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Article

Combination of cytokinin and auxin induces apoptosis, cell cycle progression arrest and blockage of the Akt pathway in HeLa cells

  • Authors:
    • Liwei Zhao
    • Peng Liu
    • Guangqin Guo
    • Li Wang
  • View Affiliations / Copyright

    Affiliations: Department of Cell Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, P.R. China
  • Pages: 719-727
    |
    Published online on: March 4, 2015
       https://doi.org/10.3892/mmr.2015.3420
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Abstract

Plant cytokinins and auxins have recently been proposed as novel cancer therapies, which proceed via different mechanisms; however, their combined use has not been investigated. To the best of our knowledge, the present study was the first to show that the cytokinin ortho‑methoxytopolin‑riboside (MeoTR) strongly inhibited the proliferation of HeLa cells, the effect of which was synergistically enhanced by auxin indole‑3‑acetic acid (IAA), while IAA demonstrated to have no cytotoxic effects on cells. MeoTR was found to activate intrinsic and extrinsic caspase‑dependent pathways, and IAA potentiated this activation. In addition, these effects were blocked by Z‑Val‑Ala‑Asp‑fluoromethylketone (Z‑VAD‑FMK), a pan‑specific‑caspase‑inhibitor. IAA increased the MeoTR‑ induced inhibition of B cell lymphoma 2 (Bcl‑2) and survivin, whereas IAA‑only decreased Bcl‑2 expression. MeoTR downregulated phosphorylated (p)‑pyruvate dehydrogenase kinase 1, p‑Akt and p‑glycogen synthase kinase 3β, the effect of which was more potent in combination with IAA, despite the weak effect of IAA alone. LY294002, an Akt‑inhibitor, was able to increase the inhibition of p‑Akt through MeoTR and combination treatment. IAA and MeoTR increased the proportion of cells in S phase independently. However, the combination treatment induced a further increase. In addition, IAA and MeoTR treatment downregulated protein levels of cyclin A, cyclin‑dependent kinase 2 (CDK2) and p‑CDK2, and upregulated protein levels of p21 and p27. Furthermore, the combination treatment enhanced these effects, indicating that IAA potentiated the inhibitory effect of MeoTR on HeLa cells via cell cycle progression arrest and accumulation in S phase, coupled with the negative regulation of Bcl‑2. In conclusion, the results of the present study suggested that treatment with these two phytohormones in combination, may offer a novel therapeutic strategy for the treatment of malignant cervical cancer.
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1 

Skoog F and Miller CO: Chemical regulation of growth and organ formation in plant tissues cultured in vitro. Symp Soc Exp Biol. 11:118–130. 1957.PubMed/NCBI

2 

Dolezal K, Popa I, Hauserova E, et al: Preparation, biological activity and endogenous occurrence of N6-benzyladenosines. Bioorg Med Chem. 15:3737–3747. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Strnad M: The aromatic cytokinins. Physiol Plantarum. 101:674–688. 1997. View Article : Google Scholar

4 

Barciszewski J, Massino F and Clark BF: Kinetin-a multiactive molecule. Int J Biol Macromol. 40:182–192. 2007. View Article : Google Scholar

5 

Horgan R, Hewett EW, Horgan JM, Purse J and Wareing PF: A new cytokinin from Populus × robusta. Phytochemistry. 14:1005–1008. 1975. View Article : Google Scholar

6 

Jones LH, Martinkova H, Strnad M and Hanke DE: Occurrence of aromatic cytokinins in oil palm (Elaeis guineensis Jacq). J Plant Growth Regul. 15:39–49. 1996. View Article : Google Scholar

7 

Ördög V, Stirk WA, Van Staden J, Novák O and Strnad M: Endogenous cytokinins in three genera of microalgae from the chlorophyta1. J Phycol. 40:88–95. 2004. View Article : Google Scholar

8 

Cheong J, Goh D, Yong JW, Tan SN and Ong ES: Inhibitory effect of kinetin riboside in human heptamoa, HepG2. Mol Biosyst. 5:91–98. 2009. View Article : Google Scholar

9 

Ishii Y, Hori Y, Sakai S and Honma Y: Control of differentiation and apoptosis of human myeloid leukemia cells by cytokinins and cytokinin nucleosides, plant redifferentiation-inducing hormones. Cell Growth Differ. 13:19–26. 2002.PubMed/NCBI

10 

Ishii Y, Sakai S and Honma Y: Cytokinin-induced differentiation of human myeloid leukemia HL-60 cells is associated with the formation of nucleotides, but not with incorporation into DNA or RNA. Biochim Biophys Acta. 1643:11–24. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Wang L, Sun C, Wang ZH and Guo GQ: Mechanism of apoptotosis induced by orthotopolin riboside in human hepatoma cell line SMMC-7721. Food Chem Toxicol. 50:1962–1968. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Castiglioni S, Casati S, Ottria R, Ciuffreda P and Maier JA: N6-isopentenyladenosine and its analogue N6-benzyladenosine induce cell cycle arrest and apoptosis in bladder carcinoma T24 cells. Anticancer Agents Med Chem. 13:672–678. 2013. View Article : Google Scholar

13 

Goldsmith MH: Cellular signaling: new insights into the action of the plant growth hormone auxin. Proc Natl Acad Sci USA. 90:11442–11445. 1993. View Article : Google Scholar : PubMed/NCBI

14 

Kim DS, Jeon SE and Park KC: Oxidation of indole-3-acetic acid by horseradish peroxidase induces apoptosis in G361 human melanoma cells. Cell Signal. 16:81–88. 2004. View Article : Google Scholar

15 

Kim DS, Kim SY, Jeong YM, et al: Indole-3-acetic acid/horseradish peroxidase-induced apoptosis involves cell surface CD95 (Fas/APO-1) expression. Biol Pharm Bull. 29:1625–1629. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Folkes LK and Wardman P: Enhancing the efficacy of photodynamic cancer therapy by radicals from plant auxin (indole-3-acetic acid). Cancer Res. 63:776–779. 2003.PubMed/NCBI

17 

Kim DS, Kim SY, Jeong YM, et al: Light-activated indole-3-acetic acid induces apoptosis in g361 human melanoma cells. Biol Pharm Bull. 29:2404–2409. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Kim SY, Ryu JS, Li H, et al: UVB-activated indole-3-acetic acid induces apoptosis of pc-3 prostate cancer cells. Anticancer Res. 30:4607–4612. 2010.PubMed/NCBI

19 

Wang D, Wang Z, Tian B, Li X, Li S and Tian Y: Two hour exposure to sodium butyrate sensitizes bladder cancer to anticancer drugs. Int J Urol. 15:435–441. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Vander Heiden MG, Chandel NS, Williamson EK, Schumacker PT and Thompson CB: Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell. 91:627–637. 1997. View Article : Google Scholar : PubMed/NCBI

21 

Alnemri ES, Livingston DJ, Nicholson DW, et al: Human ICE/CED-3 protease nomenclature. Cell. 87:1711996. View Article : Google Scholar : PubMed/NCBI

22 

Hengartner MO: The biochemistry of apoptosis. Nature. 407:770–776. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Liu TZ, Cheng JT, Yiin SJ, et al: Isoobtusilactone A induces both caspase-dependent and -independent apoptosis in Hep G2 cells. Food Chem Toxicol. 46:321–327. 2008. View Article : Google Scholar

24 

Pap M and Cooper GM: Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J Biol Chem. 273:19929–19932. 1998. View Article : Google Scholar : PubMed/NCBI

25 

Pap M and Cooper GM: Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta signaling pathway. Mol Cell Biol. 22:578–586. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Lin CF, Chen CL, Chiang CW, Jan MS, Huang WC and Lin YS: GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis. J Cell Sci. 120:2935–2943. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Bondar VM, Sweeney-Gotsch B, Andreeff M, Mills GB and McConkey DJ: Inhibition of the phosphatidylinositol 3′-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo. Mol Cancer Ther. 1:989–997. 2002.PubMed/NCBI

28 

Zheng WH and Quirion R: Insulin-like growth factor-1 (IGF-1) induces the activation/phosphorylation of Akt kinase and cAMP response element-binding protein (CREB) by activating different signaling pathways in PC12 cells. BMC Neurosci. 7:512006. View Article : Google Scholar : PubMed/NCBI

29 

Chen T, Stephens PA, Middleton FK and Curtin NJ: Targeting the S and G2 checkpoint to treat cancer. Drug Discov Today. 17:194–202. 2012. View Article : Google Scholar

30 

Vermeulen K, Van Bockstaele DR and Berneman ZN: The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif. 36:131–149. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Yoon MK, Mitrea DM, Ou L and Kriwacki RW: Cell cycle regulation by the intrinsically disordered proteins p21 and p27. Biochem Soc Trans. 40:981–988. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Sarraf CE and Bowen ID: Proportions of mitotic and apoptotic cells in a range of untreated experimental tumours. Cell and tissue kinetics. 21:45–49. 1988.PubMed/NCBI

33 

Wyllie AH: Apoptosis (the 1992 Frank Rose Memorial Lecture). Br J Cancer. 67:205–208. 1993. View Article : Google Scholar : PubMed/NCBI

34 

Green DR: Apoptotic pathways: paper wraps stone blunts scissors. Cell. 102:1–4. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Scoltock AB and Cidlowski JA: Activation of intrinsic and extrinsic pathways in apoptotic signaling during UV-C-induced death of Jurkat cells: the role of caspase inhibition. Exp Cell Res. 297:212–223. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Li P, Nijhawan D, Budihardjo I, et al: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 91:479–489. 1997. View Article : Google Scholar : PubMed/NCBI

37 

Boatright KM, Renatus M, Scott FL, et al: A unified model for apical caspase activation. Mol Cell. 11:529–541. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Kruyt FA and Schuringa JJ: Apoptosis and cancer stem cells: Implications for apoptosis targeted therapy. Biochem Pharmacol. 80:423–430. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Budihardjo I, Oliver H, Lutter M, Luo X and Wang X: Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol. 15:269–290. 1999. View Article : Google Scholar : PubMed/NCBI

40 

Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL and Korsmeyer SJ: Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell. 75:241–251. 1993. View Article : Google Scholar : PubMed/NCBI

41 

Kim E, Matsuse M, Saenko V, et al: Imatinib enhances docetaxel-induced apoptosis through inhibition of nuclear factor-kappaB activation in anaplastic thyroid carcinoma cells. Thyroid. 22:717–724. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Lee R and Collins T: Nuclear factor-kappaB and cell survival: IAPs call for support. Circ Res. 88:262–264. 2001. View Article : Google Scholar : PubMed/NCBI

43 

Brazil DP and Hemmings BA: Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem Sci. 26:657–664. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Lawlor MA and Alessi DR: PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci. 114:2903–2910. 2001.PubMed/NCBI

45 

Martelli AM, Tazzari PL, Tabellini G, et al: A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid and ionizing radiation of human leukemia cells. Leukemia. 17:1794–1805. 2003. View Article : Google Scholar : PubMed/NCBI

46 

Kim SY, Ryu JS, Li H, et al: UVB-activated indole-3-acetic acid induces apoptosis of PC-3 prostate cancer cells. Anticancer Res. 30:4607–4612. 2010.PubMed/NCBI

47 

Folkes LK and Wardman P: Oxidative activation of indole-3-acetic acids to cytotoxic species-a potential new role for plant auxins in cancer therapy. Biochem Pharmacol. 61:129–136. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao L, Liu P, Guo G and Wang L: Combination of cytokinin and auxin induces apoptosis, cell cycle progression arrest and blockage of the Akt pathway in HeLa cells. Mol Med Rep 12: 719-727, 2015.
APA
Zhao, L., Liu, P., Guo, G., & Wang, L. (2015). Combination of cytokinin and auxin induces apoptosis, cell cycle progression arrest and blockage of the Akt pathway in HeLa cells. Molecular Medicine Reports, 12, 719-727. https://doi.org/10.3892/mmr.2015.3420
MLA
Zhao, L., Liu, P., Guo, G., Wang, L."Combination of cytokinin and auxin induces apoptosis, cell cycle progression arrest and blockage of the Akt pathway in HeLa cells". Molecular Medicine Reports 12.1 (2015): 719-727.
Chicago
Zhao, L., Liu, P., Guo, G., Wang, L."Combination of cytokinin and auxin induces apoptosis, cell cycle progression arrest and blockage of the Akt pathway in HeLa cells". Molecular Medicine Reports 12, no. 1 (2015): 719-727. https://doi.org/10.3892/mmr.2015.3420
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao L, Liu P, Guo G and Wang L: Combination of cytokinin and auxin induces apoptosis, cell cycle progression arrest and blockage of the Akt pathway in HeLa cells. Mol Med Rep 12: 719-727, 2015.
APA
Zhao, L., Liu, P., Guo, G., & Wang, L. (2015). Combination of cytokinin and auxin induces apoptosis, cell cycle progression arrest and blockage of the Akt pathway in HeLa cells. Molecular Medicine Reports, 12, 719-727. https://doi.org/10.3892/mmr.2015.3420
MLA
Zhao, L., Liu, P., Guo, G., Wang, L."Combination of cytokinin and auxin induces apoptosis, cell cycle progression arrest and blockage of the Akt pathway in HeLa cells". Molecular Medicine Reports 12.1 (2015): 719-727.
Chicago
Zhao, L., Liu, P., Guo, G., Wang, L."Combination of cytokinin and auxin induces apoptosis, cell cycle progression arrest and blockage of the Akt pathway in HeLa cells". Molecular Medicine Reports 12, no. 1 (2015): 719-727. https://doi.org/10.3892/mmr.2015.3420
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