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August-2015 Volume 12 Issue 2

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Article

HOTAIR is a potential target for the treatment of cisplatin‑resistant ovarian cancer

  • Authors:
    • Yu Wang
    • Hongli Wang
    • Tiefang Song
    • Yiting Zou
    • Jing Jiang
    • Lei Fang
    • Peiling Li
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China
  • Pages: 2211-2216
    |
    Published online on: March 27, 2015
       https://doi.org/10.3892/mmr.2015.3562
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Abstract

Previous studies have demonstrated that the presence of Hox transcript antisense intergenic RNA (HOTAIR) is correlated with poor survival in several types of cancer, including breast cancer, and promotes tumor metastasis. Currently, little is known regarding the correlation between HOTAIR and chemoresistance in cancer. The current study aimed to investigate the role of HOTAIR in epithelial ovarian cancer, and the correlation between HOTAIR and cisplatin resistance. Reverse transcription-quantitative polymerase chain reaction was conducted to detect HOTAIR expression in the ovarian specimens and ovarian carcinoma cell lines. The results indicated that the expression level of HOTAIR was higher in epithelial ovarian cancer tissues than the level in the benign ovarian tissues. The expression level was also higher in late‑stage malignant ovarian tumors compared with the level in early‑stage tumors. Levels of HOTAIR were also higher in the SKOV‑3CDDP/R cisplatin‑resistant ovarian carcinoma cell line than in the SKOV‑3 cisplatin‑sensitive cell line. The knockdown of HOTAIR using siRNAs with transfection reagent suppressed cell proliferation, reduced the invasion ability of the cells and notably, it restored cisplatin‑sensitivity of the cisplatin‑resistant cells specifically by enhancing cisplatin‑induced cytotoxicity and apoptosis in SKOV‑3CDDP/R cells. In conclusion, HOTAIR may be used in the development of novel treatments for ovarian cancer, particularly those that are resistant to conventional therapies.
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1 

Jemal A, Thomas A, Murray T and Thun M: Cancer statistics. CA Cancer J Clin. 52:23–47. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Bertone-Johnson ER: Epidemiology of ovarian cancer: a status report. Lancet. 365:101–102. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T and Thun MJ: Cancer statistics, 2008. CA Cancer J Clin. 58:71–96. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Bell DA: Origins and molecular pathology of ovarian cancer. Mod Pathol. 18(Suppl 2): S19–S32. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Sood AK and Buller RE: Drug resistance in ovarian cancer: from the laboratory to the clinic. Obstet Gynecol. 92:312–319. 1998. View Article : Google Scholar : PubMed/NCBI

6 

McGuire WP, Hoskins WJ, Brady MF, et al: Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer. N Engl J Med. 334:1–6. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Mattick JS: The genetic signatures of noncoding RNAs. PLoS Genet. 5:e10004592009. View Article : Google Scholar : PubMed/NCBI

8 

Yasuda J and Hayashizaki Y: The RNA continent. Adv Cancer Res. 99:77–112. 2008.

9 

Ponting CP, Oliver PL and Reik W: Evolution and functions of long noncoding RNAs. Cell. 136:629–641. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Gupta RA, Shah N, Wang KC, Kim J, et al: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 464:1071–1076. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Yang Z, Zhou L, Wu LM, et al: Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepato-cellular carcinoma patients following liver transplantation. Ann Surg Oncol. 18:1243–1250. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Kogo R, Shimamura T, Mimori K, Kawahara K, et al: Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res. 71:6320–6326. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Kim K, Jutooru I, Chadalapaka G, et al: HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene. 32:1616–1625. 2013. View Article : Google Scholar

14 

Liu XH, Liu ZL, Sun M, Liu J, Wang ZX and De W: The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer. BMC Cancer. 13:4642013. View Article : Google Scholar : PubMed/NCBI

15 

Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, et al: Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell. 129:1311–1323. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Gadducci A, Cosio S, Zola P, et al: Surveillance procedures for patients treated for epithelial ovarian cancer: a review of the literature. Int J Gynecol Cancer. 17:21–31. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Godwin AK, Meister A, O’Dwyer PJ, Huang CS, Hamilton TC and Anderson ME: High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis. Proc Natl Acad Sci USA. 89:3070–3074. 1992. View Article : Google Scholar : PubMed/NCBI

18 

Kelley SL, Basu A, Teicher BA, Hacker MP, Hamer DH and Lazo J: Overexpression of metallothionein confers resistance to anticancer drugs. Science. 241:1813–1815. 1998. View Article : Google Scholar

19 

Parker RJ, Eastman A, Bostick-Bruton F and Reed E: Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation. J Clin Invest. 87:772–777. 1991. View Article : Google Scholar : PubMed/NCBI

20 

Stordal BK, Davey MW and Davey RA: Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells. Cancer Chemother Pharmacol. 58:256–265. 2006. View Article : Google Scholar

21 

Pardal R, Clarke MF and Morrison SJ: Applying the principles of stem-cell biology to cancer. Nat Rev Cancer. 3:895–902. 2003. View Article : Google Scholar

22 

Curley MD, Garrett LA, Schorge JO, Foster R and Rueda BR: Evidence for cancer stem cells contributing to the pathogenesis of ovarian cancer. Front Biosci (Landmark Ed). 16:368–392. 2011. View Article : Google Scholar

23 

Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, et al: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 7:444756–760. 2006.

24 

Neuzil J, Stantic M, Zobalova R, Chladova J, Wang X, et al: Tumour-initiating cells vs. cancer ‘stem’ cells and CD133: what’s in the name? Biochem Biophys Res Commun. 355:855–859. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Pasini D, Bracken AP, Hansen JB, Capillo M and Helin K: The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol. 27:3769–3779. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Chen YH, Hung MC and Li LY: EZH2: a pivotal regulator for controlling cell differentiation. Am J Transl Res. 4:364–375. 2012.

27 

Khalil AM, Guttman M, Huarte M, Garber M, et al: Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci USA. 106:11667–11672. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Pádua Alves C, Fonseca AS, Muys BR, et al: Brief report: The lincRNA Hotair is required for epithelial-to-mesenchymal transition and stemness maintenance of cancer cells lines. Stem Cells. 31:2827–2832. 2013. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Wang H, Song T, Zou Y, Jiang J, Fang L and Li P: HOTAIR is a potential target for the treatment of cisplatin‑resistant ovarian cancer. Mol Med Rep 12: 2211-2216, 2015.
APA
Wang, Y., Wang, H., Song, T., Zou, Y., Jiang, J., Fang, L., & Li, P. (2015). HOTAIR is a potential target for the treatment of cisplatin‑resistant ovarian cancer. Molecular Medicine Reports, 12, 2211-2216. https://doi.org/10.3892/mmr.2015.3562
MLA
Wang, Y., Wang, H., Song, T., Zou, Y., Jiang, J., Fang, L., Li, P."HOTAIR is a potential target for the treatment of cisplatin‑resistant ovarian cancer". Molecular Medicine Reports 12.2 (2015): 2211-2216.
Chicago
Wang, Y., Wang, H., Song, T., Zou, Y., Jiang, J., Fang, L., Li, P."HOTAIR is a potential target for the treatment of cisplatin‑resistant ovarian cancer". Molecular Medicine Reports 12, no. 2 (2015): 2211-2216. https://doi.org/10.3892/mmr.2015.3562
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Wang H, Song T, Zou Y, Jiang J, Fang L and Li P: HOTAIR is a potential target for the treatment of cisplatin‑resistant ovarian cancer. Mol Med Rep 12: 2211-2216, 2015.
APA
Wang, Y., Wang, H., Song, T., Zou, Y., Jiang, J., Fang, L., & Li, P. (2015). HOTAIR is a potential target for the treatment of cisplatin‑resistant ovarian cancer. Molecular Medicine Reports, 12, 2211-2216. https://doi.org/10.3892/mmr.2015.3562
MLA
Wang, Y., Wang, H., Song, T., Zou, Y., Jiang, J., Fang, L., Li, P."HOTAIR is a potential target for the treatment of cisplatin‑resistant ovarian cancer". Molecular Medicine Reports 12.2 (2015): 2211-2216.
Chicago
Wang, Y., Wang, H., Song, T., Zou, Y., Jiang, J., Fang, L., Li, P."HOTAIR is a potential target for the treatment of cisplatin‑resistant ovarian cancer". Molecular Medicine Reports 12, no. 2 (2015): 2211-2216. https://doi.org/10.3892/mmr.2015.3562
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