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Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2α

  • Authors:
    • Rui‑Jun Li
    • Kun‑Lun He
    • Xin Li
    • Li‑Li Wang
    • Chun‑Lei Liu
    • Yun‑Yun He
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, P.R. China, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1043-1049
    |
    Published online on: March 18, 2015
       https://doi.org/10.3892/mmr.2015.3508
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Abstract

The aim of the present study was to examine the role of eIF2α in cardiomyocyte apoptosis and evaluate the cardioprotective role of salubrinal in a rat myocardial infarction (MI) model. Rat left anterior descending coronary arteries were ligated and the classical proteins involved in the endoplasmic reticulum stress (ERS)‑induced apoptotic pathway were analyzed using quantitative polymerase chain reaction and western blot analysis. Salubrinal was administered to the rats and cardiomyocyte apoptosis and infarct size were evaluated by a specific staining method. Compared with the sham surgery group, the rate of cardiomyocyte apoptosis in the MI group was increased with the development of the disease. It was also demonstrated that the mRNA and protein levels of GRP78, caspase‑12, CHOP and the protein expression of p‑eIF2α were increased in the MI group. Furthermore, the results showed that treatment with salubrinal can decrease cardiomyocyte apoptosis and infarct size by increasing eIF2α phosphorylation and decreasing the expression of caspase‑12 and CHOP. The present study suggests that salubrinal protects against ER stress‑induced rat cadiomyocyte apoptosis via suppressing the dephosphorylation of eIF2α in the ERS-associated pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Li RJ, He KL, Li X, Wang LL, Liu CL and He YY: Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2α. Mol Med Rep 12: 1043-1049, 2015.
APA
Li, R., He, K., Li, X., Wang, L., Liu, C., & He, Y. (2015). Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2α. Molecular Medicine Reports, 12, 1043-1049. https://doi.org/10.3892/mmr.2015.3508
MLA
Li, R., He, K., Li, X., Wang, L., Liu, C., He, Y."Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2α". Molecular Medicine Reports 12.1 (2015): 1043-1049.
Chicago
Li, R., He, K., Li, X., Wang, L., Liu, C., He, Y."Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2α". Molecular Medicine Reports 12, no. 1 (2015): 1043-1049. https://doi.org/10.3892/mmr.2015.3508
Copy and paste a formatted citation
x
Spandidos Publications style
Li RJ, He KL, Li X, Wang LL, Liu CL and He YY: Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2α. Mol Med Rep 12: 1043-1049, 2015.
APA
Li, R., He, K., Li, X., Wang, L., Liu, C., & He, Y. (2015). Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2α. Molecular Medicine Reports, 12, 1043-1049. https://doi.org/10.3892/mmr.2015.3508
MLA
Li, R., He, K., Li, X., Wang, L., Liu, C., He, Y."Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2α". Molecular Medicine Reports 12.1 (2015): 1043-1049.
Chicago
Li, R., He, K., Li, X., Wang, L., Liu, C., He, Y."Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2α". Molecular Medicine Reports 12, no. 1 (2015): 1043-1049. https://doi.org/10.3892/mmr.2015.3508
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