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Article

Resveratrol prevents osteoporosis in ovariectomized rats by regulating microRNA-338-3p

  • Authors:
    • Da‑Wei Guo
    • Ya‑Xin Han
    • Lin Cong
    • Dong Liang
    • Guan‑Jun Tu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
  • Pages: 2098-2106
    |
    Published online on: April 1, 2015
       https://doi.org/10.3892/mmr.2015.3581
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Abstract

Osteoporosis is a disease characterized by loss of bone mass and degeneration of the microstructure of bone. Resveratrol (3,5,4‑tri‑hydroxystilbene; RESV) may delay the onset of a variety of age‑related diseases. In the present study, an ovariectomized female rat model was used to detect the changes in microRNAs (miRNAs/miRs) following RESV treatment. Subsequently, the target genes of miRNA were predicted using TargetScan software and determined using a dual‑luciferase reporter assay. Finally, the role of miR‑338‑3p in the proliferation and differentiation of human osteoblast (HOB) cells was confirmed. The predominant finding of the present study was the identification of an intact mechanism of the effect of RESV in osteoporosis treatment. The results suggested that RESV suppresses miR‑338‑3p, followed by an increase in the expression of runt‑related transcription factor 2 in HOB cells.
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Copy and paste a formatted citation
Spandidos Publications style
Guo DW, Han YX, Cong L, Liang D and Tu GJ: Resveratrol prevents osteoporosis in ovariectomized rats by regulating microRNA-338-3p. Mol Med Rep 12: 2098-2106, 2015.
APA
Guo, D., Han, Y., Cong, L., Liang, D., & Tu, G. (2015). Resveratrol prevents osteoporosis in ovariectomized rats by regulating microRNA-338-3p. Molecular Medicine Reports, 12, 2098-2106. https://doi.org/10.3892/mmr.2015.3581
MLA
Guo, D., Han, Y., Cong, L., Liang, D., Tu, G."Resveratrol prevents osteoporosis in ovariectomized rats by regulating microRNA-338-3p". Molecular Medicine Reports 12.2 (2015): 2098-2106.
Chicago
Guo, D., Han, Y., Cong, L., Liang, D., Tu, G."Resveratrol prevents osteoporosis in ovariectomized rats by regulating microRNA-338-3p". Molecular Medicine Reports 12, no. 2 (2015): 2098-2106. https://doi.org/10.3892/mmr.2015.3581
Copy and paste a formatted citation
x
Spandidos Publications style
Guo DW, Han YX, Cong L, Liang D and Tu GJ: Resveratrol prevents osteoporosis in ovariectomized rats by regulating microRNA-338-3p. Mol Med Rep 12: 2098-2106, 2015.
APA
Guo, D., Han, Y., Cong, L., Liang, D., & Tu, G. (2015). Resveratrol prevents osteoporosis in ovariectomized rats by regulating microRNA-338-3p. Molecular Medicine Reports, 12, 2098-2106. https://doi.org/10.3892/mmr.2015.3581
MLA
Guo, D., Han, Y., Cong, L., Liang, D., Tu, G."Resveratrol prevents osteoporosis in ovariectomized rats by regulating microRNA-338-3p". Molecular Medicine Reports 12.2 (2015): 2098-2106.
Chicago
Guo, D., Han, Y., Cong, L., Liang, D., Tu, G."Resveratrol prevents osteoporosis in ovariectomized rats by regulating microRNA-338-3p". Molecular Medicine Reports 12, no. 2 (2015): 2098-2106. https://doi.org/10.3892/mmr.2015.3581
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