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In‑depth mapping of human testicular and epididymal proteins and their functional association with spermatozoa

  • Authors:
    • Xuexia Liu
    • Fujun Liu
  • View Affiliations / Copyright

    Affiliations: Central Laboratory, Yantai Yu Huang Ding Hospital, Qingdao University, Yantai, Shandong 264000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 173-179
    |
    Published online on: March 5, 2015
       https://doi.org/10.3892/mmr.2015.3435
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Abstract

The mammalian testis and epididymis are responsible for spermatozoa production and maturation, which contributes to male fertility. Predominantly expressed proteins in the testis and epididymis were suggested to be involved in the key functions or pathways in spermatogenesis and sperm maturation. To further investigate these proteins and their associations with sperm, large protein profiles of human testis and epididymis were mapped. Predominantly‑expressed testicular (173) and epididymal (244) secreted proteins were further screened and functionally characterized. Differential expression levels of solute carrier family 2 (facilitated glucose transporter), member 3, solute carrier family 25 (carnitine/acylcarnitine translocase), member 20, WAP‑type four‑disulfide core domain protein 8 and prostate and testis expressed 1 were validated using western blot and immunohistochemical analyses. The results may provide novel insight into the understanding of testicular and epididymal physiology and function, and facilitate sperm maturation research.
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Copy and paste a formatted citation
Spandidos Publications style
Liu X and Liu F: In‑depth mapping of human testicular and epididymal proteins and their functional association with spermatozoa. Mol Med Rep 12: 173-179, 2015.
APA
Liu, X., & Liu, F. (2015). In‑depth mapping of human testicular and epididymal proteins and their functional association with spermatozoa. Molecular Medicine Reports, 12, 173-179. https://doi.org/10.3892/mmr.2015.3435
MLA
Liu, X., Liu, F."In‑depth mapping of human testicular and epididymal proteins and their functional association with spermatozoa". Molecular Medicine Reports 12.1 (2015): 173-179.
Chicago
Liu, X., Liu, F."In‑depth mapping of human testicular and epididymal proteins and their functional association with spermatozoa". Molecular Medicine Reports 12, no. 1 (2015): 173-179. https://doi.org/10.3892/mmr.2015.3435
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X and Liu F: In‑depth mapping of human testicular and epididymal proteins and their functional association with spermatozoa. Mol Med Rep 12: 173-179, 2015.
APA
Liu, X., & Liu, F. (2015). In‑depth mapping of human testicular and epididymal proteins and their functional association with spermatozoa. Molecular Medicine Reports, 12, 173-179. https://doi.org/10.3892/mmr.2015.3435
MLA
Liu, X., Liu, F."In‑depth mapping of human testicular and epididymal proteins and their functional association with spermatozoa". Molecular Medicine Reports 12.1 (2015): 173-179.
Chicago
Liu, X., Liu, F."In‑depth mapping of human testicular and epididymal proteins and their functional association with spermatozoa". Molecular Medicine Reports 12, no. 1 (2015): 173-179. https://doi.org/10.3892/mmr.2015.3435
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