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Article

DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells

  • Authors:
    • Xiao‑Lin Zhu
    • Wei Sun
    • Wen‑Bin Lei
    • Hui‑Wen Zhuang
    • Wei‑Jian Hou
    • Wei‑Ping Wen
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China
  • Pages: 2003-2008
    |
    Published online on: April 15, 2015
       https://doi.org/10.3892/mmr.2015.3617
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Abstract

DJ-1, a novel mitogen-dependent oncogene, has an important role in the progression of human malignancies, whereas tumor suppressor phosphatase and tensin homolog (PTEN) is known to control a variety of processes associated with cell survival, proliferation and invasion. DJ‑1 overexpression was reported to be negatively correlated with PTEN expression in tumor tissues of patients with laryngeal squamous cell carcinoma (LSCC). In the present study, the effect of DJ‑1 on PTEN in laryngeal cancer cells was investigated by transfecting DJ‑1‑specific small interfering (si)RNA into Hep‑2 and SNU‑899 cells. Cell survival and cell proliferative and invasive capacity were then evaluated. The results showed that siRNA targeting of DJ‑1 effectively upregulated PTEN expression, resulting in enhanced cell death as well as decreased proliferation and invasion of Hep‑2 and SNU‑899 cells. The results of the present study indicated, for the first time, to the best of our knowledge, that DJ‑1‑induced PTEN downregulation is associated with proliferative and invasive activity of laryngeal cancer cells. The DJ-1 gene may have an important role in the tumorigenesis of LSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu XL, Sun W, Lei WB, Zhuang HW, Hou WJ and Wen WP: DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells. Mol Med Rep 12: 2003-2008, 2015.
APA
Zhu, X., Sun, W., Lei, W., Zhuang, H., Hou, W., & Wen, W. (2015). DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells. Molecular Medicine Reports, 12, 2003-2008. https://doi.org/10.3892/mmr.2015.3617
MLA
Zhu, X., Sun, W., Lei, W., Zhuang, H., Hou, W., Wen, W."DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells". Molecular Medicine Reports 12.2 (2015): 2003-2008.
Chicago
Zhu, X., Sun, W., Lei, W., Zhuang, H., Hou, W., Wen, W."DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells". Molecular Medicine Reports 12, no. 2 (2015): 2003-2008. https://doi.org/10.3892/mmr.2015.3617
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu XL, Sun W, Lei WB, Zhuang HW, Hou WJ and Wen WP: DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells. Mol Med Rep 12: 2003-2008, 2015.
APA
Zhu, X., Sun, W., Lei, W., Zhuang, H., Hou, W., & Wen, W. (2015). DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells. Molecular Medicine Reports, 12, 2003-2008. https://doi.org/10.3892/mmr.2015.3617
MLA
Zhu, X., Sun, W., Lei, W., Zhuang, H., Hou, W., Wen, W."DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells". Molecular Medicine Reports 12.2 (2015): 2003-2008.
Chicago
Zhu, X., Sun, W., Lei, W., Zhuang, H., Hou, W., Wen, W."DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells". Molecular Medicine Reports 12, no. 2 (2015): 2003-2008. https://doi.org/10.3892/mmr.2015.3617
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