|
1
|
Schild L, Dombrowski F, Lendeckel U,
Schulz C, Gardemann A and Keilhoff G: Impairment of endothelial
nitric oxide synthase causes abnormal fat and glycogen deposition
in liver. Biochim Biophys Acta. 1782:180–187. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Schild L, Jaroscakova I, Lendeckel U, Wolf
G and Keilhoff G: Neuronal nitric oxide synthase controls enzyme
activity pattern of mitochondria and lipid metabolism. FASEB J.
20:145–147. 2006.
|
|
3
|
Torregrossa AC, Aranke M and Bryan NS:
Nitric oxide and geriatrics: Implications in diagnostics and
treatment of the elderly. J Geriatr Cardiol. 8:230–242. 2011.
|
|
4
|
Cau SB, Carneiro FS and Tostes RC:
Differential modulation of nitric oxide synthases in aging:
Therapeutic opportunities. Front Physiol. 3:2182012. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Mungrue IN, Gros R, You X, Pirani A, Azad
A, Csont T, Schulz R, Butany J, Stewart DJ and Husain M:
Cardiomyocyte overex-pression of iNOS in mice results in
peroxynitrite generation, heart block, and sudden death. J Clin
Invest. 109:735–743. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Licinio J, Prolo P, McCann SM and Wong ML:
Brain iNOS: Current understanding and clinical implications. Mol
Med Today. 5:225–232. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
van der Loo B, Labugger R, Skepper JN,
Bachschmid M, Kilo J, Powell JM, Palacios-Callender M, Erusalimsky
JD, Quaschning T, Malinski T, et al: Enhanced peroxynitrite
formation is associated with vascular aging. J Exp Med.
192:1731–1744. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Mahbub S, Deburghgraeve CR and Kovacs EJ:
Advanced age impairs macrophage polarization. J Interferon Cytokine
Res. 32:18–26. 2012. View Article : Google Scholar :
|
|
9
|
Bernstein HG, Keilhoff G, Steiner J,
Dobrowolny H and Bogerts B: Nitric oxide and schizophrenia: Present
knowledge and emerging concepts of therapy. CNS Neurol Disord Drug
Targets. 10:792–807. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Keilhoff G: nNOS deficiency-induced cell
proliferation depletes the neurogenic reserve. Neurosci Lett.
505:248–253. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Bian K, Ghassemi F, Sotolongo A, Siu A,
Shauger L, Kots A and Murad F: NOS-2 signaling and cancer therapy.
IUBMB Life. 64:676–683. 2012. View
Article : Google Scholar : PubMed/NCBI
|
|
12
|
Choudhari SK, Chaudhary M, Bagde S,
Gadbail AR and Joshi V: Nitric oxide and cancer: A review. World J
Surg Oncol. 11:1182013. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Fukumura D, Kashiwagi S and Jain RK: The
role of nitric oxide in tumour progression. Nat Rev Cancer.
6:521–534. 2006. View
Article : Google Scholar : PubMed/NCBI
|
|
14
|
Wang Y, Yan W, Lu X, Qian C, Zhang J, Li
P, Shi L, Zhao P, Fu Z, Pu P, et al: Overexpression of osteopontin
induces angiogenesis of endothelial progenitor cells via the
avβ3/PI3K/AKT/eNOS/NO signaling pathway in glioma cells. Eur J Cell
Biol. 90:642–648. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Bulnes S, Argandoña EG, Bengoetxea H, Leis
O, Ortuzar N and Lafuente JV: The role of eNOS in vascular
permeability in ENU-induced gliomas. Acta Neurochir Suppl.
106:277–282. 2010.
|
|
16
|
Lim KH, Ancrile BB, Kashatus DF and
Counter CM: Tumour maintenance is mediated by eNOS. Nature.
452:646–649. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Charles N, Ozawa T, Squatrito M, Bleau AM,
Brennan CW, Hambardzumyan D and Holland EC: Perivascular nitric
oxide activates notch signaling and promotes stem-like character in
PDGF-induced glioma cells. Cell Stem Cell. 6:141–152. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Gratton JP, Lin MI, Yu J, Weiss ED, Jiang
ZL, Fairchild TA, Iwakiri Y, Groszmann R, Claffey KP, Cheng YC, et
al: Selective inhibition of tumor microvascular permeability by
cavtratin blocks tumor progression in mice. Cancer Cell. 4:31–39.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Giliano NY, Konevega LV and Noskin LA:
Dynamics of intracellular superoxide and NO content in human
endotheliocytes and carcinoma cells after treatment with NO
synthase inhibitors. Bull Exp Biol Med. 149:78–81. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Broholm H, Rubin I, Kruse A, Braendstrup
O, Schmidt K, Skriver EB and Lauritzen M: Nitric oxide synthase
expression and enzymatic activity in human brain tumors. Clin
Neuropathol. 22:273–281. 2003.PubMed/NCBI
|
|
21
|
Kostourou V, Cartwright JE, Johnstone AP,
Boult JK, Cullis ER, Whitley G and Robinson SP: The role of
tumour-derived iNOS in tumour progression and angiogenesis. Br J
Cancer. 104:83–90. 2011. View Article : Google Scholar :
|
|
22
|
Lam-Himlin D, Espey MG, Perry G, Smith MA
and Castellani RJ: Malignant glioma progression and nitric oxide.
Neurochem Int. 49:764–768. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Eyler CE, Wu Q, Yan K, MacSwords JM,
Chandler-Militello D, Misuraca KL, Lathia JD, Forrester MT, Lee J,
Stamler JS, et al: Glioma stem cell proliferation and tumor growth
are promoted by nitric oxide synthase-2. Cell. 146:53–66. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Tatemichi M, Ogura T and Esumi H: Impact
of inducible nitric oxide synthase gene on tumor progression. Eur J
Cancer Prev. 18:1–8. 2009. View Article : Google Scholar
|
|
25
|
Kogias E, Osterberg N, Baumer B, Psarras
N, Koentges C, Papazoglou A, Saavedra JE, Keefer LK and Weyerbrock
A: Growth-inhibitory and chemosensitizing effects of the glutathi
one-S-transferase-π-activated nitric oxide donor PABA/NO in
malignant gliomas. Int J Cancer. 130:1184–1194. 2012. View Article : Google Scholar
|
|
26
|
Bian H, Feng J, Li M and Xu W: Novel
antileukemic agents derived from tamibarotene and nitric oxide
donors. Bioorg Med Chem Lett. 21:7025–7029. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Mocellin S, Bronte V and Nitti D: Nitric
oxide, a double edged sword in cancer biology: Searching for
therapeutic opportunities. Med Res Rev. 27:317–352. 2007.
View Article : Google Scholar
|
|
28
|
Cheng H, Wang L, Mollica M, Re AT, Wu S
and Zuo L: Nitric oxide in cancer metastasis. Cancer Lett. 353:1–7.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Stojic J, Hagemann C, Haas S, Herbold C,
Kühnel S, Gerngras S, Roggendorf W, Roosen K and Vince GH:
Expression of matrix metalloproteinases MMP-1, MMP-11 and MMP-19 is
correlated with the WHO-grading of human malignant gliomas.
Neurosci Res. 60:40–49. 2008. View Article : Google Scholar
|
|
30
|
Pullen NA and Fillmore HL: Induction of
matrix metal-loproteinase-1 and glioma cell motility by nitric
oxide. J Neurooncol. 96:201–209. 2010. View Article : Google Scholar
|
|
31
|
Kodama T, Ikeda E, Okada A, Ohtsuka T,
Shimoda M, Shiomi T, Yoshida K, Nakada M, Ohuchi E and Okada Y:
ADAM12 is selectively overexpressed in human glioblastomas and is
associated with glioblastoma cell proliferation and shedding of
heparin-binding epidermal growth factor. Am J Pathol.
165:1743–1753. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Fillmore HL, VanMeter TE and Broaddus WC:
Membrane-type matrix metalloproteinases (MT-MMPs): Expression and
function during glioma invasion. J Neurooncol. 53:187–202. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Van Meter TE, Broaddus WC, Rooprai HK,
Pilkington GJ and Fillmore HL: Induction of membrane-type-1 matrix
metalloproteinase by epidermal growth factor-mediated signaling in
gliomas. Neuro Oncol. 6:188–199. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Albrechtsen R, Kveiborg M, Stautz D,
Vikeså J, Noer JB, Kotzsh A, Nielsen FC, Wewer UM and Fröhlich C:
ADAM12 redistributes and activates MMP-14, resulting in gelatin
degradation, reduced apoptosis and increased tumor growth. J Cell
Sci. 126:4707–4720. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Akool el-S, Kleinert H, Hamada FM, et al:
Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA
by inhibiting the expression of mRNA-stabilizing factor HuR. Mol
Cell Biol. 23:4901–4916. 2003. View Article : Google Scholar :
|
|
36
|
Knipp BS, Ailawadi G, Ford JW, Peterson
DA, Eagleton MJ, Roelofs KJ, Hannawa KK, Deogracias MP, Ji B,
Logsdon C, et al: Increased MMP-9 expression and activity by aortic
smooth muscle cells after nitric oxide synthase inhibition is
associated with increased nuclear factor-kappaB and activator
protein-1 activity. J Surg Res. 116:70–80. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Okamoto T, Gohil K, Finkelstein EI, Bove
P, Akaike T and van der Vliet A: Multiple contributing roles for
NOS2 in LPS-induced acute airway inflammation in mice. Am J Physiol
Lung Cell Mol Physiol. 286:L198–L209. 2004. View Article : Google Scholar
|
|
38
|
Barsoum IB, Hamilton TK, Li X, Cotechini
T, Miles EA, Siemens DR and Graham CH: Hypoxia induces escape from
innate immunity in cancer cells via increased expression of ADAM10:
Role of nitric oxide. Cancer Res. 71:7433–7441. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Jørgensen LH, Jensen CH, Wewer UM and
Schrøder HD: Transgenic overexpression of ADAM12 suppresses muscle
regeneration and aggravates dystrophy in aged mdx mice. Am J
Pathol. 171:1599–1607. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Wever UM, Albrechtsen R and Engvall E:
ADAM12 The long and the short of it. The ADAM Family of Proteases.
Hooper NM and Lendeckel U: 4. Springer, Dordrecht; The Netherlands:
pp. 123–146. 2005
|
|
41
|
White JM: ADAMs: Modulators of cell-cell
and cell-matrix interactions. Curr Opin Cell Biol. 15:598–606.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Fröhlich C, Klitgaard M, Noer JB, Kotzsch
A, Nehammer C, Kronqvist P, Berthelsen J, Blobel C, Kveiborg M,
Albrechtsen R, et al: ADAM12 is expressed in the tumour vasculature
and mediates ectodomain shedding of several membrane-anchored
endothelial proteins. Biochem J. 452:97–109. 2013.PubMed/NCBI
|
|
43
|
Jacobsen J, Visse R, Sørensen HP, Enghild
JJ, Brew K, Wewer UM and Nagase H: Catalytic properties of ADAM12
and its domain deletion mutants. Biochemistry. 47:537–547. 2008.
View Article : Google Scholar
|
|
44
|
Hougaard S, Loechel F, Xu X, Tajima R,
Albrechtsen R and Wewer UM: Trafficking of human ADAM 12-L:
Retention in the trans-Golgi network. Biochem Biophys Res Commun.
275:261–267. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Kurisaki T, Masuda A, Osumi N, Nabeshima Y
and Fujisawa-Sehara A: Spatially- and temporally-restricted
expression of meltrin alpha (ADAM12) and beta (ADAM19) in mouse
embryo. Mech Dev. 73:211–215. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Yagami-Hiromasa T, Sato T, Kurisaki T,
Kamijo K, Nabeshima Y and Fujisawa-Sehara A: A
metalloprotease-disintegrin participating in myoblast fusion.
Nature. 377:652–656. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Bernstein HG, Keilhoff G, Bukowska A,
Ziegeler A, Funke S, Dobrowolny H, Kanakis D, Bogerts B and
Lendeckel U: ADAM (a disintegrin and metalloprotease) 12 is
expressed in rat and human brain and localized to oligodendrocytes.
J Neurosci Res. 75:353–360. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Kanakis D, Lendeckel U, Theodosiou P,
Dobrowolny H, Mawrin C, Keilhoff G, Bukowska A, Dietzmann K,
Bogerts B and Bernstein HG: ADAM 12: A putative marker of
oligodendro-gliomas? Dis Markers. 34:81–91. 2013. View Article : Google Scholar :
|
|
49
|
Huang PL, Dawson TM, Bredt DS, Snyder SH
and Fishman MC: Targeted disruption of the neuronal nitric oxide
synthase gene. Cell. 75:1273–1286. 1993. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Brenman JE, Xia H, Chao DS, Black SM and
Bredt DS: Regulation of neuronal nitric oxide synthase through
alternative transcripts. Dev Neurosci. 19:224–231. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Gödecke A, Decking UK, Ding Z, et al:
Coronary hemodynamics in endothelial NO synthase knockout mice.
Circ Res. 82:186–194. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Corradin SB, Mauël J, Donini SD,
Quattrocchi E and Ricciardi-Castagnoli P: Inducible nitric oxide
synthase activity of cloned murine microglial cells. Glia.
7:255–262. 1993. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Richter-Landsberg C and Heinrich M:
OLN-93: A new permanent oligodendroglia cell line derived from
primary rat brain glial cultures. J Neurosci Res. 45:161–173. 1996.
View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Wex T, Treiber G, Lendeckel U and
Malfertheiner P: A two-step method for the extraction of
high-quality RNA from endoscopic biopsies. Clin Chem Lab Med.
41:1033–1037. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Härdtner C, Mörke C, Walther R, Wolke C
and Lendeckel U: High glucose activates the alternative
ACE2/Ang-(1–7)/Mas and APN/Ang IV/IRAP RAS axes in pancreatic
β-cells. Int J Mol Med. 32:795–804. 2013.
|
|
56
|
Schild L, Reinheckel T, Reiser M, Horn TF,
Wolf G and Augustin W: Nitric oxide produced in rat liver
mitochondria causes oxidative stress and impairment of respiration
after transient hypoxia. FASEB J. 17:2194–2201. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Gilpin BJ, Loechel F, Mattei MG, Engvall
E, Albrechtsen R and Wewer UM: A novel, secreted form of human ADAM
12 (meltrin alpha) provokes myogenesis in vivo. J Biol Chem.
273:157–166. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Kveiborg M, Albrechtsen R, Couchman JR and
Wewer UM: Cellular roles of ADAM12 in health and disease. Int J
Biochem Cell Biol. 40:1685–1702. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Roy R, Wewer UM, Zurakowski D, Pories SE
and Moses MA: ADAM 12 cleaves extracellular matrix proteins and
correlates with cancer status and stage. J Biol Chem.
279:51323–51330. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Roy R, Zurakowski D, Pories S, Moss ML and
Moses MA: Potential of fluorescent metalloproteinase substrates for
cancer detection. Clin Biochem. 44:1434–1439. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Fröhlich C, Albrechtsen R, Dyrskjøt L,
Rudkjaer L, Ørntoft TF and Wewer UM: Molecular profiling of ADAM12
in human bladder cancer. Clin Cancer Res. 12:7359–7368. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Roy R, Rodig S, Bielenberg D, Zurakowski D
and Moses MA: ADAM12 transmembrane and secreted isoforms promote
breast tumor growth: A distinct role for ADAM12-S protein in tumor
metastasis. J Biol Chem. 286:20758–20768. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Ohlig S, Farshi P, Pickhinke U, van den
Boom J, Höing S, Jakuschev S, Hoffmann D, Dreier R, Schöler HR,
Dierker T, et al: Sonic hedgehog shedding results in functional
activation of the solubilized protein. Dev Cell. 20:764–774. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Pögün S and Kuhar MJ: Regulation of
neurotransmitter reuptake by nitric oxide. Ann NY Acad Sci.
738:305–315. 1994.PubMed/NCBI
|
|
65
|
Boehning D and Snyder SH: Novel neural
modulators. Annu Rev Neurosci. 26:105–131. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Mukherjee P, Cinelli MA, Kang S and
Silverman RB: Development of nitric oxide synthase inhibitors for
neurodegeneration and neuropathic pain. Chem Soc Rev. 43:6814–6838.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Pepicelli O, Brescia A, Gherzi E, Raiteri
M and Fedele E: GABA(A), but not NMDA, receptors modulate in vivo
NO-mediated cGMP synthesis in the rat cerebral cortex.
Neuropharmacology. 46:480–489. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Bernstein HG, Keilhoff G, Seidel B,
Stanarius A, Huang PL, Fishman MC, Reiser M, Bogerts B and Wolf G:
Expression of hypothalamic peptides in mice lacking neuronal nitric
oxide synthase: Reduced beta-END immunoreactivity in the arcuate
nucleus. Neuroendocrinology. 68:403–411. 1998. View Article : Google Scholar
|
|
69
|
Bredt DS and Snyder SH: Nitric oxide, a
novel neuronal messenger. Neuron. 8:3–11. 1992. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Nathan C and Xie QW: Regulation of
biosynthesis of nitric oxide. J Biol Chem. 269:13725–13728.
1994.PubMed/NCBI
|
|
71
|
Gross SS and Wolin MS: Nitric oxide:
Pathophysiological mechanisms. Annu Rev Physiol. 57:737–769. 1995.
View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Blaise GA, Gauvin D, Gangal M and Authier
S: Nitric oxide, cell signaling and cell death. Toxicology.
208:177–192. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Pou S, Keaton L, Surichamorn W and Rosen
GM: Mechanism of superoxide generation by neuronal nitric-oxide
synthase. J Biol Chem. 274:9573–9580. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Yanik M, Vural H, Tutkun H, Zoroğlu SS,
Savaş HA, Herken H, Koçyiğit A, Keleş H and Akyol O: The role of
the arginine-nitric oxide pathway in the pathogenesis of bipolar
affective disorder. Eur Arch Psychiatry Clin Neurosci. 254:43–47.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Jung J, Na C and Huh Y: Alterations in
nitric oxide synthase in the aged CNS. Oxid Med Cell Longev.
2012:7189762012. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Gibbs SM: Regulation of neuronal
proliferation and differentiation by nitric oxide. Mol Neurobiol.
27:107–120. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Dyczynska E, Sun D, Yi H, Sehara-Fujisawa
A, Blobel CP and Zolkiewska A: Proteolytic processing of delta-like
1 by ADAM proteases. J Biol Chem. 282:436–444. 2007. View Article : Google Scholar
|
|
78
|
Chang AC, Fu Y, Garside VC, Niessen K,
Chang L, Fuller M, Setiadi A, Smrz J, Kyle A, Minchinton A, et al:
Notch initiates the endothelial-to-mesenchymal transition in the
atrioventricular canal through autocrine activation of soluble
guanylyl cyclase. Dev Cell. 21:288–300. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Pei H, Yu Q, Xue Q, Guo Y, Sun L, Hong Z,
Han H, Gao E, Qu Y and Tao L: Notch1 cardioprotection in myocardial
ischemia/reperfusion involves reduction of oxidative/nitrative
stress. Basic Res Cardiol. 108:3732013. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Li H, Solomon E, Duhachek Muggy S, Sun D
and Zolkiewska A: Metalloprotease-disintegrin ADAM12 expression is
regulated by Notch signaling via microRNA-29. J Biol Chem.
286:21500–21510. 2011. View Article : Google Scholar : PubMed/NCBI
|
