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Article

Characteristics of dendroaspis natriuretic peptide and its receptor in streptozotocin‑induced diabetic rats

  • Authors:
    • Byoung Hyun Park
    • Sun Young Kim
    • Soo Mi Kim
    • Hye Jung Noh
    • Chong Gu Cho
    • Sung Zoo Kim
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Medical School, Wonkwang University, Iksan, Jeonbuk 570‑749, Republic of Korea, Department of Physiology, Medical School, Institute for Medical Sciences, Chonbuk National University, Jeonju, Jeonbuk 561‑180, Republic of Korea
  • Pages: 2969-2976
    |
    Published online on: April 24, 2015
       https://doi.org/10.3892/mmr.2015.3678
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Abstract

Dendroaspis natriuretic peptide (DNP) shares a functionally important sequence homology with other natriuretic peptides. However, the characteristics of DNP and its receptor in the context of diabetes remafin to be fully elucidated. In the present study, alterations in the plasma levels and tissue contents of DNP and the properties of its receptor in diabetic rats, induced by streptozotocin (STZ) injection, were investigated. The plasma levels of DNP were 90.01±4.12 and 196.68±5.60 pg/ml in the control and STZ‑induced diabetic rats, respectively. The tissue contents of DNP in the cardiac atrium, ventricle, renal cortex and inner medulla of the STZ‑induced diabetic rats were also significantly increased compared with the control rats. Specific 125I‑DNP‑binding sites were located predominantly in the glomeruli and inner medulla of the rat kidney. In the glomeruli of the kidney, the apparent dissociation constants (Kd) of 125I‑DNP in the control and STZ‑induced diabetic rats were 0.41±0.03 and 0.56±0.06 nM, respectively. The maximum binding capacities (Bmax) of 125I‑DNP in control and STZ‑induced diabetic rats were 2.98±0.21 and 6.22±1.06 fmol/mg protein, respectively. However, no differences were observed in the apparent Kd and Bmax of 125I‑DNP in the inner medulla of the kidney between the control and STZ‑induced diabetic rats. In the glomerular and inner medullary kidney membranes, DNP stimulated the production of cyclic guanosine monophosphate (cGMP) in a dose‑dependent manner. The magnitude of cGMP production in glomerular membranes was greater in the STZ‑induced diabetic rats, whereas the magnitude of cGMP production in the inner medullary membranes was lower in the STZ‑induced diabetic rats compared with the control rats. These results indicated that STZ‑induced diabetes modulate DNP and its receptor, and also suggested that modulation of the DNP system is involved in the renal function of diabetic animals via the intracellular domain of the kidney NP receptor.
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1 

Schweitz H, Vigne P, Moinier D, Frelin C and Lazdunski M: A new member of the natriuretic peptide family is present in the venom of the green mamba (Dendroaspis angusticeps). J Biol Chem. 267:13928–13932. 1992.PubMed/NCBI

2 

Schirger JA, Heublein DM, Chen HH, et al: Presence of Dendroaspis natriuretic peptide-like immunoreactivity in human plasma and its increase during human heart failure. Mayo Clin Proc. 74:126–130. 1999. View Article : Google Scholar : PubMed/NCBI

3 

Lisy O, Lainchbury JG, Leskinen H and Burnett JC Jr: Therapeutic actions of a new synthetic vasoactive and natriuretic peptide, dendroaspis natriuretic peptide, in experimental severe congestive heart failure. Hypertension. 37:1089–1094. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Woodard GE, Rosado JA and Brown J: Dendroaspis natriuretic peptide-like immunoreactivity and its regulation in rat aortic vascular smooth muscle. Peptides. 23:23–29. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Chen HH, Lainchbury JG and Burnett JC: Natriuretic peptide receptors and neutral endopeptidase in mediating the renal actions of a new therapeutic synthetic natriuretic peptide dendroaspis natriuretic peptide. J Am Coll Cardiol. 40:1186–1191. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Lainchbury JG, Lisy O, Burnett JC Jr, Meyer DM and Redfield MM: Actions of a novel synthetic natriuretic peptide on hemodynamics and ventricular function in the dog. Am J Physiol. 282:R993–R998. 2002.

7 

Singh G, Kuc RE, Maguire JJ, Fidock M and Davenport AP: Novel snake venom ligand dendroaspis natriuretic peptide is selective for natriuretic peptide receptor-A in human heart: downregulation of natriuretic peptide receptor-A in heart failure. Circ Res. 99:183–190. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Kim SM, Kim YA, Kim SY, Kim SH, Cho KW and Kim SZ: Presence of dendroaspis natriuretic peptide and its binding to NPR-A receptor in rabbit kidney. Regulatory peptides. 167:42–49. 2011. View Article : Google Scholar

9 

Kim SM, Kim SY, Kim SH, Cho KW and Kim SZ: Renal actions of dendroaspis natriuretic peptide in rabbits. Peptides. 33:59–66. 2012. View Article : Google Scholar

10 

Kim SM, Kim SY, Kim SH and Kim SZ: Dendroaspis natriuretic peptide is degraded by a metalloproteinase in the rat kidney. Mol Med Rep. 9:1037–1043. 2014.

11 

Dronavalli S, Duka I and Bakris GL: The pathogenesis of diabetic nepthropathy. Nat Clin Pract Endocrinol Metab. 4:444–452. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Walther T, Heringer-Walther S, Tschope R, Reinecke A, Schultheiss HP and Tschope C: Opposite regulation of brain and C-type natriuretic peptides in the streptozotocin-diabetic cardiopathy. J Mol Endocrinol. 24:391–395. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Obineche EN, Adeghate E, Chandranath IS, Benedict S, Al Gafri LS and Adem A: Alterations in atrial natriuretic peptide and its receptors in streptozotocin-induced diabetic rat kidneys. Mol Cell Biochem. 261:3–8. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Ortola FV, Ballermann BJ, Anderson S, Mendez RE and Brenner BM: Elevated plasma atrial natriuretic peptide levels in diabetic rats. Potential mediator of hyperfiltration. J Clin Invest. 80:670–674. 1987. View Article : Google Scholar : PubMed/NCBI

15 

Jacobs EM, Vervoort G, Branten AJ, Klasen I, Smits P and Wetzels JF: Atrial natriuretic peptide increases albuminuria in type I diabetic patients: evidence for blockade of tubular protein reabsorption. Eur J Clin Invest. 29:109–115. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Sawicki PT, Heinemann L, Rave K, Hohmann A and Berger M: Atrial natriuretic factor in various stages of diabetic nephropathy. J Diabet Complications. 2:207–209. 1988. View Article : Google Scholar : PubMed/NCBI

17 

Benigni A, Perico N, Dadan J, et al: Functional implications of decreased renal cortical atrial natriuretic peptide binding in experimental diabetes. Circ Res. 66:1453–1460. 1990. View Article : Google Scholar : PubMed/NCBI

18 

Sechi LA, Valentin JP, Griffin CA, et al: Receptors for atrial natriuretic peptide are decreased in the kidney of rats with streptozotocin-induced diabetes mellitus. J Clin Invest. 95:2451–2457. 1995. View Article : Google Scholar : PubMed/NCBI

19 

Christoffersen C, Bartels ED and Nielsen LB: Heart specific up-regulation of genes for B-type and C-type natriuretic peptide receptors in diabetic mice. European journal of clinical investigation. 36:69–75. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Cho KW, Kim SH, Kim CH and Seul KH: Mechanical basis of ANP secretion in beating atria: atrial stroke volume and ECF translocation. Am J Physiol. 268:R1129–R1136. 1995.PubMed/NCBI

21 

Kim SZ, Cho KW and Kim SH: Modulation of endocardial natriuretic peptide receptors in right ventricular hypertrophy. Am J Physiol. 277:H2280–H2289. 1999.PubMed/NCBI

22 

Kim SZ, Kim SH, Park JK, Koh GY and Cho KW: Presence and biological activity of C-type natriuretic peptide-dependent guanylate cyclase-coupled receptor in the penile corpus cavernosum. J Urol. 159:1741–1746. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Munson PJ and Rodbard D: Ligand: a versatile computerized approach for characterization of ligand-binding systems. Anal Biochem. 107:220–239. 1980. View Article : Google Scholar : PubMed/NCBI

24 

Wu YS, Lu HL, Huang X, Liu DH, Meng XM, Guo X, Kim YC and Xu WX: Diabetes-induced loss of gastric ICC accompanied by up-regulation of natriuretic peptide signaling pathways in STZ-induced diabetic mice. Peptides. 40:104–111. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Wu SQ, Kwan CY and Tang F: Streptozotocin-induced diabetes has differential effects on atrial natriuretic peptide synthesis in the rat atrium and ventricle: a study by solution-hybridization-RNase protection assay. Diabetologia. 41:660–665. 1998. View Article : Google Scholar : PubMed/NCBI

26 

Bai GY, Piao FL, Kim SY, Yuan K, Kim SZ and Kim SH: Augmentation of insulin-stimulated ANP release through tyrosine kinase and PI 3-kinase in diabetic rats. Peptides. 27:2756–2763. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Chinkers M, Garbers DL, Chang MS, et al: A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor. Nature. 338:78–83. 1989. View Article : Google Scholar : PubMed/NCBI

28 

Porter JG, Wang Y, Schwartz K, et al: Characterization of the atrial natriuretic peptide clearance receptor using a vaccinia virus expression vector. J Biol Chem. 263:18827–18833. 1988.PubMed/NCBI

29 

Maack T, Suzuki M, Almeida FA, et al: Physiological role of silent receptors of atrial natriuretic factor. Science. 238:675–678. 1987. View Article : Google Scholar : PubMed/NCBI

30 

Koller KJ, Lowe DG, Bennett GL, et al: Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). Science (New York, NY). 252:120–123. 1991. View Article : Google Scholar

31 

Suga S, Nakao K, Hosoda K, et al: Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology. 130:229–239. 1992.PubMed/NCBI

32 

Johns DG, Ao Z, Heidrich BJ, et al: Dendroaspis natriuretic peptide binds to the natriuretic peptide clearance receptor. Biochem Biophys Res Commun. 358:145–149. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Park BH, Kim SY, Kim SM, Noh HJ, Cho CG and Kim SZ: Characteristics of dendroaspis natriuretic peptide and its receptor in streptozotocin‑induced diabetic rats. Mol Med Rep 12: 2969-2976, 2015.
APA
Park, B.H., Kim, S.Y., Kim, S.M., Noh, H.J., Cho, C.G., & Kim, S.Z. (2015). Characteristics of dendroaspis natriuretic peptide and its receptor in streptozotocin‑induced diabetic rats. Molecular Medicine Reports, 12, 2969-2976. https://doi.org/10.3892/mmr.2015.3678
MLA
Park, B. H., Kim, S. Y., Kim, S. M., Noh, H. J., Cho, C. G., Kim, S. Z."Characteristics of dendroaspis natriuretic peptide and its receptor in streptozotocin‑induced diabetic rats". Molecular Medicine Reports 12.2 (2015): 2969-2976.
Chicago
Park, B. H., Kim, S. Y., Kim, S. M., Noh, H. J., Cho, C. G., Kim, S. Z."Characteristics of dendroaspis natriuretic peptide and its receptor in streptozotocin‑induced diabetic rats". Molecular Medicine Reports 12, no. 2 (2015): 2969-2976. https://doi.org/10.3892/mmr.2015.3678
Copy and paste a formatted citation
x
Spandidos Publications style
Park BH, Kim SY, Kim SM, Noh HJ, Cho CG and Kim SZ: Characteristics of dendroaspis natriuretic peptide and its receptor in streptozotocin‑induced diabetic rats. Mol Med Rep 12: 2969-2976, 2015.
APA
Park, B.H., Kim, S.Y., Kim, S.M., Noh, H.J., Cho, C.G., & Kim, S.Z. (2015). Characteristics of dendroaspis natriuretic peptide and its receptor in streptozotocin‑induced diabetic rats. Molecular Medicine Reports, 12, 2969-2976. https://doi.org/10.3892/mmr.2015.3678
MLA
Park, B. H., Kim, S. Y., Kim, S. M., Noh, H. J., Cho, C. G., Kim, S. Z."Characteristics of dendroaspis natriuretic peptide and its receptor in streptozotocin‑induced diabetic rats". Molecular Medicine Reports 12.2 (2015): 2969-2976.
Chicago
Park, B. H., Kim, S. Y., Kim, S. M., Noh, H. J., Cho, C. G., Kim, S. Z."Characteristics of dendroaspis natriuretic peptide and its receptor in streptozotocin‑induced diabetic rats". Molecular Medicine Reports 12, no. 2 (2015): 2969-2976. https://doi.org/10.3892/mmr.2015.3678
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