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Meteorin is upregulated in reactive astrocytes and functions as a negative feedback effector in reactive gliosis

  • Authors:
    • Hye Shin Lee
    • Soon‑Hee Lee
    • Jong‑Ho Cha
    • Ji Hae Seo
    • Bum Ju Ahn
    • Kyu‑Won Kim
  • View Affiliations / Copyright

    Affiliations: SNU‑Harvard Neurovascular Protection Research Center, Department of Pharmacy, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151‑742, Republic of Korea
    Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1817-1823
    |
    Published online on: April 14, 2015
       https://doi.org/10.3892/mmr.2015.3610
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Abstract

Reactive gliosis is a glial response to a wide range of central nervous system insults, which results in cellular and molecular changes to resting glial cells. Despite its fundamental effect on neuropathologies, the identification and characterization of the molecular mechanisms underlying this process remain to be fully elucidated. The aim of the present study was to analyze the expression profile and functions of the astrocytic neurotrophic factor, meteorin, in the progression of reactive gliosis. A mouse model of photothrombotic ischemia, and a primary astrocyte culture were used in the present study. Reverse transcription quantitative polymerase chain reaction, western blotting and immunofluorescence staining were performed to examine the expression levels of meteorin and reactive gliosis markers. Increased expression levels of meteorin were observed in reactive astrocytes in a photothrombotic ischemia mouse model, as well as in cultured astrocytes, which were stimulated by transforming growth factor‑β1. Exogenous treatment of the astrocytes with meteorin did not induce janus kinase‑signal transducer and activator of transcription 3 signaling, however, silencing the expression of meteorin in the astrocytes resulted in an upregulation of reactive astrocyte markers, including glial fibrillary acidic protein and S100β, indicating that endogenous meteorin is required for the maintenance of astrocytic homeostasis. These results suggested a novel role for meteorin as a negative feedback effector in reactive gliosis.
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1 

Volterra A and Meldolesi J: Astrocytes, from brain glue to communication elements: The revolution continues. Nat Rev Neurosci. 6:626–640. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Iadecola C and Nedergaard M: Glial regulation of the cerebral microvasculature. Nat Neurosci. 10:1369–1376. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Hamby ME and Sofroniew MV: Reactive astrocytes as therapeutic targets for CNS disorders. Neurotherapeutics. 7:494–506. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Seifert G, Schilling K and Steinhäuser C: Astrocyte dysfunction in neurological disorders: A molecular perspective. Nat Rev Neurosci. 7:194–206. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Abbott NJ, Rönnbäck L and Hansson E: Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci. 7:41–53. 2006. View Article : Google Scholar

6 

Sofroniew MV: Reactive astrocytes in neural repair and protection. Neuroscientist. 11:400–407. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Sofroniew MV: Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 32:638–647. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Silver J and Miller JH: Regeneration beyond the glial scar. Nat Rev Neurosci. 5:146–156. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Di Giorgio FP, Carrasco MA, Siao MC, Maniatis T and Eggan K: Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat Neurosci. 10:608–614. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Nagai M, Re DB, Nagata T, et al: Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci. 10:615–622. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Nishino J, Yamashita K, Hashiguchi H, Fujii H, Shimazaki T and Hamada H: Meteorin: A secreted protein that regulates glial cell differentiation and promotes axonal extension. EMBO J. 23:1998–2008. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Lee HS, Han J, Lee SH, Park JA and Kim KW: Meteorin promotes the formation of GFAP-positive glia via activation of the Jak-STAT3 pathway. J Cell Sci. 123:1959–1968. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Park JA, Lee HS, Ko KJ, et al: Meteorin regulates angiogenesis at the gliovascular interface. Glia. 56:247–258. 2008. View Article : Google Scholar

14 

Tornøe J, Torp M, Jørgensen JR, et al: Encapsulated cell-based biodelivery of meteorin is neuroprotective in the quinolinic acid rat model of neurodegenerative disease. Restor Neurol Neurosci. 30:225–236. 2012.PubMed/NCBI

15 

Jørgensen JR, Xu XJ, Arnold HM, et al: Meteorin reverses hypersensitivity in rat models of neuropathic pain. Exp Neurol. 237:260–266. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Wang Z, Andrade N, Torp M, et al: Meteorin is a chemokinetic factor in neuroblast migration and promotes stroke-induced striatal neurogenesis. J Cereb Blood Flow Metab. 32:387–398. 2012. View Article : Google Scholar :

17 

Jørgensen JR, Thompson L, Fjord-Larsen L, et al: Characterization of Meteorin-an evolutionary conserved neurotrophic factor. J Mol Neurosci. 39:104–116. 2009. View Article : Google Scholar

18 

Cha JH, Wee HJ, Seo JH, et al: AKAP12 mediates barrier functions of fibrotic scars during CNS repair. PLoS One. 9:e946952014. View Article : Google Scholar : PubMed/NCBI

19 

Watson BD, Dietrich WD, Busto R, Wachtel MS and Ginsberg MD: Induction of reproducible brain infarction by photochemically initiated thrombosis. Ann Neurol. 17:497–504. 1985. View Article : Google Scholar : PubMed/NCBI

20 

John GR, Lee SC and Brosnan CF: Cytokines: Powerful regulators of glial cell activation. Neuroscientist. 9:10–22. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Beurrier C, Faideau M, Bennouar KE, et al: Ciliary neurotrophic factor protects striatal neurons against excitotoxicity by enhancing glial glutamate uptake. PLoS One. 5:e85502010. View Article : Google Scholar : PubMed/NCBI

22 

Fang M, He D, Zhang F, et al: Antineuroinflammatory and neurotrophic effects of CNTF and C16 peptide in an acute experimental autoimmune encephalomyelitis rat model. Front Neuroanat. 7:442013. View Article : Google Scholar

23 

Rhee KD, Nusinowitz S, Chao K, Yu F, Bok D and Yang XJ: CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Müller glial cells. Proc Natl Acad Sci USA. 110:E4520–E4529. 2013. View Article : Google Scholar

24 

Bush TG, Puvanachandra N, Horner CH, et al: Leukocyte infiltration, neuronal degeneration and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron. 23:297–308. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Faulkner JR, Herrmann JE, Woo MJ, Tansey KE, Doan NB and Sofroniew MV: Reactive astrocytes protect tissue and preserve function after spinal cord injury. J Neurosci. 24:2143–2155. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lee HS, Lee SH, Cha JH, Seo JH, Ahn BJ and Kim KW: Meteorin is upregulated in reactive astrocytes and functions as a negative feedback effector in reactive gliosis. Mol Med Rep 12: 1817-1823, 2015.
APA
Lee, H.S., Lee, S., Cha, J., Seo, J.H., Ahn, B.J., & Kim, K. (2015). Meteorin is upregulated in reactive astrocytes and functions as a negative feedback effector in reactive gliosis. Molecular Medicine Reports, 12, 1817-1823. https://doi.org/10.3892/mmr.2015.3610
MLA
Lee, H. S., Lee, S., Cha, J., Seo, J. H., Ahn, B. J., Kim, K."Meteorin is upregulated in reactive astrocytes and functions as a negative feedback effector in reactive gliosis". Molecular Medicine Reports 12.2 (2015): 1817-1823.
Chicago
Lee, H. S., Lee, S., Cha, J., Seo, J. H., Ahn, B. J., Kim, K."Meteorin is upregulated in reactive astrocytes and functions as a negative feedback effector in reactive gliosis". Molecular Medicine Reports 12, no. 2 (2015): 1817-1823. https://doi.org/10.3892/mmr.2015.3610
Copy and paste a formatted citation
x
Spandidos Publications style
Lee HS, Lee SH, Cha JH, Seo JH, Ahn BJ and Kim KW: Meteorin is upregulated in reactive astrocytes and functions as a negative feedback effector in reactive gliosis. Mol Med Rep 12: 1817-1823, 2015.
APA
Lee, H.S., Lee, S., Cha, J., Seo, J.H., Ahn, B.J., & Kim, K. (2015). Meteorin is upregulated in reactive astrocytes and functions as a negative feedback effector in reactive gliosis. Molecular Medicine Reports, 12, 1817-1823. https://doi.org/10.3892/mmr.2015.3610
MLA
Lee, H. S., Lee, S., Cha, J., Seo, J. H., Ahn, B. J., Kim, K."Meteorin is upregulated in reactive astrocytes and functions as a negative feedback effector in reactive gliosis". Molecular Medicine Reports 12.2 (2015): 1817-1823.
Chicago
Lee, H. S., Lee, S., Cha, J., Seo, J. H., Ahn, B. J., Kim, K."Meteorin is upregulated in reactive astrocytes and functions as a negative feedback effector in reactive gliosis". Molecular Medicine Reports 12, no. 2 (2015): 1817-1823. https://doi.org/10.3892/mmr.2015.3610
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