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Article

Ligustrazine attenuates the platelet‑derived growth factor-BB-induced proliferation and migration of vascular smooth muscle cells by interrupting extracellular signal-regulated kinase and P38 mitogen-activated protein kinase pathways

  • Authors:
    • Lifei Yu
    • Xiaojing Huang
    • Kai Huang
    • Chun Gui
    • Qiaojuan Huang
    • Bin Wei
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Western Hospital, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
  • Pages: 705-711
    |
    Published online on: February 24, 2015
       https://doi.org/10.3892/mmr.2015.3383
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Abstract

The abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) leads to intimal thickening of the aorta and is, therefore, important in the development of arteriosclerosis. As a result, the use of antiproliferative and antimigratory agents for VSMCs offers promise for the treatment of vascular disorders. Although several studies have demonstrated that ligustrazine may be used to treat heart and blood vessel diseases, the detailed mechanism underlying its actions remain to be elucidated. In the present study, the inhibitory effect of ligustrazine on platelet‑derived growth factor (PDGF)‑BB‑stimulated VSMC proliferation and migration, and the underlying mechanisms were investigated. The findings demonstrated that ligustrazine significantly inhibited PDGF‑BB‑stimulated VSMC proliferation. VSMCs dedifferentiated into a proliferative phenotype under PDGF‑BB stimulation, which was effectively reversed by the administration of ligustrazine. In addition, ligustrazine also downregulated the production of nitric oxide and cyclic guanine monophosphate, induced by PDGF‑BB. Additionally, ligustrazine significantly inhibited PDGF‑BB‑stimulated VSMC migration. Mechanistic investigation indicated that the upregulation of cell cycle‑associated proteins and the activation of the extracellular signal‑regulated kinase (ERK) and P38 mitogen‑activated protein kinase (MAPK) signaling induced by PDGF‑BB was suppressed by the administration of ligustrazine. In conclusion, the present study, demonstrated for the first time, to the best of our knowledge, that ligustrazine downregulated PDGF‑BB‑induced VSMC proliferation and migration partly, at least, through inhibiting the activation of the ERK and P38 MAPK signaling.
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Copy and paste a formatted citation
Spandidos Publications style
Yu L, Huang X, Huang K, Gui C, Huang Q and Wei B: Ligustrazine attenuates the platelet‑derived growth factor-BB-induced proliferation and migration of vascular smooth muscle cells by interrupting extracellular signal-regulated kinase and P38 mitogen-activated protein kinase pathways. Mol Med Rep 12: 705-711, 2015.
APA
Yu, L., Huang, X., Huang, K., Gui, C., Huang, Q., & Wei, B. (2015). Ligustrazine attenuates the platelet‑derived growth factor-BB-induced proliferation and migration of vascular smooth muscle cells by interrupting extracellular signal-regulated kinase and P38 mitogen-activated protein kinase pathways. Molecular Medicine Reports, 12, 705-711. https://doi.org/10.3892/mmr.2015.3383
MLA
Yu, L., Huang, X., Huang, K., Gui, C., Huang, Q., Wei, B."Ligustrazine attenuates the platelet‑derived growth factor-BB-induced proliferation and migration of vascular smooth muscle cells by interrupting extracellular signal-regulated kinase and P38 mitogen-activated protein kinase pathways". Molecular Medicine Reports 12.1 (2015): 705-711.
Chicago
Yu, L., Huang, X., Huang, K., Gui, C., Huang, Q., Wei, B."Ligustrazine attenuates the platelet‑derived growth factor-BB-induced proliferation and migration of vascular smooth muscle cells by interrupting extracellular signal-regulated kinase and P38 mitogen-activated protein kinase pathways". Molecular Medicine Reports 12, no. 1 (2015): 705-711. https://doi.org/10.3892/mmr.2015.3383
Copy and paste a formatted citation
x
Spandidos Publications style
Yu L, Huang X, Huang K, Gui C, Huang Q and Wei B: Ligustrazine attenuates the platelet‑derived growth factor-BB-induced proliferation and migration of vascular smooth muscle cells by interrupting extracellular signal-regulated kinase and P38 mitogen-activated protein kinase pathways. Mol Med Rep 12: 705-711, 2015.
APA
Yu, L., Huang, X., Huang, K., Gui, C., Huang, Q., & Wei, B. (2015). Ligustrazine attenuates the platelet‑derived growth factor-BB-induced proliferation and migration of vascular smooth muscle cells by interrupting extracellular signal-regulated kinase and P38 mitogen-activated protein kinase pathways. Molecular Medicine Reports, 12, 705-711. https://doi.org/10.3892/mmr.2015.3383
MLA
Yu, L., Huang, X., Huang, K., Gui, C., Huang, Q., Wei, B."Ligustrazine attenuates the platelet‑derived growth factor-BB-induced proliferation and migration of vascular smooth muscle cells by interrupting extracellular signal-regulated kinase and P38 mitogen-activated protein kinase pathways". Molecular Medicine Reports 12.1 (2015): 705-711.
Chicago
Yu, L., Huang, X., Huang, K., Gui, C., Huang, Q., Wei, B."Ligustrazine attenuates the platelet‑derived growth factor-BB-induced proliferation and migration of vascular smooth muscle cells by interrupting extracellular signal-regulated kinase and P38 mitogen-activated protein kinase pathways". Molecular Medicine Reports 12, no. 1 (2015): 705-711. https://doi.org/10.3892/mmr.2015.3383
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