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Article

Estimation of the environmental effect of natural volatile organic compounds from Chamaecyparis obtusa and their effect on atopic dermatitis-like skin lesions in mice

  • Authors:
    • Hyun Yang
    • Changhwan Ahn
    • In‑Gyu Choi
    • Won‑Sil Choi
    • Mi‑Jin Park
    • Sung‑Suk Lee
    • Don‑Ha Choi
    • Eui‑Bae Jeung
  • View Affiliations / Copyright

    Affiliations: Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361‑763, Republic of Korea, Department of Forest Sciences, College of Agriculture and Life Sciences, Seoul National University, Seoul 151‑921, Republic of Korea, Chromatography Laboratory, National Instrumentation Center for Environmental Management, Seoul National University, Seoul 151‑921, Republic of Korea, Department of Forest Products, Division of Wood Chemistry and Microbiology, Korea Forest Research Institute, Seoul 130‑712, Republic of Korea
  • Pages: 345-350
    |
    Published online on: March 5, 2015
       https://doi.org/10.3892/mmr.2015.3431
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Abstract

Aromatherapy has been suggested as an alternative therapeutic method for the treatment of atopic dermatitis (AD), eczema and other skin diseases. In the current study, the anti‑atopic properties of the volatile organic compounds of Chamaecyparis obtusa (VOCCo) were examined to determine whether they are amenable for use as a pharmaceutical candidate. The alterations in histological features, serum IgE levels and mast cell infiltration following exposure to VOCCo were determined in a 2,4-dinitrochlorobenzene (DNCB)-induced AD-like mouse model. The results of these experiments demonstrated that VOCCo inhibited the development of AD‑like skin lesions by reducing the serum IgE level and mast cell infiltration into the dermal and subcutaneous layers. This was supported by screening of immune cytokine mRNAs, including interleukin (IL)‑1β and IL‑6 from the skin of DNCB‑treated mice. The expression of IL‑1β and IL‑6 in the skin lesions of mice was dose-dependently inhibited by treatment with VOCCo. Furthermore, treatment with VOCCo resulted in the recovery of histopathological features in AD-like skin lesions. These results suggest that VOCCo may have therapeutic and preventive effects for the development of AD.
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Copy and paste a formatted citation
Spandidos Publications style
Yang H, Ahn C, Choi IG, Choi WS, Park MJ, Lee SS, Choi DH and Jeung EB: Estimation of the environmental effect of natural volatile organic compounds from Chamaecyparis obtusa and their effect on atopic dermatitis-like skin lesions in mice. Mol Med Rep 12: 345-350, 2015.
APA
Yang, H., Ahn, C., Choi, I., Choi, W., Park, M., Lee, S. ... Jeung, E. (2015). Estimation of the environmental effect of natural volatile organic compounds from Chamaecyparis obtusa and their effect on atopic dermatitis-like skin lesions in mice. Molecular Medicine Reports, 12, 345-350. https://doi.org/10.3892/mmr.2015.3431
MLA
Yang, H., Ahn, C., Choi, I., Choi, W., Park, M., Lee, S., Choi, D., Jeung, E."Estimation of the environmental effect of natural volatile organic compounds from Chamaecyparis obtusa and their effect on atopic dermatitis-like skin lesions in mice". Molecular Medicine Reports 12.1 (2015): 345-350.
Chicago
Yang, H., Ahn, C., Choi, I., Choi, W., Park, M., Lee, S., Choi, D., Jeung, E."Estimation of the environmental effect of natural volatile organic compounds from Chamaecyparis obtusa and their effect on atopic dermatitis-like skin lesions in mice". Molecular Medicine Reports 12, no. 1 (2015): 345-350. https://doi.org/10.3892/mmr.2015.3431
Copy and paste a formatted citation
x
Spandidos Publications style
Yang H, Ahn C, Choi IG, Choi WS, Park MJ, Lee SS, Choi DH and Jeung EB: Estimation of the environmental effect of natural volatile organic compounds from Chamaecyparis obtusa and their effect on atopic dermatitis-like skin lesions in mice. Mol Med Rep 12: 345-350, 2015.
APA
Yang, H., Ahn, C., Choi, I., Choi, W., Park, M., Lee, S. ... Jeung, E. (2015). Estimation of the environmental effect of natural volatile organic compounds from Chamaecyparis obtusa and their effect on atopic dermatitis-like skin lesions in mice. Molecular Medicine Reports, 12, 345-350. https://doi.org/10.3892/mmr.2015.3431
MLA
Yang, H., Ahn, C., Choi, I., Choi, W., Park, M., Lee, S., Choi, D., Jeung, E."Estimation of the environmental effect of natural volatile organic compounds from Chamaecyparis obtusa and their effect on atopic dermatitis-like skin lesions in mice". Molecular Medicine Reports 12.1 (2015): 345-350.
Chicago
Yang, H., Ahn, C., Choi, I., Choi, W., Park, M., Lee, S., Choi, D., Jeung, E."Estimation of the environmental effect of natural volatile organic compounds from Chamaecyparis obtusa and their effect on atopic dermatitis-like skin lesions in mice". Molecular Medicine Reports 12, no. 1 (2015): 345-350. https://doi.org/10.3892/mmr.2015.3431
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