Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2015 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2015 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Bone marrow-derived mesenchymal stem cells attenuate acute liver injury and regulate the expression of fibrinogen-like-protein 1 and signal transducer and activator of transcription 3

  • Authors:
    • Zhuolin Zou
    • Yijing Cai
    • Yi Chen
    • Si Chen
    • Liyuan Liu
    • Zhonghai Shen
    • Sainan Zhang
    • Lanman Xu
    • Yongping Chen
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Disease, Wenzhou Key Laboratory of Hepatology, Hepatology Institute of Wenzhou Medical University, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Orthopedic Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China
  • Pages: 2089-2097
    |
    Published online on: April 22, 2015
       https://doi.org/10.3892/mmr.2015.3660
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In recent years, bone marrow-derived mesenchymal stem cells (BMSCs) have been demonstrated to exert extensive therapeutic effects on acute liver injury; however, the underlying mechanisms of these effects have remained to be elucidated. The present study focused on the potential anti‑apoptotic and pro‑regenerative effects of BMSCs in D‑galactosamine (D‑Gal) and lipopolysaccharide (LPS)‑induced acute liver injury in rats. An experimental rat acute liver injury model was established by intraperitoneal injection of D‑Gal (400 mg/kg) and LPS (80 µg/kg). BMSCs and an identical volume of saline were administered via the caudal vein 2 h after the D‑Gal and LPS challenge. Subsequently, the serum samples were collected to detect the levels of alanine aminotransferase and aspartate aminotransferase. Hematoxylin and eosin staining, terminal deoxynucleotidyl transferase‑mediated nick‑end labeling assay and immunohistochemical staining were performed to determine apoptosis, regeneration and histological changes of liver sections. Western blotting and reverse transcription‑quantitative polymerase chain reaction were performed to detect the protein and mRNA expression levels of fibrinogen‑like‑protein 1 (FGL1), phosphorylated signal transducer and activator of transcription 3 (p‑STAT3), STAT3 and B‑cell lymphoma 2 (Bcl‑2) and Bcl‑2 associated X protein (Bax) in liver tissue samples. The results indicated that intravenous transplantation of BMSCs significantly decreased the levels of alanine aminotransferase and aspartate aminotransferase, and reduced hepatocellular necrosis and inflammatory cell infiltration. Additionally, a terminal deoxynucleotidyl transferase‑mediated nick‑end labeling assay and immunohistochemical staining revealed that BMSC treatment reduced hepatocyte apoptosis and enhanced liver regeneration. Furthermore, Bcl‑2 expression was increased, whilst the protein expression of Bax was reduced. The expression of FGL1 and p‑STAT3 were elevated concurrently with the improvement of liver function. These results demonstrated that BMSCs may provide a promising potential agent for the prevention of acute liver injury via inhibition of hepatocyte apoptosis and acceleration of liver regeneration. The mechanism may be, a least in part, a consequence of the upregulation of FGL1 expression and the induction of STAT3 phosphorylation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Gitto S, Micco L, Conti F, Andreone P and Bernardi M: Alcohol and viral hepatitis: a mini-review. Dig Liver Dis. 41:67–70. 2009. View Article : Google Scholar

2 

Leise MD, Poterucha JJ and Talwalkar JA: Drug-induced liver injury. Mayo Clin Proc. 89:95–106. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Bernal W and Wendon J: Acute liver failure. N Engl J Med. 369:2525–2534. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Rai R: Liver transplantatation- an overview. Indian J Surg. 75:185–191. 2013. View Article : Google Scholar :

5 

Åberg F, Isoniemi H and Höckerstedt K: Long-term results of liver transplantation. Scand J Surg. 100:14–21. 2011.PubMed/NCBI

6 

Esrefoglu M: Role of stem cells in repair of liver injury: experimental and clinical benefit of transferred stem cells on liver failure. World J Gastroenterol. 19:6757–6773. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Wesson RN and Cameron AM: Stem cells in acute liver failure. Adv Surg. 45:117–130. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Reis LA, Borges FT, Simões MJ, Borges AA, Sinigaglia-Coimbra R and Schor N: Bone marrow-derived mesenchymal stem cells repaired but did not prevent gentamicin-induced acute kidney injury through paracrine effects in rats. PloS One. 7:e440922012. View Article : Google Scholar : PubMed/NCBI

9 

Cai B, Zhu S, Li J, Chen N, Liu Y and Lu Y: Bone marrow-derived mesenchymal stem cells protected rat cardiomyocytes from premature senescence. Int J Cardiol. 154:180–182. 2012. View Article : Google Scholar

10 

van Haaften T, Byrne R, Bonnet S, et al: Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats. Am J Respir Crit Care Med. 180:1131–1142. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Wang SP, Wang ZH, Peng DY, Li SM, Wang H and Wang XH: Therapeutic effect of mesenchymal stem cells in rats with intracerebral hemorrhage: Reduced apoptosis and enhanced neuroprotection. Mol Med Rep. 6:848–854. 2012.PubMed/NCBI

12 

Han Y, Lan N, Pang C and Tong X: Bone marrow-derived mesenchymal stem cells enhance cryopreserved trachea allograft epithelium regeneration and vascular endothelial growth factor expression. Transplantation. 92:620–626. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Gabrielyan A, Knaak S, Gelinsky M, Arnhold S and Rösen-Wolff A: Hypoxia-conditioned media allows species-specific attraction of bone marrow stromal cells without need for recombinant proteins. BMC Vet Res. 10:562014. View Article : Google Scholar : PubMed/NCBI

14 

Seyfried DM, Han Y, Yang D, et al: Localization of bone marrow stromal cells to the injury site after intracerebral hemorrhage in rats. J Neurosurg. 112:329–335. 2010. View Article : Google Scholar :

15 

Xu YQ and Liu ZC: Therapeutic potential of adult bone marrow stem cells in liver disease and delivery approaches. Stem Cell Rev. 4:101–112. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Mezey E: The therapeutic potential of bone marrow-derived stromal cells. J Cell Biochem. 112:2683–2687. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Meirelles Lda S, Fontes AM, Covas DT and Caplan AI: Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev. 20:419–427. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Uccelli A, Moretta L and Pistoia V: Mesenchymal stem cells in health and disease. Nat Rev Immunol. 8:726–736. 2008. View Article : Google Scholar

19 

Xagorari A, Siotou E, Yiangou M, et al: Protective effect of mesenchymal stem cell-conditioned medium on hepatic cell apoptosis after acute liver injury. Int J Clin Exp Pathol. 6:831–840. 2013.PubMed/NCBI

20 

Yamamoto T, Gotoh M, Sasaki H, Terada M, Kitajima M and Hirohashi S: Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1. Biochem Biophys Res Commun. 193:681–687. 1993. View Article : Google Scholar : PubMed/NCBI

21 

Cao MM, Xu WX, Li CY, et al: Hepassocin regulates cell proliferation of the human hepatic cells L02 and hepatocarcinoma cells through different mechanisms. J Cell Biochem. 112:2882–2890. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Li CY, Cao CZ, Xu WX, et al: Recombinant human hepassocin stimulates proliferation of hepatocytes in vivo and improves survival in rats with fulminant hepatic failure. Gut. 59:817–826. 2010. View Article : Google Scholar

23 

Yan J, Ying H, Gu F, et al: Cloning and characterization of a mouse liver-specific gene mfrep-1, up-regulated in liver regeneration. Cell Res. 12:353–361. 2002. View Article : Google Scholar

24 

Chang YP, Hong HP, Lee YH and Liu IH: The canine epiphyseal-derived mesenchymal stem cells are comparable to bone marrow derived-mesenchymal stem cells. J Vet Med Sci. Nov 12–2014.Epub ahead of print. PubMed/NCBI

25 

Zhu X, Tan T, Yao W, et al: Optimization of the method for isolating and culturing rat mesenchymal stem cells. Nan Fang Yi Ke Da Xue Xue Bao. 34:1621–1626. 2014.In Chinese.

26 

Derveaux S, Vandesompele J and Hellemans J: How to do successful gene expression analysis using real-time PCR. Methods. 50:227–230. 2010. View Article : Google Scholar

27 

Rujiter JM, Pfaffl MW, Zhao S, et al: Evaluation of qPCR curve analysis methods for reliable biomarker discovery: Bias, resolution, precision, and implications. Methods. 59:32–46. 2013. View Article : Google Scholar

28 

Huang SN, Chen TC, Tsai SL and Liaw YF: Histopathology and pathobiology of hepatotropic virus-induced liver injury. J Gastroenterol Hepatol. 12:S195–S217. 1997. View Article : Google Scholar

29 

Teplova VV, Belosludtsev KN, Belosludtseva NV and Kholmukhamedov EL: Mitochondria and hepatotoxicity of ethanol. Biofizika. 55:1038–1047. 2010.In Russian.

30 

Lopez AM and Hendrickson RG: Toxin-induced hepatic injury. Emerg Med Clin North Am. 32:103–125. 2014. View Article : Google Scholar

31 

Kaplowitz N: Biochemical and cellular mechanisms of toxic liver injury. Semin Liver Dis. 22:137–144. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Muntané J, González R, Ranchal I, Collado JA, López-Sánchez LM, Herencia C, Rodríguez-Ariza A, Rafael Muñoz-Castañeda JR and de la Mata M: Mechanisms of liver cell injury. Rev Esp Enferm Dig. 99:405–410. 2007.In Spanish.

33 

Galun E and Axelrod JH: The role of cytokines in liver failure and regeneration: potential new molecular therapies. Biochim Biophys Acta. 1592:345–358. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Chen XW, Zhu DJ, Ju YL and Zhou SF: Therapeutic effect of transplanting magnetically labeled bone marrow stromal stem cells in a liver injury rat model with 70%-hepatectomy. Med Sci Monit. 18:BR375–BR382. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Sun K, Xie X, Xie J, et al: Cell-based therapy for acute and chronic liver failures: Distinct diseases, different choices. Sci Rep. 4:64942014. View Article : Google Scholar : PubMed/NCBI

36 

Hang HL and Xia Q: Role of BMSCs in liver regeneration and metastasis after hepatectomy. World J Gastroenterol. 20:126–132. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Li J, Zhang L, Xin J, et al: Immediate intraportal transplantation of human bone marrow mesenchymal stem cells prevents death from fulminant hepatic failure in pigs. Hepatology. 56:1044–1052. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Yuan S, Jiang T, Sun L, Zheng R, Ahat N and Zhang Y: The role of bone marrow mesenchymal stem cells in the treatment of acute liver failure. Biomed Res Int. 2013:2518462013. View Article : Google Scholar : PubMed/NCBI

39 

Zhu X, He B, Zhou X and Ren J: Effects of transplanted bone-marrow-derived mesenchymal stem cells in animal models of acute hepatitis. Cell Tissue Res. 351:477–486. 2013. View Article : Google Scholar

40 

Ozaki M: Role of jak/STAT3 and PI3-K/Akt pathways in liver injury and regeneration. Seikagaku. 80:399–408. 2008.In Japanese. PubMed/NCBI

41 

Li M, Zhou X, Mei J, et al: Study on the activity of the signaling pathways regulating hepatocytes from G0 phase into G1 phase during rat liver regeneration. Cell Mol Biol Lett. 19:181–200. 2014. View Article : Google Scholar : PubMed/NCBI

42 

da Silva CG, Studer P, Skroch M, et al: A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals. Hepatology. 57:2014–2025. 2013. View Article : Google Scholar :

43 

Lou LX, Uemura T, Mani H, et al: Endogenous signal transducer and activator of transcription 3 is required for the protection of hepatocytes against warm ischemia/reperfusion injury. Liver Transpl. 19:1078–1087. 2013.PubMed/NCBI

44 

Li W, Liang X, Kellendonk C, Poli V and Taub R: STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration. J Biol Chem. 277:28411–28417. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Liu Z and Ukomadu C: Fibrinogen-like protein 1, a hepatocyte derived protein is an acute phase reactant. Biochem Biophys Res Commun. 365:729–734. 2008. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zou Z, Cai Y, Chen Y, Chen S, Liu L, Shen Z, Zhang S, Xu L and Chen Y: Bone marrow-derived mesenchymal stem cells attenuate acute liver injury and regulate the expression of fibrinogen-like-protein 1 and signal transducer and activator of transcription 3. Mol Med Rep 12: 2089-2097, 2015.
APA
Zou, Z., Cai, Y., Chen, Y., Chen, S., Liu, L., Shen, Z. ... Chen, Y. (2015). Bone marrow-derived mesenchymal stem cells attenuate acute liver injury and regulate the expression of fibrinogen-like-protein 1 and signal transducer and activator of transcription 3. Molecular Medicine Reports, 12, 2089-2097. https://doi.org/10.3892/mmr.2015.3660
MLA
Zou, Z., Cai, Y., Chen, Y., Chen, S., Liu, L., Shen, Z., Zhang, S., Xu, L., Chen, Y."Bone marrow-derived mesenchymal stem cells attenuate acute liver injury and regulate the expression of fibrinogen-like-protein 1 and signal transducer and activator of transcription 3". Molecular Medicine Reports 12.2 (2015): 2089-2097.
Chicago
Zou, Z., Cai, Y., Chen, Y., Chen, S., Liu, L., Shen, Z., Zhang, S., Xu, L., Chen, Y."Bone marrow-derived mesenchymal stem cells attenuate acute liver injury and regulate the expression of fibrinogen-like-protein 1 and signal transducer and activator of transcription 3". Molecular Medicine Reports 12, no. 2 (2015): 2089-2097. https://doi.org/10.3892/mmr.2015.3660
Copy and paste a formatted citation
x
Spandidos Publications style
Zou Z, Cai Y, Chen Y, Chen S, Liu L, Shen Z, Zhang S, Xu L and Chen Y: Bone marrow-derived mesenchymal stem cells attenuate acute liver injury and regulate the expression of fibrinogen-like-protein 1 and signal transducer and activator of transcription 3. Mol Med Rep 12: 2089-2097, 2015.
APA
Zou, Z., Cai, Y., Chen, Y., Chen, S., Liu, L., Shen, Z. ... Chen, Y. (2015). Bone marrow-derived mesenchymal stem cells attenuate acute liver injury and regulate the expression of fibrinogen-like-protein 1 and signal transducer and activator of transcription 3. Molecular Medicine Reports, 12, 2089-2097. https://doi.org/10.3892/mmr.2015.3660
MLA
Zou, Z., Cai, Y., Chen, Y., Chen, S., Liu, L., Shen, Z., Zhang, S., Xu, L., Chen, Y."Bone marrow-derived mesenchymal stem cells attenuate acute liver injury and regulate the expression of fibrinogen-like-protein 1 and signal transducer and activator of transcription 3". Molecular Medicine Reports 12.2 (2015): 2089-2097.
Chicago
Zou, Z., Cai, Y., Chen, Y., Chen, S., Liu, L., Shen, Z., Zhang, S., Xu, L., Chen, Y."Bone marrow-derived mesenchymal stem cells attenuate acute liver injury and regulate the expression of fibrinogen-like-protein 1 and signal transducer and activator of transcription 3". Molecular Medicine Reports 12, no. 2 (2015): 2089-2097. https://doi.org/10.3892/mmr.2015.3660
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team