Lipid metabolism disorders and bone dysfunction - interrelated and mutually regulated (Review)

Tian,Li; Yu,Xijie

doi:10.3892/mmr.2015.3472

July-2015 Volume 12 Issue 1

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July-2015 Volume 12 Issue 1

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Review Open Access

Lipid metabolism disorders and bone dysfunction - interrelated and mutually regulated (Review)

Authors:
- Li Tian
- Xijie Yu
View Affiliations / Copyright

Affiliations: Laboratory of Endocrinology and Metabolism, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China

Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
Pages: 783-794
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Published online on: March 11, 2015

https://doi.org/10.3892/mmr.2015.3472
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Abstract

The association between lipid and bone metabolism has become an increasing focus of interest in recent years, and accumulating evidence has shown that atherosclerosis (AS) and osteoporosis (OP), a disorder of bone metabolism, frequently co‑exist. Fat and bone are known to share a common progenitor cell: Multipotent mesenchymal stem cells (MSC) in the bone marrow (BM), which are able to differentiate into various cell phenotypes, including osteoblasts, adipocytes and chondrocytes. Laboratory‑based and clinical trials have shown that increasing adipocytes are accompanied by a decrease in bone mineral density (BMD) and bone mass. Statins, lipid‑lowering drugs used to treat hyperlipidemia, also provide benefit in the treatment of OP. There is thus evidence that the metabolism of lipids is correlated with that of bone, and that the two are mutually regulated. The present review primarily focuses on the potential association between lipid metabolism disturbance and OP, based on biological metabolism, pathophysiological processes, results from clinical and experimental animal studies, processes involved in the differentiation of adipocytes and osteoblasts, as well as pharmacological treatments of these diseases.

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