Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-2015 Volume 12 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2015 Volume 12 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Verifying the markers of ovarian cancer using RNA‑seq data

  • Authors:
    • Tianfeng Liu
    • Nina Yu
    • Feng Ding
    • Surong Wang
    • Shihong Li
    • Xiaofei Zhang
    • Xiangxiu Sun
    • Ying Chen
    • Peishu Liu
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Linyi People's Hospital, Linyi, Shandong 276000, P.R. China, Department of Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong 250000, P.R. China
  • Pages: 1125-1130
    |
    Published online on: March 13, 2015
       https://doi.org/10.3892/mmr.2015.3489
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Markers associated with diagnosis, presentation and potential therapeutic targets have received widespread attention in ovarian cancer research in the past few years. However, the majority of these markers have been investigated individually, and the changes in expression and the association between them are rarely documented. Next‑generation sequencing, also termed RNA‑seq when the sequencing targets are cDNAs, can provide a whole blueprint of the transcriptome of a specific tissue. In the present study, RNA‑seq data of human ovarian cancer samples were used to verify the expression of known markers and to identify the association between them. A total of 563 markers associated with ovarian cancer were retrieved from the database of the National Center of Biotechnology Information, and used as the target markers. The transcriptome of the ovarian tissue of four different tumors, containing tumor presentation and recurrence stages, were sequenced using the Illumina GAII platform. Approximately 85.97% markers were expressed of the total 563 markers, and the majority of them were involved in pathways associated with cancer, signaling and infection. In total, 85 markers were found to be aberrantly expressed in tumor cells from patients with ovarian cancer who had recurrences, including 33 upregulated markers at the recurrence stage. Therefore, they may have roles ovarian tumor due to their aberrant expression. Differentially expressed markers and the associations between them can be assessed by examining the RNA‑seq data. These findings may provide novel information for further studies on ovarian cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Moss EL, Hollingworth J and Reynolds TM: The role of CA125 in clinical practice. J Clin Pathol. 58:308–312. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Lakhani SR, Manek S, Penault-Llorca F, et al: Pathology of ovarian cancers in BRCA1 and BRCA2 carriers. Clin Cancer Res. 10:2473–2481. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Rafnar T, Gudbjartsson DF, Sulem P, et al: Mutations in BRIP1 confer high risk of ovarian cancer. Nat Genet. 43:1104–1107. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Ducros E, Mirshahi S, Azzazene D, et al: Endothelial protein C receptor expressed by ovarian cancer cells as a possible biomarker of cancer onset. Int J Oncol. 41:433–440. 2012.PubMed/NCBI

5 

Fung FK, Chan DW, Liu VW, Leung TH, Cheung AN and Ngan HY: Increased expression of PITX2 transcription factor contributes to ovarian cancer progression. PLoS One. 7:e370762012. View Article : Google Scholar : PubMed/NCBI

6 

Ishibashi M, Nakayama K, Yeasmin S, et al: A BTB/POZ gene, NAC-1, a tumor recurrence-associated gene, as a potential target for taxol resistance in ovarian cancer. Clin Cancer Res. 14:3149–3155. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Rajkumar T, Soumittra N, Nancy NK, Swaminathan R, Sridevi V and Shanta V: BRCA1, BRCA2 and CHEK2 (1100 del C) germline mutations in hereditary breast and ovarian cancer families in south india. Asian Pac J Cancer Prev. 4:203–208. 2003.PubMed/NCBI

8 

Ghadersohi A, Odunsi K, Zhang S, et al: Prostate-derived Ets transcription factor as a favorable prognostic marker in ovarian cancer patients. Int J Cancer. 123:1376–1384. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Tassi RA, Calza S, Ravaggi A, et al: Mammaglobin B is an independent prognostic marker in epithelial ovarian cancer and its expression is associated with reduced risk of disease recurrence. BMC Cancer. 9:2532009. View Article : Google Scholar : PubMed/NCBI

10 

Rahman M, Nakayama K, Rahman M, et al: Fatty acid synthase expression associated with NAC1 is a potential therapeutic target in ovarian clear cell carcinomas. Brit J Cancer. 107:300–307. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Ng CK, Cooke SL, Howe K, et al: The role of tandem duplicator phenotype in tumour evolution in high-grade serous ovarian cancer. J Pathol. 226:703–712. 2012. View Article : Google Scholar

12 

Ahmed AA, Mills AD, Ibrahim AE, et al: The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel. Cancer Cell. 12:514–527. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Krueger F, Kreck B, Franke A and Andrews SR: DNA methylome analysis using short bisulfite sequencing data. Nat Methods. 9:145–151. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Madougou S, Santcroos M, Benabdelkader A, et al: Provenance for distributed biomedical workflow execution. Stud Health Technol Inform. 175:91–100. 2012.PubMed/NCBI

15 

Mao X, Cai T, Olyarchuk JG and Wei L: Automated genome annotation and pathway identification using the KEGG orthology (KO) as a controlled vocabulary. Bioinformatics. 21:3787–3793. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Langmead B, Trapnell C, Pop M and Salzberg SL: Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol. 10:R252009. View Article : Google Scholar : PubMed/NCBI

17 

Mortazavi A, Williams BA, Mccue K, Schaeffer L and Wold B: Mapping and quantifying mammalian transcriptomes by RNA-seq. Nat Methods. 5:621–628. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Audic S and Claverie JM: The significance of digital gene expression profiles. Genome Res. 7:986–995. 1997.PubMed/NCBI

19 

Benjamini Y and Yekutieli D: The control of the false discovery rate in multiple testing under dependency. Ann Stat. 29:1165–1188. 2001.

20 

Harr B and Schlötterer C: Comparison of algorithms for the analysis of affymetrix microarray data as evaluated by co-expression of genes in known operons. Nucleic Acids Res. 34:e82006. View Article : Google Scholar : PubMed/NCBI

21 

Adamidi C, Wang Y, Gruen D, et al: De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics. Genome Res. 21:1193–1200. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Virtakoivu R, Pellinen T, Rantala JK, Perälä M and Ivaska J: Distinct roles of AKT isoforms in regulating β1-integrin activity, migration and invasion in prostate cancer. Mol Biol Cell. 23:3357–3369. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Dobashi Y, Kimura M, Matsubara H, Endo S, Inazawa J and Ooi A: Molecular alterations in AKT and its protein activation in human lung carcinomas. Hum Pathol. 43:2229–2240. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Bellacosa A, De Feo D, Godwin AK, et al: Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas. Int J Cancer. 64:280–285. 1995. View Article : Google Scholar : PubMed/NCBI

25 

Altomare DA, Wang HQ, Skele KL, et al: AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene. 23:5853–5857. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Chu CM: Natural history of chronic hepatitis B virus infection in adults with emphasis on the occurrence of cirrhosis and hepatocellular carcinoma. J Gastroen Hepatol. 15:E25–E30. 2000. View Article : Google Scholar

27 

Parsonnet J, Friedman GD, Vandersteen DP, et al: Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med. 325:1127–1131. 1991. View Article : Google Scholar : PubMed/NCBI

28 

Sobhani I, Walker F, Roudot-Thoraval F, et al: Anal carcinoma: incidence and effect of cumulative infections. Aids. 18:1561–1569. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Dreesen O and Brivanlou AH: Signaling pathways in cancer and embryonic stem cells. Stem Cell Rev. 3:7–17. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Osman I, Drobnjak M, Fazzari M, et al: Inactivation of the p53 pathway in prostate cancer: impact on tumor progression. Clin Cancer Res. 5:2082–2088. 1999.PubMed/NCBI

31 

Puzio-Kuter AM, Castillo-Martin M, Kinkade CW, et al: Inactivation of p53 and Pten promotes invasive bladder cancer. Genes Dev. 23:675–680. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Ho SM: Estrogen, progesterone and epithelial ovarian cancer. Reprod Biol Endocrinol. 1:732003. View Article : Google Scholar : PubMed/NCBI

33 

Pópulo H, Lopes JM and Soares P: The mTOR signalling pathway in human cancer. Int J Mol Sci. 13:1886–1918. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Guerrero K, Wang Z, Bachvarova M, et al: A novel genome-based approach correlates TMPRSS3 overexpression in ovarian cancer with DNA hypomethylation. Gynecol Oncol. 125:720–726. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Byrne J, Maleki S, Hardy JR, et al: MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome. BMC cancer. 10:4972010. View Article : Google Scholar : PubMed/NCBI

36 

Guo Y, Fu P, Zhu H, et al: Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer. Oncol Rep. 27:286–292. 2012.

37 

Hwang JR, Jo K, Lee Y, Sung BJ, Park YW and Lee JH: Upregulation of CD9 in ovarian cancer is related to the induction of TNF-α gene expression and constitutive NF-κB activation. Carcinogenesis. 33:77–83. 2012. View Article : Google Scholar

38 

Seiz L, Dorn J, Kotzsch M, et al: Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients. Biol Chem. 393:391–401. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Bock AJ, Nymoen DA, Brenne K, Kærn J and Davidson B: SCARA3 mRNA is overexpressed in ovarian carcinoma compared with breast carcinoma effusions. Hum Pathol. 43:669–674. 2012. View Article : Google Scholar

40 

Chuan Y, Pang ST, Bergh A, Norstedt G and Pousette A: Androgens induce CD-9 in human prostate tissue. Int J Androl. 28:291–296. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Cook GA, Wilkinson DA, Crossno JT Jr, Raghow R and Jennings LK: The tetraspanin CD9 influences the adhesion, spreading and pericellular fibronectin matrix assembly of chinese hamster ovary cells on human plasma fibronectin. Exp Cell Res. 251:356–371. 1999. View Article : Google Scholar : PubMed/NCBI

42 

Furuya M, Kato H, Nishimura N, et al: Down-regulation of CD9 in human ovarian carcinoma cell might contribute to peritoneal dissemination: morphologic alteration and reduced expression of β1 integrin subsets. Cancer Res. 65:2617–2625. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Notaridou M, Quaye L, Dafou D, et al: Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer. Int J Cancer. 128:2063–2074. 2011. View Article : Google Scholar :

44 

Acampora D, D’esposito M, Faiella A, et al: The human hox gene family. Nucleic Acids Res. 17:10385–10402. 1989. View Article : Google Scholar : PubMed/NCBI

45 

Ota T, Klausen C, Salamanca MC, Woo HL, Leung PC and Auersperg N: Expression and function of HOXA genes in normal and neoplastic ovarian epithelial cells. Differentiation. 77:162–171. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Gendronneau G, Boucherat O, Aubin J, Lemieux M and Jeannotte L: The loss of Hoxa5 function causes estrous acyclicity and ovarian epithelial inclusion cysts. Endocrinology. 153:1484–1497. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Morgan R, Plowright L, Harrington KJ, Michael A and Pandha HS: Targeting HOX and PBX transcription factors in ovarian cancer. BMC cancer. 10:892010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu T, Yu N, Ding F, Wang S, Li S, Zhang X, Sun X, Chen Y and Liu P: Verifying the markers of ovarian cancer using RNA‑seq data. Mol Med Rep 12: 1125-1130, 2015.
APA
Liu, T., Yu, N., Ding, F., Wang, S., Li, S., Zhang, X. ... Liu, P. (2015). Verifying the markers of ovarian cancer using RNA‑seq data. Molecular Medicine Reports, 12, 1125-1130. https://doi.org/10.3892/mmr.2015.3489
MLA
Liu, T., Yu, N., Ding, F., Wang, S., Li, S., Zhang, X., Sun, X., Chen, Y., Liu, P."Verifying the markers of ovarian cancer using RNA‑seq data". Molecular Medicine Reports 12.1 (2015): 1125-1130.
Chicago
Liu, T., Yu, N., Ding, F., Wang, S., Li, S., Zhang, X., Sun, X., Chen, Y., Liu, P."Verifying the markers of ovarian cancer using RNA‑seq data". Molecular Medicine Reports 12, no. 1 (2015): 1125-1130. https://doi.org/10.3892/mmr.2015.3489
Copy and paste a formatted citation
x
Spandidos Publications style
Liu T, Yu N, Ding F, Wang S, Li S, Zhang X, Sun X, Chen Y and Liu P: Verifying the markers of ovarian cancer using RNA‑seq data. Mol Med Rep 12: 1125-1130, 2015.
APA
Liu, T., Yu, N., Ding, F., Wang, S., Li, S., Zhang, X. ... Liu, P. (2015). Verifying the markers of ovarian cancer using RNA‑seq data. Molecular Medicine Reports, 12, 1125-1130. https://doi.org/10.3892/mmr.2015.3489
MLA
Liu, T., Yu, N., Ding, F., Wang, S., Li, S., Zhang, X., Sun, X., Chen, Y., Liu, P."Verifying the markers of ovarian cancer using RNA‑seq data". Molecular Medicine Reports 12.1 (2015): 1125-1130.
Chicago
Liu, T., Yu, N., Ding, F., Wang, S., Li, S., Zhang, X., Sun, X., Chen, Y., Liu, P."Verifying the markers of ovarian cancer using RNA‑seq data". Molecular Medicine Reports 12, no. 1 (2015): 1125-1130. https://doi.org/10.3892/mmr.2015.3489
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team