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Review

Mycobacteriophages: An important tool for the diagnosis of Mycobacterium tuberculosis (Review)

  • Authors:
    • Xiaoyan Fu
    • Mingxing Ding
    • Ning Zhang
    • Jicheng Li
  • View Affiliations / Copyright

    Affiliations: Department of Medical Sciences, Jinhua College of Profession and Technology, Jinhua, Zhejiang 321007, P.R. China, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, P.R. China
  • Pages: 13-19
    |
    Published online on: March 5, 2015
       https://doi.org/10.3892/mmr.2015.3440
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Abstract

The prevention and control of tuberculosis (TB) on a global scale has become increasingly important with the emergence of multidrug‑resistant TB. Mycobacterium tuberculosis phages have been identified as an important investigative tool. Phage genomes exhibit a significant level of diversity and mosaic genome architecture, however, they are simple structures, which are amenable to genetic manipulation. Based on these characteristics, the phages may be used to construct a shuttle plasmid, which is an indispensable tool in the investigation of TB. Furthermore, they may be used for rapid diagnosis and assessing drug susceptibility of TB, including phage amplified assessment and reporter phage technology. With an improved understanding of mycobacteriophages, further clarification of the pathogenesis of TB, and of the implications for its diagnosis and therapy, may be elucidated.
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1 

Weir RE, Gorak-Stolinska P, Floyd S, et al: Persistence of the immune response induced by BCG vaccination. BMC Infect Dis. 8:1–9. 2008. View Article : Google Scholar

2 

Gardner GM and Weiser RS: A bacteriophage for Mycobacterium smegmatis. Proc Soc Exp Biol Med. 66:2051947. View Article : Google Scholar : PubMed/NCBI

3 

Mycobacteriophage database. http://www.phagesdb.org/. Accessed 16 May, 2014.

4 

Hatfull GF and Sarkis GJ: DNA sequence: structure and gene expression of mycobacteriophage L5: a phage system for mycobacterial genetics. Mol Microbiol. 7:395–405. 1993. View Article : Google Scholar : PubMed/NCBI

5 

Ford ME, Sarkis GJ, Belanger AE, et al: Genome structure of mycobacteriophage D29: implications for phage evolution. J Mol Biol. 279:143–164. 1998. View Article : Google Scholar : PubMed/NCBI

6 

Ford ME, Stenstrom C, Hendrix RW, et al: Mycobacteriophage TM4: genome structure and gene expression. Tuber Lung Dis. 79:63–73. 1998. View Article : Google Scholar

7 

Tokunaga T and Sellers M: Infection of Mycobacterium smegmatis with D29 phage DNA. J Exp Med. 119:139–149. 1964. View Article : Google Scholar : PubMed/NCBI

8 

Raj CV and Rama krishnan T: Transduction in Mycobacterium smegmatis. Nature. 228:280–281. 1970. View Article : Google Scholar : PubMed/NCBI

9 

Jacobs WR Jr, Snapper SB, Tuckman M and Bloom BR: Mycobacteriophage vector systems. Rev Infect Dis. 11:S404–S410. 1989. View Article : Google Scholar : PubMed/NCBI

10 

Jacobs WR Jr, Tuckman M and Bloom BR: Introduction of foreign DNA into mycobacteria using a shuttle phasmid. Nature. 327:532–535. 1987. View Article : Google Scholar : PubMed/NCBI

11 

Snapper SB, Lugosi L, Jekkelt A, et al: Lysogeny and transformation in mycobacteria: stable expression of foreign genes. Proc Natl Acad Sci USA. 85:6987–6991. 1988. View Article : Google Scholar : PubMed/NCBI

12 

Lee MH, Pascopella L, Jacobs WR Jr and Hatfull GF: Site-specific integration of mycobacteriophage L5: integration-proficient vectors for Mycobacterium smegmatis, Mycobacterium tuberculosis and bacille Calmette-Guérin. Proc Natl Acad Sci USA. 88:3111–3115. 1991. View Article : Google Scholar

13 

Bardarov S, Bardarov Jr S Jr, Pavelka Jr MS Jr, et al: Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in M. tuberculosis, M. bovis BCG and M. smegmatis. Microbiology. 148:3007–3017. 2002.PubMed/NCBI

14 

Bardarov S, Kriakov J, Carriere C, et al: Conditionally replicating mycobacteriophages: a system for transposon delivery to M. tuberculosis. Proc Natl Acad Sci USA. 94:10961–10966. 1997. View Article : Google Scholar

15 

Sassetti CM, Boyd DH and Rubin EJ: Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol. 48:77–84. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Jacobs WR Jr, Barletta RG, Udani R, et al: Rapid assessment of drug susceptibilities of M. tuberculosis by means of luciferase reporter phages. Science. 260:819–822. 1993. View Article : Google Scholar : PubMed/NCBI

17 

Piuri M, Jacobs WR Jr and Hatfull GF: Fluoromycobacteriophages for rapid, specific and sensitive antibiotic susceptibility testing of M. tuberculosis. PLoS One. 4:e48702009. View Article : Google Scholar

18 

World Health Organization: Global tuberculosis control: WHO report 2011. WHO, Geneva: 2011

19 

Pholwat S, Ehdaie B, Foongladda S, Kelly K and Houpt E: Real-time PCR using mycobacteriophage DNA for rapid phenotypic drug susceptibility results for Mycobacterium tuberculosis. J Clin Microbiol. 50:754–761. 2012. View Article : Google Scholar :

20 

Tokunaga T and Sellers MI: Streptomycin induction of premature lysis of bacteriophage-infected mycobacteria. J Bacteriol. 89:537–538. 1965.PubMed/NCBI

21 

Phillips LM and Sellers MI: Effects of ethambutol, actinomycin D and mitomycin C on the biosynthesis of D29-infected mycobacterium smegmatis. Host-virus relationships in mycobacterium, nocardia and actinomyces. Juhasz SE and Plummer G: Charles C. Thomas; Springfield: pp. 80–102. 1970

22 

David HL, Clavel S, Clement F and Moniz-Pereira J: Effects of antituberculosis and antileprosy drugs on mycobacteriophage D29 growth. Antimicrob Agents Chemother. 18:357–359. 1980. View Article : Google Scholar : PubMed/NCBI

23 

Wilson SM, al-Suwaidi Z, McNerney R, et al: Evaluation of a new rapid bacteriophage-based method for the drug susceptibility testing of Mycobacterium tuberculosis. Nat Med. 3:465–468. 1997. View Article : Google Scholar : PubMed/NCBI

24 

McNerney R, Wilson SM, Sidhu AM, et al: Inactivation of mycobacteriophage D29 using ferrous ammonium sulphate as a tool for the detection of viable Mycobacterium smegmatis and M. tuberculosis. Res Microbiol. 149:487–495. 1998. View Article : Google Scholar : PubMed/NCBI

25 

Mole RJ and Maskell TW: Phage as a diagnostic - the use of phage in TB diagnosis. J Chem Technol Biotechnol. 76:683–688. 2001. View Article : Google Scholar

26 

Seaman T, Trollip A, Mole R, et al: The use of a novel phage-based technology as a practical tool for the diagnosis of tuberculosis in Africa. Afr J Biotechnol. 2:40–45. 2003. View Article : Google Scholar

27 

Marei AM, El-Behedy EM, Mohtady HA and Afify AF: Evaluation of a rapid bacteriophage-based method for the detection of Mycobacterium tuberculosis in clinical samples. J Med Microbiol. 52:331–335. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Muzaffar R, Batool S, Aziz F, et al: Evaluation of the FASTPlaqueTB assay for direct detection of Mycobacterium tuberculosis in sputum specimens. Int J Tuberc Lung Dis. 6:635–640. 2002.PubMed/NCBI

29 

Albert H, Trollip AP, Mole RJ, et al: Rapid indication of multidrug-resistant tuberculosis from liquid cultures using FASTPlaqueTB-RIF™, a manual phage-based test. Int J Tuberc Lung Dis. 6:523–528. 2002.PubMed/NCBI

30 

Alcaide F, Galí N, Domínguez J, et al: Usefulness of a new mycobacteriophage-based technique for rapid diagnosis of pulmonary tuberculosis. J Clin Microbiol. 41:2867–2871. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Kalantri S, Pai M, Pascopella L, et al: Bacteriophage-based tests for the detection of Mycobacterium tuberculosis in clinical specimens: a systematic review and meta-analysis. BMC Infect Dis. 5:592005. View Article : Google Scholar

32 

Foundation for Innovative New Diagnostics (FIND): FIND interrupts demonstration projects using phage-based assays for detection of rifampin resistance. Geneva, Switzerland: FIND; 3–October. 2007, http://www.finddiagnostics.org/media/news/index.jsp?year=2007&domain. Accessed 16 May, 2014.

33 

Sarkis GJ, Jacobs WR Jr and Hatfull GF: L5 luciferase reporter mycobacteriophages: a sensitive tool for the detection and assay of live mycobacteria. Mol Microbiol. 15:1055–1067. 1995. View Article : Google Scholar : PubMed/NCBI

34 

Pearson RE, Jurgensen S, Sarkis GJ, et al: Construction of D29 shuttle phasmids and luciferase reporter phages for detection of mycobacteria. Gene. 183:129–136. 1996. View Article : Google Scholar : PubMed/NCBI

35 

Kumar V, Loganathan P, Sivaramakrishnan G, et al: Characterization of temperate phage Che12 and construction of a new tool for diagnosis of tuberculosis. Tuberculosis (Edinb). 88:616–623. 2008. View Article : Google Scholar

36 

Carrière C, Riska PF, Zimhony O, et al: Conditionally replicating luciferase reporter phages: improved sensitivity for rapid detection and assessment of drug susceptibility of Mycobacterium tuberculosis. J Clin Microbiol. 35:3232–3239. 1997.PubMed/NCBI

37 

Riska PF, Jacobs WR Jr, Bloom BR, et al: Specific identification of M. tuberculosis with the luciferase reporter mycobacte-riophage: use of p-nitro-alpha-acetylamino-beta-hydroxy propiophenone. J Clin Microbiol. 35:3225–3231. 1997.PubMed/NCBI

38 

Dye C, Scheele S, Dolin P, Pathania V and Raviglione MC: Consensus statement. Global burden of tuberculosis: Estimated incidence, prevalence, and mortality by country WHO Global Surveillance and Monitoring Project. JAMA. 282:677–686. 1999. View Article : Google Scholar : PubMed/NCBI

39 

Dusthackeer A, Kumar V, Subbian S, et al: Construction and evaluation of luciferase reporter phages for the detection of active and non-replicating tubercle bacilli. J Microbiol Methods. 73:18–25. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Dusthackeer VN, Balaji S, Gomathi NS, et al: Diagnostic luciferase reporter phage assay for active and non-replicating persistors to detect tubercle bacilli from sputum samples. Clin Microbiol Infect. 18:492–496. 2012. View Article : Google Scholar

41 

Banaiee N, January V, Barthus C, et al: Evaluation of a semi-automated reporter phage assay for susceptibility testing of Mycobacterium tuberculosis isolates in South Africa. Tuberculosis (Edinb). 88:64–68. 2008. View Article : Google Scholar

42 

Minion J and Pai M: Bacteriophage assays for rifampicin resistance detection in Mycobacterium tuberculosis: updated meta-analysis. Int J Tuberc Lung Dis. 14:941–951. 2010.PubMed/NCBI

43 

Rondón L, Piuri M, Jacobs WR Jr, et al: Evaluation of fluoromycobacteriophages for detecting drug resistance in Mycobacterium tuberculosis. J Clin Microbiol. 49:1838–1842. 2011. View Article : Google Scholar : PubMed/NCBI

44 

da Silva JL, Piuri M, Broussard G, et al: Application of BRED technology to construct recombinant D29 reporter phage expressing EGFP. FEMS Microbiol Lett. 344:166–172. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Piuri M, Rondón L, Urdániz E and Hatfull GF: Generation of affinity-tagged fluoromycobacteriophages by mixed assembly of phage capsids. Appl Environ Microbiol. 79:5608–5615. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fu X, Ding M, Zhang N and Li J: Mycobacteriophages: An important tool for the diagnosis of Mycobacterium tuberculosis (Review). Mol Med Rep 12: 13-19, 2015.
APA
Fu, X., Ding, M., Zhang, N., & Li, J. (2015). Mycobacteriophages: An important tool for the diagnosis of Mycobacterium tuberculosis (Review). Molecular Medicine Reports, 12, 13-19. https://doi.org/10.3892/mmr.2015.3440
MLA
Fu, X., Ding, M., Zhang, N., Li, J."Mycobacteriophages: An important tool for the diagnosis of Mycobacterium tuberculosis (Review)". Molecular Medicine Reports 12.1 (2015): 13-19.
Chicago
Fu, X., Ding, M., Zhang, N., Li, J."Mycobacteriophages: An important tool for the diagnosis of Mycobacterium tuberculosis (Review)". Molecular Medicine Reports 12, no. 1 (2015): 13-19. https://doi.org/10.3892/mmr.2015.3440
Copy and paste a formatted citation
x
Spandidos Publications style
Fu X, Ding M, Zhang N and Li J: Mycobacteriophages: An important tool for the diagnosis of Mycobacterium tuberculosis (Review). Mol Med Rep 12: 13-19, 2015.
APA
Fu, X., Ding, M., Zhang, N., & Li, J. (2015). Mycobacteriophages: An important tool for the diagnosis of Mycobacterium tuberculosis (Review). Molecular Medicine Reports, 12, 13-19. https://doi.org/10.3892/mmr.2015.3440
MLA
Fu, X., Ding, M., Zhang, N., Li, J."Mycobacteriophages: An important tool for the diagnosis of Mycobacterium tuberculosis (Review)". Molecular Medicine Reports 12.1 (2015): 13-19.
Chicago
Fu, X., Ding, M., Zhang, N., Li, J."Mycobacteriophages: An important tool for the diagnosis of Mycobacterium tuberculosis (Review)". Molecular Medicine Reports 12, no. 1 (2015): 13-19. https://doi.org/10.3892/mmr.2015.3440
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