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N-acetylcysteine treatment following spinal cord trauma reduces neural tissue damage and improves locomotor function in mice

  • Authors:
    • Jian Guo
    • Yiqiao Li
    • Zhong Chen
    • Zhennian He
    • Bin Zhang
    • Yonghuan Li
    • Jianghua Hu
    • Mingyuan Han
    • Yuanlin Xu
    • Yongfu Li
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, Ningbo Beilun People Hospital, Ningbo, Zhejiang 315800, P.R. China, Central Laboratory, Ningbo Beilun People Hospital, Ningbo, Zhejiang 315800, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 37-44
    |
    Published online on: February 26, 2015
       https://doi.org/10.3892/mmr.2015.3390
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Abstract

Following spinal cord trauma, mitochondrial dysfunction associated with increased oxidative stress is a critical event leading to leukocyte inflammatory responses, neuronal cell death and demyelination, contributing to permanent locomotor and neurological disability. The present study demonstrated that the mitochondrial enhancer N‑acetylcysteine (NAC) may restore redox balance via enhancement of mitochondrial respiratory activity following traumatic spinal cord injury (SCI). In addition, NAC ameliorates oxidative stress‑induced neuronal loss, demyelination, leukocyte infiltration and inflammatory mediator expression and improves long‑term locomotor function. Furthermore, neuronal survival and neurological recovery are significantly correlated with increased mitochondrial bioenergetics in SCI following treatment with NAC. Therefore, NAC may represent a potential therapeutic agent for preserving mitochondrial dynamics and integrity following traumatic SCI.
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Copy and paste a formatted citation
Spandidos Publications style
Guo J, Li Y, Chen Z, He Z, Zhang B, Li Y, Hu J, Han M, Xu Y, Li Y, Li Y, et al: N-acetylcysteine treatment following spinal cord trauma reduces neural tissue damage and improves locomotor function in mice. Mol Med Rep 12: 37-44, 2015.
APA
Guo, J., Li, Y., Chen, Z., He, Z., Zhang, B., Li, Y. ... Li, Y. (2015). N-acetylcysteine treatment following spinal cord trauma reduces neural tissue damage and improves locomotor function in mice. Molecular Medicine Reports, 12, 37-44. https://doi.org/10.3892/mmr.2015.3390
MLA
Guo, J., Li, Y., Chen, Z., He, Z., Zhang, B., Li, Y., Hu, J., Han, M., Xu, Y., Li, Y."N-acetylcysteine treatment following spinal cord trauma reduces neural tissue damage and improves locomotor function in mice". Molecular Medicine Reports 12.1 (2015): 37-44.
Chicago
Guo, J., Li, Y., Chen, Z., He, Z., Zhang, B., Li, Y., Hu, J., Han, M., Xu, Y., Li, Y."N-acetylcysteine treatment following spinal cord trauma reduces neural tissue damage and improves locomotor function in mice". Molecular Medicine Reports 12, no. 1 (2015): 37-44. https://doi.org/10.3892/mmr.2015.3390
Copy and paste a formatted citation
x
Spandidos Publications style
Guo J, Li Y, Chen Z, He Z, Zhang B, Li Y, Hu J, Han M, Xu Y, Li Y, Li Y, et al: N-acetylcysteine treatment following spinal cord trauma reduces neural tissue damage and improves locomotor function in mice. Mol Med Rep 12: 37-44, 2015.
APA
Guo, J., Li, Y., Chen, Z., He, Z., Zhang, B., Li, Y. ... Li, Y. (2015). N-acetylcysteine treatment following spinal cord trauma reduces neural tissue damage and improves locomotor function in mice. Molecular Medicine Reports, 12, 37-44. https://doi.org/10.3892/mmr.2015.3390
MLA
Guo, J., Li, Y., Chen, Z., He, Z., Zhang, B., Li, Y., Hu, J., Han, M., Xu, Y., Li, Y."N-acetylcysteine treatment following spinal cord trauma reduces neural tissue damage and improves locomotor function in mice". Molecular Medicine Reports 12.1 (2015): 37-44.
Chicago
Guo, J., Li, Y., Chen, Z., He, Z., Zhang, B., Li, Y., Hu, J., Han, M., Xu, Y., Li, Y."N-acetylcysteine treatment following spinal cord trauma reduces neural tissue damage and improves locomotor function in mice". Molecular Medicine Reports 12, no. 1 (2015): 37-44. https://doi.org/10.3892/mmr.2015.3390
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