Serum pentraxin 3 is a novel marker in Crohn's disease

Chen,Jingbo; Xu,Xiaolin; Xia,Lijian; Xi,Xiangpeng; Liu,Bo; Yang,Mingyu

doi:10.3892/mmr.2015.3451

July-2015 Volume 12 Issue 1

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

July-2015 Volume 12 Issue 1

Full Size Image

Article

Serum pentraxin 3 is a novel marker in Crohn's disease

Authors:
- Jingbo Chen
- Xiaolin Xu
- Lijian Xia
- Xiangpeng Xi
- Bo Liu
- Mingyu Yang
View Affiliations / Copyright

Affiliations: Department of Gastrointestinal Surgery, Qianfoshan Hospital of Shandong Province, Jinan, Shandong 250014, P.R. China
Pages: 543-546
|
Published online on: March 6, 2015

https://doi.org/10.3892/mmr.2015.3451
Expand metrics +

Abstract

In Crohn's disease (CD), clinical symptoms correspond poorly to inflammatory disease activity. Biomarkers, which reflect the level of intestinal inflammation are considered to enable effective monitoring of disease activity. The present study evaluated the role of serum pentraxin 3 (PTX3) as a marker of disease activity in patients with CD. Serum PTX3 levels were determined using an enzyme‑linked immunosorbent assay in patients with CD (n=240), ulcerative colitis (UC; n=240) and healthy controls (HC; n=80). The expression levels of PTX3 were also evaluated in 35 fresh colonic tissue samples by western blot analysis. The association between levels of serum PTX3 with disease activity and its diagnostic role were analyzed. The levels of serum PTX3 were significantly increased in patients with active CD compared with patients in remission (UC and HC; P<0.01). A significant increase in the expression levels of PTX3 was identified at a protein level in inflamed colonic tissues compared with uninflamed colonic tissues. The levels of serum PTX3 were also positively correlated with disease activity in CD. These results indicated that serum and colonic expression of PTX3 were upregulated in patients with active CD, suggesting serum PTX3 is superior to CRP in predicting CD activity.

View Figures

View References

1	Xavier RJ and Podolsky DK: Unravelling the pathogenesis of inflammatory bowel disease. Nature. 448:427–434. 2007. View Article : Google Scholar : PubMed/NCBI
2	Lewis JD: The utility of biomarkers in the diagnosis and therapy of inflammatory bowel disease. Gastroenterology. 140:1817–1826. 2011. View Article : Google Scholar : PubMed/NCBI
3	Wang YF, Ouyang Q and Hu RW: Progression of inflammatory bowel disease in China. J Dig Dis. 11:76–82. 2010. View Article : Google Scholar : PubMed/NCBI
4	Lahiff C, Safaie P, Awais A, et al: The Crohn’s disease activity index (CDAI) is similarly elevated in patients with Crohn’s disease and in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 37:786–794. 2013. View Article : Google Scholar : PubMed/NCBI
5	Alles VV, Bottazzi B, Peri G, Golay J, Introna M and Mantovani A: Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes. Blood. 84:3483–3493. 1994.PubMed/NCBI
6	Klouche M, Peri G, Knabbe C, Eckstein HH, Schmid FX, Schmitz G and Mantovani A: Modified atherogenic lipoproteins induce expression of pentraxin-3 by human vascular smooth muscle cells. Atherosclerosis. 175:221–228. 2004. View Article : Google Scholar : PubMed/NCBI
7	Fazzini F, Peri G, Doni A, et al: PTX3 in small-vessel vasculitides: an independent indicator of disease activity produced at sites of inflammation. Arthritis Rheum. 44:2841–2850. 2001. View Article : Google Scholar
8	Baldini M, Maugeri N, Ramirez GA, et al: Selective up-regulation of the soluble pattern-recognition receptor pentraxin 3 and of vascular endothelial growth factor in giant cell arteritis: relevance for recent optic nerve ischemia. Arthritis Rheum. 64:854–865. 2012. View Article : Google Scholar
9	Lennard-Jones JE: Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl. 170:2–6. 1989. View Article : Google Scholar : PubMed/NCBI
10	Benitez JM, Meuwis MA, Reenaers C, Van Kemseke C, Meunier P and Louis E: Role of endoscopy, cross-sectional imaging and biomarkers in Crohn’s disease monitoring. Gut. 62:1806–1816. 2013. View Article : Google Scholar : PubMed/NCBI
11	Mantovani A, Valentino S, Gentile S, Inforzato A, Bottazzi B and Garlanda C: The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules. Ann NY Acad Sci. 1285:1–14. 2013. View Article : Google Scholar : PubMed/NCBI
12	Kunes P, Holubcova Z, Kolackova M and Krejsek J: Pentraxin 3(PTX 3): an endogenous modulator of the inflammatory response. Mediators Inflamm. 2012:9205172012. View Article : Google Scholar : PubMed/NCBI
13	Kusnierz-Cabala B, Gurda-Duda A, Dumnicka P, Panek J, Pawlica-Gosiewska D, Kulig J and Solnica B: Plasma pentraxin 3 concentrations in patients with acute pancreatitis. Clin Lab. 59:1003–1008. 2013.PubMed/NCBI
14	Bottazzi B, Doni A, Garlanda C and Mantovani A: An integrated view of humoral innate immunity: pentraxins as a paradigm. Annu Rev Immunol. 28:157–183. 2010. View Article : Google Scholar
15	Sjöberg B, Qureshi AR, Anderstam B, Alvestrand A and Bárány P: Pentraxin 3, a sensitive early marker of hemodialysis-induced inflammation. Blood Purif. 34:290–297. 2012. View Article : Google Scholar : PubMed/NCBI
16	Lin Q, Fu F, Shen L and Zhu B: Pentraxin 3 in the assessment of ventilator-associated pneumonia: an early marker of severity. Heart Lung. 42:139–145. 2013. View Article : Google Scholar : PubMed/NCBI
17	Hudzik B, Szkodzinski J, Pietka-Rzycka A, et al: Plasma pentraxin 3 may be a more sensitive marker of inflammatory response than high-sensitivity C-reactive protein after bare-metal stent compared to drug-eluting stent implantation. J Interferon Cytokine Res. 33:280–284. 2013. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Serum pentraxin 3 is a novel marker in Crohn's disease

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Related Articles