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Transforming growth factor‑β, insulin‑like growth factor I/insulin‑like growth factor I receptor and vascular endothelial growth factor‑A: Prognostic and predictive markers in triple‑negative and non‑triple‑negative breast cancer

  • Authors:
    • Abeer Bahhnassy
    • Marwa Mohanad
    • Sabry Shaarawy
    • Manal F. Ismail
    • Ahmed El‑Bastawisy
    • Abeer M. Ashmawy
    • Abdel‑Rahman Zekri
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    Affiliations: Molecular Pathology Unit, Pathology Department, National Cancer Institute, Cairo University, Cairo 11796, Egypt, Department of Biochemistry, Faculty of Pharmacy, Misr University for Science and Technology, Cairo 11796, Egypt, Department of Cancer Biology, National Cancer Institute, Cairo University, Cairo 11796, Egypt, Faculty of Pharmacy, Cairo University, Cairo 11796, Egypt, Department of Medical Oncology, National Cancer Institute, Cairo University, Cairo 11796, Egypt
    Copyright: © Bahhnassy et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 851-864
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    Published online on: March 27, 2015
       https://doi.org/10.3892/mmr.2015.3560
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Abstract

In the current study, the prognostic and predictive values of serum transforming growth factor‑β1 (TGF‑β1), insulin‑like growth factor I (IGF‑I)/IGF‑I receptor (IGF‑IR) and vascular endothelial growth factor‑A (VEGF‑A) were evaluated in triple‑negative and non‑triple‑negative breast cancer (TNBC and non‑TNBC). The aim was to identify a group of serological biomarkers and to identify possible candidates for targeted therapy in patients with TNBC and non‑TNBC. Protein levels of TGF‑β1, IGF‑I/IGF‑IR and VEGF‑A in the serum were measured in 43 TNBC, 53 non‑TNBC and 20 normal control participants using quantitative ELISA assays. Results were correlated against standard prognostic factors, response to treatment and survival. TNBC was identified to be associated with poor prognosis and serum levels of VEGF‑A and IGF/IGF‑IR were significantly higher in the TNBC group compared with the non‑TNBC group. IGF‑IR and VEGF‑A overexpression was observed to be correlated with TGF‑β1 expression and all of the markers investigated were associated with metastasis and disease progression. In the multivariate analysis, VEGF‑A, IGF‑I and IGF‑IR were observed to be independent predictors for overall survival, whereas TGF‑β1 and lymph node status were identified as independent predictors for disease‑free survival. The overall response rate was significantly lower in patients with TNBC and those with high levels of TGF‑β1, IGF‑I/IGF‑IR and VEGF‑A. In view of the present results, it was concluded that TGF‑β1, IGF‑I/IGF‑IR and VEGF‑A overexpression is associated with the presence of aggressive tumors, which exhibit an increased probability of metastasis, a poor response to treatment and reduced survival rate. This indicates that VEGF‑A, IGF‑IR and IGF‑I have the potential to be used as surrogate biomarkers and are promising candidates for targeted therapy, particularly in patients with TNBC.
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View References

1 

Siegel R, Ward E, Brawley O and Jemal A: Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 61:212–236. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Litzenburger BC, Creighton CJ, Tsimelzon A, et al: High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy. Clin Cancer Res. 17:2314–2327. 2011. View Article : Google Scholar :

3 

Rakha EA, Reis-Filho JS and Ellis IO: Basal-like breast cancer: a critical review. J Clin Oncol. 26:2568–2581. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Dent R, Trudeau M, Pritchard KI, Hanna WM, Kahn HK, Sawka CA, Lickley LA, Rawlinson E, Sun P and Narod SA: Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res. 13:4429–4434. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Liedtke C, Mazouni C, Hess KR, Andre F, Tordai A, Mejia JA, Symmans WF, Gonzalez-Angulo AM, Hennessy B, Green M, et al: Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J Clin Oncol. 26:1275–1281. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Brouckaert O, Wildiers H, Floris G and Neven P: Update on triple-negative breast cancer: prognosis and management strategies. Int J Womens Health. 4:511–520. 2012.PubMed/NCBI

7 

Cao H, Yan M, Wang S, Zheng T, Xu R, Chen Y and Liu Y: Clinical characteristics and prognosis of triple-negative breast cancer. Chin-Ger J Clin Oncol. 8:471–475. 2009. View Article : Google Scholar

8 

Oakman C, Moretti E, Galardi F, Biagioni C, Santarpia L, Biganzoli L and Di Leo A: Adjuvant systemic treatment for individual patients with triple negative breast cancer. Breast. 20(Suppl 3): S135–S141. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Kashiwagi S, Yashiro M, Takashima T, Nomura S, Noda S, Kawajiri H, Ishikawa T, Wakasa K and Hirakawa K: Significance of E-cadherin expression in triple-negative breast cancer. Br J Cancer. 103:249–255. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Dumont N, Bakin AV and Arteaga CL: Autocrine transforming growth factor-beta signaling mediates Smad-independent motility in human cancer cells. J Biol Chem. 278:3275–3285. 2003. View Article : Google Scholar

11 

Tan AR, Alexe G and Reiss M: Transforming growth factor-beta signaling: emerging stem cell target in metastatic breast cancer? Breast Cancer Res Treat. 115:453–495. 2009. View Article : Google Scholar :

12 

Adams J, Carder PJ, Downey S, Forbes MA, MacLennan K, Allgar V, Kaufman S, Hallam S, Bicknell R, Walker JJ, et al: Vascular endothelial growth factor (VEGF) in breast cancer: comparison of plasma, serum, and tissue VEGF and microvessel density and effects of tamoxifen. Cancer Res. 60:2898–2905. 2000.PubMed/NCBI

13 

George ML, Eccles SA, Tutton MG, Abulafi AM and Swift RI: Correlation of plasma and serum vascular endothelial growth factor levels with platelet count in colorectal cancer: clinical evidence of platelet scavenging? Clin Cancer Res. 6:3147–3152. 2000.PubMed/NCBI

14 

Pollak MN, Schernhammer ES and Hankinson SE: Insulin-like growth factors and neoplasia. Nat Rev Cancer. 4:505–518. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Hankinson SE: Circulating levels of sex steroids and prolactin in premenopausal women and risk of breast cancer. Adv Exp Med Biol. 617:161–169. 2008.PubMed/NCBI

16 

Reiss K, Wang JY, Romano G, Furnari FB, Cavenee WK, Morrione A, Tu X and Baserga R: IGF-I receptor signaling in a prostatic cancer cell line with a PTEN mutation. Oncogene. 19:2687–2694. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Valentinis B, Navarro M, Zanocco-Marani T, Edmonds P, McCormick J, Morrione A, Sacchi A, Romano G, Reiss K and Baserga R: Insulin receptor substrate-1, p70S6K, and cell size in transformation and differentiation of hemopoietic cells. J Biol Chem. 275:25451–25459. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Guerra FK, Eijan AM, Puricelli L, Alonso DF, Bal de Kier Joffé E, Kornblihgtt AR, Charreau EH and Elizalde PV: Varying patterns of expression of insulin-like growth factors I and II and their receptors in murine mammary adenocarcinomas of different metastasizing ability. Int J Cancer. 65:812–820. 1996. View Article : Google Scholar : PubMed/NCBI

19 

Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET and Carbone PP: Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 5:649–655. 1982. View Article : Google Scholar : PubMed/NCBI

20 

Therasse P, Arbuck SG, Eisenhauer EA, et al: New guidelines to evaluate the response to treatment in solid tumors European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 92:205–216. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Iva nović V, To dorović-Ra ković N, D emajo M, Nesković-Konstantinović Z, Subota V, Ivanisević-Milovanović O and Nikolić-Vukosavljević D: Elevated plasma levels of transforming growth factor-beta 1 (TGF-beta 1) in patients with advanced breast cancer: association with disease progression. Eur J Cancer. 39:454–461. 2003. View Article : Google Scholar

22 

Jones C, Nonni AV, Fulford L, Merrett S, Chaggar R, Eusebi V and Lakhani SR: CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation. Br J Cancer. 85:422–427. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, et al: Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci USA. 100:8418–8423. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Wang X, Chao L, Ma G, Chen L, Tian B, Zang Y and Sun J: Increased expression of osteopontin in patients with triple-negative breast cancer. Eur J Clin Invest. 38:438–446. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Sheen-Chen SM, Chen HS, Sheen CW, Eng HL and Chen WJ: Serum levels of transforming growth factor beta1 in patients with breast cancer. Arch Surg. 136:937–940. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Massagué J, Cheifetz S, Laiho M, Ralph DA, Weis FM and Zentella A: Transforming growth factor-beta. Cancer Surv. 12:81–103. 1992.PubMed/NCBI

27 

Reiss M: TGF-beta and cancer. Microbes Infect. 1:1327–1347. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Shipitsin M, Campbell LL, Argani P, Weremowicz S, Bloushtain-Qimron N, Yao J, Nikolskaya T, Serebryiskaya T, Beroukhim R, Hu M, et al: Molecular definition of breast tumor heterogeneity. Cancer Cell. 11:259–273. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Buck M, von der Fecht J and Knabbe C: Antiestrogenic regulation of transforming growth factor beta receptors I and II in human breast cancer cells. Ann NY Acad Sci. 963:140–143. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Kang Y, He W, Tulley S, Gupta GP, Serganova I, Chen CR, Manova-Todorova K, Blasberg R, Gerald WL and Massagué J: Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc Natl Acad Sci USA. 102:13909–13914. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Yin JJ, Selander K, Chirgwin JM, Dallas M, Grubbs BG, Wieser R, Massagué J, Mundy GR and Guise TA: TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J Clin Invest. 103:197–206. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Tang B, Vu M, Booker T, Santner SJ, Miller FR, Anver MR and Wakefield LM: TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression. J Clin Invest. 112:1116–1124. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Kingsley LA, Fournier PG, Chirgwin JM and Guise TA: Molecular biology of bone metastasis. Mol Cancer Ther. 6:2609–2617. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Kareddula A, Zachariah E, Notterman D and Reiss M: Transforming growth factor-b signaling strength determines target gene expression profile in human keratinocytes. J Epithel Biol Pharmaco. 1:40–94. 2008. View Article : Google Scholar

35 

Marrogi AJ, Munshi A, Merogi AJ, Ohadike Y, El-Habashi A, Marrogi OL and Freeman SM: Study of tumor infiltrating lymphocytes and transforming growth factor-beta as prognostic factors in breast carcinoma. Int J Cancer. 74:492–501. 1997. View Article : Google Scholar : PubMed/NCBI

36 

Gorsch SM, Memoli VA, Stukel TA, Gold LI and Arrick BA: Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer. Cancer Res. 52:6949–6952. 1992.PubMed/NCBI

37 

Desruisseau S, Palmari J, Giusti C, Romain S, Martin PM and Berthois Y: Determination of TGFbeta1 protein level in human primary breast cancers and its relationship with survival. Br J Cancer. 94:239–246. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Dave H, Shah M, Trivedi S and Shukla S: Prognostic utility of circulating transforming growth factor beta 1 in breast cancer patients. Int J Biol Markers. 27:53–59. 2012. View Article : Google Scholar

39 

Taha FM, Zeeneldin AA, Helal AM, Gaber AA, Sallam YA, Ramadan H and Moneer MM: Prognostic value of serum vascular endothelial growth factor in Egyptian females with metastatic triple negative breast cancer. Clin Biochem. 42:1420–1426. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Berns EM, Klijn JG, Look MP, et al: Combined vascular endo-thelial growth factor and TP53 status predicts poor response to tamoxifen therapy in estrogen receptor-positive advanced breast cancer. Clin Cancer Res. 9:1253–1258. 2003.PubMed/NCBI

41 

Foekens JA, Peters HA, Grebenchtchikov N, Look MP, Meijer-van Gelder ME, Geurts-Moespot A, van der Kwast TH, Sweep CG and Klijn JG: High tumor levels of vascular endo-thelial growth factor predict poor response to systemic therapy in advanced breast cancer. Cancer Res. 61:5407–5414. 2001.PubMed/NCBI

42 

Greenberg S and Rugo HS: Triple-negative breast cancer: role of antiangiogenic agents. Cancer J. 16:33–38. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Björndahl M, Cao R, Nissen LJ, et al: Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo. Proc Natl Acad Sci USA. 102:15593–15598. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Moschos SJ and Mantzoros CS: The role of the IGF system in cancer: from basic to clinical studies and clinical applications. Oncology. 63:317–332. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Rubin R and Baserga R: Insulin-like growth factor-I receptor. Its role in cell proliferation, apoptosis, and tumorigenicity. Lab Invest. 73:311–331. 1995.PubMed/NCBI

46 

Dunn SE, Kari FW, French J, Leininger JR, Travlos G, Wilson R and Barrett JC: Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res. 57:4667–4672. 1997.PubMed/NCBI

47 

Gooch JL, Van Den Berg CL and Yee D: Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death - proliferative and anti-apoptotic effects. Breast Cancer Res Treat. 56:1–10. 1999. View Article : Google Scholar : PubMed/NCBI

48 

Decensi A, Veronesi U, Miceli R, Johansson H, Mariani L, Camerini T, Di Mauro MG, Cavadini E, De Palo G, Costa A, et al: Relationships between plasma insulin-like growth factor-I and insulin-like growth factor binding protein-3 and second breast cancer risk in a prevention trial of fenretinide. Clin Cancer Res. 9:4722–4729. 2003.PubMed/NCBI

49 

Gail MH, Costantino JP, Bryant J, Croyle R, Freedman L, Helzlsouer K and Vogel V: Weighing the risks and benefits of tamoxifen treatment for preventing breast cancer. J Natl Cancer Inst. 91:1829–1846. 1999. View Article : Google Scholar : PubMed/NCBI

50 

Yarden RI, Wilson MA and Chrysogelos SA: Estrogen suppression of EGFR expression in breast cancer cells: a possible mechanism to modulate growth. J Cell Biochem. 81(Suppl 36): 232–246. 2001. View Article : Google Scholar

51 

Haffner MC, Petridou B, Peyrat JP, Révillion F, Müller-Holzner E, Daxenbichler G, Marth C and Doppler W: Favorable prognostic value of SOCS2 and IGF-I in breast cancer. BMC Cancer. 7:1362007. View Article : Google Scholar : PubMed/NCBI

52 

Shin A, Ren Z, Shu XO, Cai Q, Gao YT and Zheng W: Expression patterns of insulin-like growth factor 1 (IGF-I) and its receptor in mammary tissues and their associations with breast cancer survival. Breast Cancer Res Treat. 105:55–61. 2007. View Article : Google Scholar

53 

Minami CA, Chung DU and Chang HR: Management options in triple-negative breast cancer. Breast Cancer (Auckl). 5:175–199. 2011.

54 

Sarfstein R, Maor S, Reizner N, Abramovitch S and Werner H: Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer. Mol Cell Endocrinol. 252:241–246. 2006. View Article : Google Scholar : PubMed/NCBI

55 

Valentinis B, Romano G, Peruzzi F, Morrione A, Prisco M, Soddu S, Cristofanelli B, Sacchi A and Baserga R: Growth and differentiation signals by the insulin-like growth factor 1 receptor in hemopoietic cells are mediated through different pathways. J Biol Chem. 274:12423–12430. 1999. View Article : Google Scholar : PubMed/NCBI

56 

Munagala R, Aqil F and Gupta RC: Promising molecular targeted therapies in breast cancer. Indian J Pharmacol. 43:236–245. 2011. View Article : Google Scholar : PubMed/NCBI

57 

Shimizu C, Hasegawa T, Tani Y, Takahashi F, Takeuchi M, Watanabe T, Ando M, Katsumata N and Fujiwara Y: Expression of insulin-like growth factor 1 receptor in primary breast cancer: immunohistochemical analysis. Hum Pathol. 35:1537–1542. 2004. View Article : Google Scholar : PubMed/NCBI

58 

Pizon M, Zimon DS, Pachmann U and Pachmann K: Insulin-like growth factor receptor I (IGF-IR) and vascular endothelial growth factor receptor 2 (VEGFR-2) are expressed on the circulating epithelial tumor cells of breast cancer patients. PLoS One. 8:e568362013. View Article : Google Scholar : PubMed/NCBI

59 

Grau AM, Wen W, Ramroopsingh DS, Gao YT, Zi J, Cai Q, Shu XO and Zheng W: Circulating transforming growth factor-beta-1 and breast cancer prognosis: results from the Shanghai Breast Cancer Study. Breast Cancer Res Treat. 112:335–341. 2008. View Article : Google Scholar

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Spandidos Publications style
Bahhnassy A, Mohanad M, Shaarawy S, Ismail MF, El‑Bastawisy A, Ashmawy AM and Zekri AR: Transforming growth factor‑β, insulin‑like growth factor I/insulin‑like growth factor I receptor and vascular endothelial growth factor‑A: Prognostic and predictive markers in triple‑negative and non‑triple‑negative breast cancer. Mol Med Rep 12: 851-864, 2015.
APA
Bahhnassy, A., Mohanad, M., Shaarawy, S., Ismail, M.F., El‑Bastawisy, A., Ashmawy, A.M., & Zekri, A. (2015). Transforming growth factor‑β, insulin‑like growth factor I/insulin‑like growth factor I receptor and vascular endothelial growth factor‑A: Prognostic and predictive markers in triple‑negative and non‑triple‑negative breast cancer. Molecular Medicine Reports, 12, 851-864. https://doi.org/10.3892/mmr.2015.3560
MLA
Bahhnassy, A., Mohanad, M., Shaarawy, S., Ismail, M. F., El‑Bastawisy, A., Ashmawy, A. M., Zekri, A."Transforming growth factor‑β, insulin‑like growth factor I/insulin‑like growth factor I receptor and vascular endothelial growth factor‑A: Prognostic and predictive markers in triple‑negative and non‑triple‑negative breast cancer". Molecular Medicine Reports 12.1 (2015): 851-864.
Chicago
Bahhnassy, A., Mohanad, M., Shaarawy, S., Ismail, M. F., El‑Bastawisy, A., Ashmawy, A. M., Zekri, A."Transforming growth factor‑β, insulin‑like growth factor I/insulin‑like growth factor I receptor and vascular endothelial growth factor‑A: Prognostic and predictive markers in triple‑negative and non‑triple‑negative breast cancer". Molecular Medicine Reports 12, no. 1 (2015): 851-864. https://doi.org/10.3892/mmr.2015.3560
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Spandidos Publications style
Bahhnassy A, Mohanad M, Shaarawy S, Ismail MF, El‑Bastawisy A, Ashmawy AM and Zekri AR: Transforming growth factor‑β, insulin‑like growth factor I/insulin‑like growth factor I receptor and vascular endothelial growth factor‑A: Prognostic and predictive markers in triple‑negative and non‑triple‑negative breast cancer. Mol Med Rep 12: 851-864, 2015.
APA
Bahhnassy, A., Mohanad, M., Shaarawy, S., Ismail, M.F., El‑Bastawisy, A., Ashmawy, A.M., & Zekri, A. (2015). Transforming growth factor‑β, insulin‑like growth factor I/insulin‑like growth factor I receptor and vascular endothelial growth factor‑A: Prognostic and predictive markers in triple‑negative and non‑triple‑negative breast cancer. Molecular Medicine Reports, 12, 851-864. https://doi.org/10.3892/mmr.2015.3560
MLA
Bahhnassy, A., Mohanad, M., Shaarawy, S., Ismail, M. F., El‑Bastawisy, A., Ashmawy, A. M., Zekri, A."Transforming growth factor‑β, insulin‑like growth factor I/insulin‑like growth factor I receptor and vascular endothelial growth factor‑A: Prognostic and predictive markers in triple‑negative and non‑triple‑negative breast cancer". Molecular Medicine Reports 12.1 (2015): 851-864.
Chicago
Bahhnassy, A., Mohanad, M., Shaarawy, S., Ismail, M. F., El‑Bastawisy, A., Ashmawy, A. M., Zekri, A."Transforming growth factor‑β, insulin‑like growth factor I/insulin‑like growth factor I receptor and vascular endothelial growth factor‑A: Prognostic and predictive markers in triple‑negative and non‑triple‑negative breast cancer". Molecular Medicine Reports 12, no. 1 (2015): 851-864. https://doi.org/10.3892/mmr.2015.3560
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