|
1
|
Han W, Li L, Qiu S, Lu Q, Pan Q, Gu Y, Luo
J and Hu X: Shikonin circumvents cancer drug resistance by
induction of a necroptotic death. Mol Cancer Ther. 6:1641–1649.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Chen HM, Wang PH, Chen SS, Wen CC, Chen
YH, Yang WC and Yang NS: Shikonin induces immunogenic cell death in
tumor cells and enhances dendritic cell-based cancer vaccine.
Cancer Immunol Immunother. 61:1989–2002. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Chen X, Yang L, Zhang N, Turpin JA,
Buckheit RW, Osterling C, Oppenheim JJ and Howard OM: Shikonin, a
component of chinese herbal medicine, inhibits chemokine receptor
function and suppresses human immunodeficiency virus type 1.
Antimicrob Agents Chemother. 47:2810–2816. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Yeh CC, Kuo HM, Li TM, Lin JP, Yu FS, Lu
HF, Chung JG and Yang JS: Shikonin-induced apoptosis involves
caspase-3 activity in a human bladder cancer cell line (T24). In
vivo. 21:1011–1019. 2007.
|
|
5
|
Wiench B, Eichhorn T, Paulsen M and
Efferth T: Shikonin directly targets mitochondria and causes
mitochondrial dysfunction in cancer cells. Evid Based Complement
Alternat Med. 2012:7260252012.PubMed/NCBI
|
|
6
|
Lago CU, Sung HJ, Ma W, Wang PY and Hwang
PM: p53, aerobic metabolism, and cancer. Antioxid Redox Signal.
15:1739–1748. 2011. View Article : Google Scholar :
|
|
7
|
Vogelstein B, Lane D and Levine AJ:
SUrfing the p53 network. Nature. 408:307–310. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Levine AJ: p53, the cellular gatekeeper
for growth and division. Cell. 88:323–331. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Nigro JM, Baker SJ, Preisinger A, et al:
Mutations in the p53 gene occur in diverse human tumor types.
Nature. 342:705–708. 1989. View
Article : Google Scholar : PubMed/NCBI
|
|
10
|
Ryan KM, Phillips AC and Vousden KH:
Regulation and function of the p53 tumor suppressor protein. Curr
Opin Cell Biol. 13:332–337. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Wu Z, Wu LJ, Tashiro S, Onodera S and
Ikejima T: Phosphorylated extracellular signal-regulated kinase
up-regulated p53 expression in shikonin-induced HeLa cell
apoptosis. Chin Med J. 118:671–677. 2005.PubMed/NCBI
|
|
12
|
Hsu PC, Huang YT, Tsai ML, Wang YJ, Lin JK
and Pan MH: Induction of apoptosis by shikonin through coordinative
modulation of the Bcl-2 family, p27 and p53, release of cytochrome
c and sequential activation of caspases in human colorectal
carcinoma cells. J Agric Food Chem. 52:6330–6337. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Wu Z, Wu L, Li L, Tashiro S, Onodera S and
Ikejima T: p53-mediated cell cycle arrest and apoptosis induced by
shikonin via a caspase-9-dependent mechanism in human malignant
melanoma A375-S2 cells. J Pharmacol Sci. 94:166–176. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Tsao AS, McDonnell T, Lam S, Putnam JB,
Bekele N, Hong WK and Kurie JM: Increased phospho-AKT (Ser (473))
expression in bronchial dysplasia: implications for lung cancer
prevention studies. Cancer Epidemiol Biomarkers Prev. 12:660–664.
2003.PubMed/NCBI
|
|
15
|
Brognard J, Clark AS, Ni Y and Dennis PA:
Akt/protein kinase B is constitutively active in non-small cell
lung cancer cells and promotes cellular survival and resistance to
chemotherapy and radiation. Cancer Res. 61:3986–3997.
2001.PubMed/NCBI
|
|
16
|
Massion PP, Taflan PM, Shyr Y, et al:
Early involvement of the phosphatidylinositol 3-kinase/Akt pathway
in lung cancer progression. Am J Respir Crit Care Med.
170:1088–1094. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Rasul A, Yu B, Khan M, Zhang K, Iqbal F,
Ma T and Yang H: Magnolol, a natural compound, induces apoptosis of
SGC-7901 human gastric adenocarcinoma cells via the mitochondrial
and PI3K/Akt signaling pathways. Int J Oncol. 40:1153–1161.
2012.
|
|
18
|
Jung KH, Choi MJ, Hong S, Lee H, Hong SW,
Zheng HM, Lee HS, Hong S and Hong SS: HS-116, a novel
phosphati-dylinositol 3-kinase inhibitor induces apoptosis and
suppresses angiogenesis of hepatocellular carcinoma through
inhibition of the PI3K/AKT/mTOR pathway. Cancer Lett. 316:187–195.
2012. View Article : Google Scholar
|
|
19
|
Swaminathan G and Tsygankov AY: The Cbl
family proteins: ringleaders in regulation of cell signaling. J
Cell Physiol. 209:21–43. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Naramura M, Band V and Band H:
Indispensable roles of mammalian Cbl family proteins as negative
regulators of protein tyrosine kinase signaling: Insights from in
vivo models. Commun Integr Biol. 4:159–162. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Thien CB, Dagger SA and Steer JH: c-Cbl
promotes T cell receptor-induced thymocyte apoptosis by activating
the phosphatidylinositol 3-kinase/Akt Pathway. J Biol Chem.
285:10969–10981. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Mao X, Yu CR, Li WH and Li WX: Induction
of apoptosis by shikonin through a ROS/JNK-mediated process in
Bcr/Abl-positive chronic myelogenous leukemia (CMl) cells. Cell
Res. 18:879–888. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Chen CH, Chern CL, Lin CC, Lu FJ, Shih MK,
Hsieh PY and Liu TZ: Involvement of reactive oxygen species, but
not mitochondrial permeability transition in the apoptotic
induction of human SK-Hep-1 hepatoma cells by shikonin. Planta Med.
69:1119–1124. 2003. View Article : Google Scholar
|
|
24
|
Min R, Tong J, Wenjun Y, Wenhu D, Xiaojian
Z, Jiacai H, Jian Z, Wantao C and Chenping Z: Growth inhibition and
induction of apoptosis in human oral squamous cell carcinoma
Tca-8113 cell lines by Shikonin was partly through the inactivation
of NF-kappaB pathway. Phytother Res. 22:407–415. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Yao Y and Zhou Q: A novel antiestrogen
agent Shikonin inhibits estrogen-dependent gene transcription in
human breast cancer cells. Breast Cancer Res Treat. 121:233–240.
2010. View Article : Google Scholar
|
|
26
|
Yingkun N, Lvsong Z and Huimin Y: Shikonin
inhibits the proliferation and induces the apoptosis of human HepG2
cells. Can J Physiol Pharmacol. 88:1138–1146. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Chang IC, Huang YJ, Chiang TI, Yeh CW and
Hsu LS: Shikonin induces apoptosis through reactive oxygen
species/extracellular signal-regulated kinase pathway in
osteosarcoma cells. Biol Pharm Bull. 33:816–824. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Yang H, Zhou P, Huang H, et al: Shikonin
exerts antitumor activity via proteasome inhibition and cell death
induction in vitro and in vivo. Int I Cancer. 124:2450–2459. 2009.
View Article : Google Scholar
|
|
29
|
Wu Z, Wu LJ, Li LH, Tashiro S, Onodera S
and Ikejima T: Shikonin regulates HeLa cell death via caspase-3
activation and blockage of DNA synthesis. J Asian Nat Prod Res.
6:155–166. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Afford S and Randhawa S: Apoptosis. Mol
Pathol. 53:55–63. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Lee DH, Kim C, Zhang L and Lee YJ: Role of
p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer
cells. Biochem Pharmacol. 75:2020–2033. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Donovan M and Cotter TG: Control of
mitochondrial integrity by Bcl-2 family members and
caspase-independent cell death. Biochim Biophys Acta. 1644:133–147.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Anilkumar U and Prehn JH: Anti-apoptotic
BCL-2 family proteins in acute neural injury. Front Cell Neurosci.
8:2812014. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Wang W, Guo Q, You Q, et al: Involvement
of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell
line SMMC-7721. Anticancer Drugs. 17:797–805. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Taylor WR and Stark GR: Regulation of the
G2/M transition by p53. Oncogene. 20:1803–1815. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Kastan MB and Kuerbitz SJ: Control of G1
arrest after DNA damage. Environ Health Perspect. 101:55–58.
1993.PubMed/NCBI
|
|
37
|
Lee DH, Rhee JG and Lee YJ: Reactive
oxygen species up-regulate p53 and Puma; a possible mechanism for
apoptosis during combined treatment with TRAIL and wogonin. Br J
Pharmacol. 157:1189–1202. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Li Y, Qu X, Qu J, Zhang Y, Liu J, Teng Y,
Hu X, Hou K and Liu Y: Arsenic trioxide induces apoptosis and
G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt
signaling and thereby regulate p53 activation. Cancer Lett.
284:208–215. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Scorrano L, Oakes SA, Opferman JT, Cheng
EH, Sorcinelli MD, Pozzan T and Korsmeyer SJ: BAX and Bak
regulation of endoplasmic reticulum Ca2+: a control point for
apoptosis. Science. 300:135–139. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Datta SR, Brunet A and Greenberg ME:
Cellular survival: A play in three Akts. Genes Dev. 13:2905–2927.
1999. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Brader S and Eccles SA: Phosphoinositide
3-kinase signalling pathways in tumor progression, invasion and
angiogenesis. Tumori. 90:2–8. 2004.PubMed/NCBI
|
|
42
|
Suthiphongchai T, Promyart P, Virochrut S,
Tohtong R and Wilairat P: Involvement of ERKI/2 in invasiveness and
metastatic development of rat prostatic Adenocarcinoma. Oncol Res.
13:253–259. 2003.
|
|
43
|
Tang YQ, Jaganath I, Manikam R and Sekaran
SD: Phyllanthus suppresses prostate cancer cell, PC-3,
proliferation and induces apoptosis through multiple signalling
pathways (MAPKs, PI3K/Akt, NFκB and Hypoxia). Evid Based Complement
Alternat Med. 2013:6095812013. View Article : Google Scholar
|
|
44
|
Gong K and Li W: Shikonin, a Chinese
plant-derived naphthoquinone, induces apoptosis in hepatocellular
carcinoma cells through reactive oxygen species: A potential new
treatment for hepatocellular carcinoma. Free Riadic Biol Med.
51:2259–2271. 2011. View Article : Google Scholar
|
