ren, D., Liu, S."Synergistic hepatotoxicity by cadmium and chlorpyrifos: Disordered hepatic lipid homeostasis". Molecular Medicine Reports 12.1 (2015): 303-308.
Chicago
He, W., Guo, W., Qian, Y., Zhang, S., Ren, D., Liu, S."Synergistic hepatotoxicity by cadmium and chlorpyrifos: Disordered hepatic lipid homeostasis". Molecular Medicine Reports 12, no. 1 (2015): 303-308. https://doi.org/10.3892/mmr.2015.3381
Copy and paste a formatted citation
x
Spandidos Publications style
He W, Guo W, Qian Y, Zhang S, Ren D and Liu S: Synergistic hepatotoxicity by cadmium and chlorpyrifos: Disordered hepatic lipid homeostasis. Mol Med Rep 12: 303-308, 2015.
APA
He, W., Guo, W., Qian, Y., Zhang, S., Ren, D., & Liu, S. (2015). Synergistic hepatotoxicity by cadmium and chlorpyrifos: Disordered hepatic lipid homeostasis. Molecular Medicine Reports, 12, 303-308. https://doi.org/10.3892/mmr.2015.3381
MLA
He, W., Guo, W., Qian, Y., Zhang, S., Ren, D., Liu, S."Synergistic hepatotoxicity by cadmium and chlorpyrifos: Disordered hepatic lipid homeostasis". Molecular Medicine Reports 12.1 (2015): 303-308.
Chicago
He, W., Guo, W., Qian, Y., Zhang, S., Ren, D., Liu, S."Synergistic hepatotoxicity by cadmium and chlorpyrifos: Disordered hepatic lipid homeostasis". Molecular Medicine Reports 12, no. 1 (2015): 303-308. https://doi.org/10.3892/mmr.2015.3381
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