Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2015 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2015 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Analysis of gene expression profiles associated with glioma progression

  • Authors:
    • Guozhang Hu
    • Bo Wei
    • Lina Wang
    • Le Wang
    • Daliang Kong
    • Ying Jin
    • Zhigang Sun
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Neurosurgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Ophthalmology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Opthalmology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Neurology, Jilin Oilfield General Hospital, Songyuan 131200, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1884-1890
    |
    Published online on: April 1, 2015
       https://doi.org/10.3892/mmr.2015.3583
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to investigate changes at the transcript level that are associated with spontaneous astrocytoma progression, and further, to discover novel targets for glioma diagnosis and therapy. GSE4290 microarray data downloaded from Gene Expression Omnibus were used to identify the differentially expressed genes (DGEs) by significant analysis of microarray (SAM). The Short Time Series Expression Miner (STEM) method was then applied to class these DEGs based on their degrees of differentiation in the process of tumor progression. Finally, EnrichNet was used to perform the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis based on a protein‑protein interaction (PPI) network. A total of 4,506 DEGs were detected, and the number of DEGs was the highest in grade IV cells (2,580 DEGs). These DEGs were classified into nine clusters by the STEM method. In total, 11 KEGG pathways with XD‑scores larger than the threshold (0.96) were obtained. The DEGs enriched in pathways 1 (extracellular matrix‑receptor interaction), 3 (phagosome) and 6 (type I diabetes mellitus) mainly belonged to cluster 5. Pathway 2 (long‑term potentiation), 4 (Vibrio cholerae infection) and 5 (epithelial cell signaling in Helicobacter pylori infection) was involved with DEGs that belonged to different clusters. Significant changes in gene expression occurred during glioma progression. Pathways 1, 3 and 6 may be important for the deterioration of glioma into glioblastoma, and pathways 2, 4 and 5 may have a role at each stage during glioma progression. The associated DEGs, including SV2, NMDAR and mGluRs, may be suitable as biomarkers or therapeutic targets for gliomas.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Mamelak AN and Jacoby DB: Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601). Expert Opin Drug Deliv. 4:175–186. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Goebell E, Paustenbach S, Vaeterlein O, et al: Low-grade and anaplastic gliomas: differences in architecture evaluated with diffusion-tensor MR imaging. Radiology. 239:217–222. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Fine HA, Dear KB, Loeffler JS, Black PM and Canellos GP: Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer. 71:2585–2597. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Stark AM, Hugo H, Witzel P, Mihajlovic Z and Mehdorn HM: Age-related expression of p53, Mdm2, EGFR and Msh2 in glioblastoma multiforme. Zentralbl Neurochir. 64:30–36. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Li J, Yen C, Liaw D, et al: PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast and prostate cancer. Science. 275:1943–1947. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Simon M, Köster G, Menon AG and Schramm J: Functional evidence for a role of combined CDKN2A (p16-p14ARF)/CDKN2B (p15) gene inactivation in malignant gliomas. Acta Neuropathol. 98:444–452. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Freije WA, Castro-Vargas FE, Fang Z, et al: Gene expression profiling of gliomas strongly predicts survival. Cancer Res. 64:6503–6510. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Shai R, Shi T, Kremen TJ, et al: Gene expression profiling identifies molecular subtypes of gliomas. Oncogene. 22:4918–4923. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Nutt CL, Mani D, Betensky RA, et al: Gene expression-based classification of malignant gliomas correlates better with survival than histological classification. Cancer Res. 63:1602–1607. 2003.PubMed/NCBI

10 

Sun L, Hui AM, Su Q, et al: Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell. 9:287–300. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Gruber HE, Ingram JA, Hoelscher GL, Zinchenko N, Hanley EN Jr and Sun Y: Asporin, a susceptibility gene in osteoarthritis, is expressed at higher levels in the more degenerate human inter-vertebral disc. Arthritis Res Ther. 11:R472009. View Article : Google Scholar

12 

Larsson O, Wahlestedt C and Timmons JA: Considerations when using the significance analysis of microarrays (SAM) algorithm. BMC Bioinformatics. 6:1292005. View Article : Google Scholar : PubMed/NCBI

13 

Ernst J and Bar-Joseph Z: STEM: a tool for the analysis of short time series gene expression data. BMC Bioinformatics. 7:1912006. View Article : Google Scholar : PubMed/NCBI

14 

Glaab E, Baudot A, Krasnogor N, Schneider R and Valencia A: EnrichNet: network-based gene set enrichment analysis. Bioinformatics. 28:i451–i457. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Szklarczyk D, Franceschini A, Kuhn M, et al: The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res. 39(Database Issue): 561–568. 2011. View Article : Google Scholar

16 

Paulus W and Tonn JC: Interactions of glioma cells and extracellular matrix. J Neurooncol. 24:87–91. 1995. View Article : Google Scholar : PubMed/NCBI

17 

Payne LS and Huang PH: The pathobiology of collagens in glioma. Mol Cancer Res. 11:1129–1140. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Bajjalieh SM, Peterson K, Shinghal R and Scheller RH: SV2, a brain synaptic vesicle protein homologous to bacterial transporters. Science. 257:1271–1273. 1992. View Article : Google Scholar : PubMed/NCBI

19 

Dong M, Yeh F, Tepp WH, et al: SV2 is the protein receptor for botulinum neurotoxin A. Science. 312:592–596. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Crèvecoeur J, Foerch P, Doupagne M, et al: Expression of SV2 isoforms during rodent brain development. BMC Neurosci. 14:872013. View Article : Google Scholar : PubMed/NCBI

21 

de Groot M, Aronica E, Heimans JJ and Reijneveld JC: Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma. Neurology. 77:532–539. 2011. View Article : Google Scholar : PubMed/NCBI

22 

La Torre D, Maugeri R, Angileri FF, et al: Human leukocyte antigen frequency in human high-grade gliomas: a case-control study in Sicily. Neurosurgery. 64:1082–1088. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Guerini FR, Agliardi C, Zanzottera M, et al: Human leukocyte antigen distribution analysis in North Italian brain glioma patients: an association with HLA-DRB1*14. J Neurooncol. 77:213–217. 2006. View Article : Google Scholar

24 

Wiendl H, Mitsdoerffer M, Hofmeister V, et al: A functional role of HLA-G expression in human gliomas: an alternative strategy of immune escape. J Immunol. 168:4772–4780. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Hsieh D, Hsieh A, Stea B and Ellsworth R: IGFBP2 promotes glioma tumor stem cell expansion and survival. Biochem Biophys Res Commun. 397:367–372. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Otani K, Ujike H, Tanaka Y, et al: The GABA type A receptor α5 subunit gene is associated with bipolar I disorder. Neurosci Lett. 381:108–113. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Belelli D, Harrison NL, Maguire J, Macdonald RL, Walker MC and Cope DW: Extrasynaptic GABAA receptors: form, pharmacology and function. J Neurosci. 29:12757–12763. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Smits A, Jin Z, Elsir T, et al: GABA-A channel subunit expression in human glioma correlates with tumor histology and clinical outcome. PLoS One. 7:e370412012. View Article : Google Scholar : PubMed/NCBI

29 

Bliss TV and Collingridge GL: A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 361:31–39. 1993. View Article : Google Scholar : PubMed/NCBI

30 

Dong H, Siu H, Luo L, Fang X, Jin L and Xiong M: Investigation gene and microRNA expression in glioblastoma. BMC Genomics. 11(Suppl 3): 162010. View Article : Google Scholar

31 

Lu YM, Jia Z, Janus C, et al: Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J Neurosci. 17:5196–5205. 1997.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hu G, Wei B, Wang L, Wang L, Kong D, Jin Y and Sun Z: Analysis of gene expression profiles associated with glioma progression. Mol Med Rep 12: 1884-1890, 2015.
APA
Hu, G., Wei, B., Wang, L., Wang, L., Kong, D., Jin, Y., & Sun, Z. (2015). Analysis of gene expression profiles associated with glioma progression. Molecular Medicine Reports, 12, 1884-1890. https://doi.org/10.3892/mmr.2015.3583
MLA
Hu, G., Wei, B., Wang, L., Wang, L., Kong, D., Jin, Y., Sun, Z."Analysis of gene expression profiles associated with glioma progression". Molecular Medicine Reports 12.2 (2015): 1884-1890.
Chicago
Hu, G., Wei, B., Wang, L., Wang, L., Kong, D., Jin, Y., Sun, Z."Analysis of gene expression profiles associated with glioma progression". Molecular Medicine Reports 12, no. 2 (2015): 1884-1890. https://doi.org/10.3892/mmr.2015.3583
Copy and paste a formatted citation
x
Spandidos Publications style
Hu G, Wei B, Wang L, Wang L, Kong D, Jin Y and Sun Z: Analysis of gene expression profiles associated with glioma progression. Mol Med Rep 12: 1884-1890, 2015.
APA
Hu, G., Wei, B., Wang, L., Wang, L., Kong, D., Jin, Y., & Sun, Z. (2015). Analysis of gene expression profiles associated with glioma progression. Molecular Medicine Reports, 12, 1884-1890. https://doi.org/10.3892/mmr.2015.3583
MLA
Hu, G., Wei, B., Wang, L., Wang, L., Kong, D., Jin, Y., Sun, Z."Analysis of gene expression profiles associated with glioma progression". Molecular Medicine Reports 12.2 (2015): 1884-1890.
Chicago
Hu, G., Wei, B., Wang, L., Wang, L., Kong, D., Jin, Y., Sun, Z."Analysis of gene expression profiles associated with glioma progression". Molecular Medicine Reports 12, no. 2 (2015): 1884-1890. https://doi.org/10.3892/mmr.2015.3583
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team