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Article

Comparative analysis of the influence of Fructus Ligustri Lucidi on a rat lumbar disc herniation model

  • Authors:
    • Ya‑Xin Han
    • Dong Liang
    • Xiao‑Rui Han
    • De‑Yong Liang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
  • Pages: 1225-1232
    |
    Published online on: March 24, 2015
       https://doi.org/10.3892/mmr.2015.3547
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Abstract

Lumbar disc herniation (LDH) is a term used for a group of conditions, including back pain, femoral nerve pain and sciatica. Currently available treatments and surgical options are insufficient for patients with LDH. Fructus Ligustri Lucidi (FLL) is a herb that is used for treating age‑associated diseases. The results of the present study suggested that FLL may be used for treatment of patients with LDH. In the present study, matrix metalloproteinase‑1, ‑3, ‑8 and ‑9 (MMP‑1, ‑3, ‑8 and ‑9) protein and mRNA expression downregulation was observed in patients with LDH according to western blotting and reverse transcription‑quantitative polymerase chain reaction. By contrast, upregulation of interleukin‑2 (IL‑2), IL‑6, IL‑8 and tumor necrosis factor‑α (TNF‑α) expression was observed in patients with LDH, according to an enzyme‑linked immunosorbent assay. Mechanical allodynia was observed in rats with LDH not treated with FLL; however, not in FLL‑treated rats. IL‑2, IL‑6, IL‑8 and TNF‑α expression levels in the serum from untreated rats were significantly higher than that of the FLL‑treated rat models. Protein expression levels of MMPs in FLL‑treated rats were lower than those in untreated rats. However, the mechanisms underlying the association between FLL and protein expression levels require further investigation.
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Copy and paste a formatted citation
Spandidos Publications style
Han YX, Liang D, Han XR and Liang DY: Comparative analysis of the influence of Fructus Ligustri Lucidi on a rat lumbar disc herniation model. Mol Med Rep 12: 1225-1232, 2015.
APA
Han, Y., Liang, D., Han, X., & Liang, D. (2015). Comparative analysis of the influence of Fructus Ligustri Lucidi on a rat lumbar disc herniation model. Molecular Medicine Reports, 12, 1225-1232. https://doi.org/10.3892/mmr.2015.3547
MLA
Han, Y., Liang, D., Han, X., Liang, D."Comparative analysis of the influence of Fructus Ligustri Lucidi on a rat lumbar disc herniation model". Molecular Medicine Reports 12.1 (2015): 1225-1232.
Chicago
Han, Y., Liang, D., Han, X., Liang, D."Comparative analysis of the influence of Fructus Ligustri Lucidi on a rat lumbar disc herniation model". Molecular Medicine Reports 12, no. 1 (2015): 1225-1232. https://doi.org/10.3892/mmr.2015.3547
Copy and paste a formatted citation
x
Spandidos Publications style
Han YX, Liang D, Han XR and Liang DY: Comparative analysis of the influence of Fructus Ligustri Lucidi on a rat lumbar disc herniation model. Mol Med Rep 12: 1225-1232, 2015.
APA
Han, Y., Liang, D., Han, X., & Liang, D. (2015). Comparative analysis of the influence of Fructus Ligustri Lucidi on a rat lumbar disc herniation model. Molecular Medicine Reports, 12, 1225-1232. https://doi.org/10.3892/mmr.2015.3547
MLA
Han, Y., Liang, D., Han, X., Liang, D."Comparative analysis of the influence of Fructus Ligustri Lucidi on a rat lumbar disc herniation model". Molecular Medicine Reports 12.1 (2015): 1225-1232.
Chicago
Han, Y., Liang, D., Han, X., Liang, D."Comparative analysis of the influence of Fructus Ligustri Lucidi on a rat lumbar disc herniation model". Molecular Medicine Reports 12, no. 1 (2015): 1225-1232. https://doi.org/10.3892/mmr.2015.3547
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