Positive and negative regulators of the metallothionein gene (Review)

  • Authors:
    • Shinichiro Takahashi
  • View Affiliations

  • Published online on: March 9, 2015     https://doi.org/10.3892/mmr.2015.3459
  • Pages: 795-799
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Metallothioneins (MTs) are metal‑binding proteins involved in diverse processes, including metal homeostasis and detoxification, the oxidative stress response and cell proliferation. Aberrant expression and silencing of these genes are important in a number of diseases. Several positive regulators of MT genes, including metal‑responsive element‑binding transcription factor (MTF)‑1 and upstream stimulatory factor (USF)‑1, have been identified and mechanisms of induction have been well described. However, the negative regulators of MT genes remain to be elucidated. Previous studies from the group of the present review have revealed that the hematopoietic master transcription factor, PU.1, directly represses the expression levels of MT genes through its epigenetic activities, and upregulation of MT results in the potent inhibition of myeloid differentiation. The present review focuses on PU.1 and several other negative regulators of this gene, including PZ120, DNA methyltransferase 3a with Mbd3 and Brg1 complex, CCAAT enhancer binding protein α and Ku protein, and describes the suppression of the MT genes through these transcription factors.
View Figures
View References

Related Articles

Journal Cover

July-2015
Volume 12 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Takahashi S: Positive and negative regulators of the metallothionein gene (Review). Mol Med Rep 12: 795-799, 2015
APA
Takahashi, S. (2015). Positive and negative regulators of the metallothionein gene (Review). Molecular Medicine Reports, 12, 795-799. https://doi.org/10.3892/mmr.2015.3459
MLA
Takahashi, S."Positive and negative regulators of the metallothionein gene (Review)". Molecular Medicine Reports 12.1 (2015): 795-799.
Chicago
Takahashi, S."Positive and negative regulators of the metallothionein gene (Review)". Molecular Medicine Reports 12, no. 1 (2015): 795-799. https://doi.org/10.3892/mmr.2015.3459