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Article

Detection of adenovirus and respiratory syncytial virus in patients with chronic obstructive pulmonary disease: Exacerbation versus stable condition

  • Authors:
    • Nurdan Kokturk
    • Gulendam Bozdayi
    • Senay Yilmaz
    • Bora Doğan
    • Ozlem Gulbahar
    • Seyyal Rota
    • Turkan Tatlicioglu
  • View Affiliations / Copyright

    Affiliations: Department of Pulmonary Medicine, Gazi University Faculty of Medicine, Ankara 06510, Turkey, Department of Clinical Microbiology, Gazi University Faculty of Medicine, Ankara 06510, Turkey, Department of Clinical Microbiology, Alanya State Hospital, Antalya 07400, Turkey, Department of Biochemistry, Gazi University Faculty of Medicine, Ankara 06510, Turkey
  • Pages: 3039-3046
    |
    Published online on: April 24, 2015
       https://doi.org/10.3892/mmr.2015.3681
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Abstract

Latent infection with adenovirus and respiratory syncytial virus (RSV) is associated with chronic obstructive pulmonary disease (COPD). The role of respiratory viral infections are emerging in COPD exacerbations. The present study aimed to investigate the prevalence of adenovirus and RSV serotypes A and B in individuals with acute exacerbations of COPD (COPD‑AE) and stable COPD. Twenty seven patients with COPD‑AE were evaluated using a prospective longitudinal study design. Induced sputum, sera and nasal smears were sampled from patients experiencing COPD‑AE and those in a stable condition. Adenoplex® multiplex polymerase chain reaction (PCR) kits and Invitek RTP® DNA/RNA Virus Mini kits were used for PCR assays of adenovirus and RSV, respectively. Eighteen patients who experienced a COPD‑AE were also evaluated while in a stable condition. The results showed that three sputum samples were positive for adenovirus in patients experiencing an exacerbation, while one was positive among the patients in a stable condition. RSV serotype A was detected in 17/27 (63%) patients with COPD‑AE and 10/18 (55.6%) patients in a stable condition. RSV serotype B was not detected. Patients with COPD‑AE, who were positive for RSV serotype A exhibited higher serum fibrinogen levels than those who were negative (438.60±126.08 mg/dl compared with 287.60±85.91 mg/dl; P=0.004). Eight/ten patients who were positive for RSV serotype A while in a stable condition, were also positive during COPD‑AE. The results of the present study suggested that RSV infection may be prevalent in patients with COPD‑AE and in those in a stable condition. Therefore, chronic RSV infection may occur in COPD. The detection and prevention of RSV may be useful in the management of COPD.
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1 

Wedzicha JA: Role of viruses in exacerbations of chronic obstructive pulmonary disease. Proc Am Thorac Soc. 1:115–120. 2004. View Article : Google Scholar

2 

Hayashi S and Hogg JC: Adenovirus infections and lung disease. Curr Opin Pharmacol. 7:237–243. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Gold DR, Tager IB, Weiss ST, Tosteson TD and Speizer FE: Acute lower respiratory illness in childhood as a predictor of lung function and chronic respiratory symptoms. Am Rev Respir Dis. 140:877–884. 1989. View Article : Google Scholar : PubMed/NCBI

4 

Borg I, Rohde G, Löseke S, Bittscheidt J, Schultze-Werninghaus G, Stephan V and Bufe A: Evaluation of a quantitative real-time PCR for the detection of respiratory syncytial virus in pulmonary diseases. Eur Respir J. 21:944–951. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Turkish Neonatal Society: The seasonal variations of respiratory syncytial virus infections in Turkey: A 2-year epidemiological study. Turk J Pediatr. 54:216–222. 2012.PubMed/NCBI

6 

Beckham JD, Cadena A, Lin J, Piedra PA, Glezen WP, Greenberg SB and Atmar RL: Respiratory viral infections in patients with chronic, obstructive pulmonary disease. J Infect. 50:322–330. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Seemungal T, Harper-Owen R, Bhowmik A, Moric I, Sanderson G, Message S, Maccallum P, Meade TW, Jeffries DJ, Johnston SL and Wedzicha JA: Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 164:1618–1623. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Hogg JC: Role of latent viral infections in chronic obstructive pulmonary disease and asthma. Am J Respir Crit Care Med. 164:S71–S75. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Hogg JC: Latent adenoviral infection in the pathogenesis of emphysema: The Parker B. Francis Lectureship. Chest. 117(Suppl 1): S282–S285. 2000. View Article : Google Scholar

10 

Schwarze J, O’Donnell DR, Rohwedder A and Openshaw PJ: Latency and persistence of respiratory syncytial virus despite T cell immunity. Am J Respir Crit Care Med. 169:801–805. 2004. View Article : Google Scholar : PubMed/NCBI

11 

NHLBI/WHO Workshop Report Global Initiative for chronic obstructive lung disease: Global Strategy for the Diagnosis, Management, and Prevention Of Chronic Obstructive Pulmonary Disease. US Department of Health and Human Services. Public Health Service, National Institutes of Health, Lung and Blood Institute; (NIH Publication No. 2701). April. 2001

12 

Anthonisen NR, Manfreda J, Warren CP, Hershfield ES, Harding GK and Nelson NA: Antibiotic therapy in exacer-bations of chronic obstructive pulmonary disease. Ann Intern Med. 106:196–204. 1987. View Article : Google Scholar : PubMed/NCBI

13 

Bhowmik A, Seemungal TA, Sapsford RJ and Wedzicha JA: Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations. Thorax. 55:114–120. 2000. View Article : Google Scholar : PubMed/NCBI

14 

[No authors listed]. Lung function testing: Selection of reference values and interpretative strategies. American Thoracic Society. Am Rev Respir Dis. 144:1202–1218. 1991. View Article : Google Scholar : PubMed/NCBI

15 

Pin I, Gibson PG, Kolendowicz R, Girgis-Gabardo A, Denburg JA, Hargreave FE and Dolovich J: Use of induced sputum cell counts to investigate airway inflammation in asthma. Thorax. 47:25–29. 1992. View Article : Google Scholar : PubMed/NCBI

16 

Maniatis T and Fritsch EF: Moleculer Cloning: A Laboratory Manual. 3rd edition. Cold Spring Harbor; New York, NY: 1990

17 

Smith CB, Golden CA, Kanner RE and Renzetti AD Jr: Association of viral and Mycoplasma pneumoniae infections with acute respiratory illness in patients with chronic obstructive pulmonary diseases. Am Rev Respir Dis. 121:225–232. 1980.PubMed/NCBI

18 

Walsh EE, Falsey AR and Hennessey PA: Respiratory syncytial and other virus infections in persons with chronic cardiopulmonary disease. Am J Respir Crit Care Med. 160:791–795. 1999. View Article : Google Scholar : PubMed/NCBI

19 

McManus TE, Marley AM, Baxter N, Christie SN, Elborn JS, Heaney LG, Coyle PV and Kidney JC: Acute and latent adenovirus in COPD. Respir Med. 101:2084–2090. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Ko FW, Ip M, Chan PK, Chan MC, To KW, Ng SS, Chau SS, Tang JW and Hui DS: Viral etiology of acute exacerbations of COPD in Hong Kong. Chest. 132:900–908. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Hutchinson AF, Ghimire AK, Thompson MA, Black JF, Brand CA, Lowe AJ, Smallwood DM, Vlahos R, Bozinovski S, Brown GV, et al: A community-based, time-matched, case-control study of respiratory viruses and exacerbations of COPD. Respir Med. 101:2472–2481. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Rohde G, Wiethege A, Borg I, Kauth M, Bauer TT, Gillissen A, Bufe A and Schultze-Werninghaus G: Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: A case-control study. Thorax. 58:37–42. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Falsey AR, Formica MA, Hennessey PA, Criddle MM, Sullender WM and Walsh EE: Detection of respiratory syncytial virus in adults with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 173:639–643. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Camargo CA Jr, Ginde AA, Clark S, Cartwright CP, Falsey AR and Niewoehner DE: Viral pathogens in acute exacerbations of chronic obstructive pulmonary disease. Intern Emerg Med. 3:355–359. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Matsuse T, Hayashi S, Kuwano K, Keunecke H, Jefferies WA and Hogg JC: Latent adenoviral infection in the pathogenesis of chronic airways obstruction. Am Rev Respir Dis. 146:177–184. 1992. View Article : Google Scholar : PubMed/NCBI

26 

Wilkinson TM, Donaldson GC, Johnston SL, Openshaw PJ and Wedzicha JA: Respiratory syncytial virus, airway inflammation, and FEV1 decline in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 173:871–876. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Wedzicha JA, Seemungal TA, MacCallum PK, Paul EA, Donaldson GC, Bhowmik A, Jeffries DJ and Meade TW: Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels. Thromb Haemost. 84:210–215. 2000.PubMed/NCBI

28 

Sikkel MB, Quint JK, Mallia P, Wedzicha JA and Johnston SL: Respiratory syncytial virus persistence in chronic obstructive pulmonary disease. Pediatr Infect Dis J. 27(Suppl 10): S63–S70. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kokturk N, Bozdayi G, Yilmaz S, Doğan B, Gulbahar O, Rota S and Tatlicioglu T: Detection of adenovirus and respiratory syncytial virus in patients with chronic obstructive pulmonary disease: Exacerbation versus stable condition. Mol Med Rep 12: 3039-3046, 2015.
APA
Kokturk, N., Bozdayi, G., Yilmaz, S., Doğan, B., Gulbahar, O., Rota, S., & Tatlicioglu, T. (2015). Detection of adenovirus and respiratory syncytial virus in patients with chronic obstructive pulmonary disease: Exacerbation versus stable condition. Molecular Medicine Reports, 12, 3039-3046. https://doi.org/10.3892/mmr.2015.3681
MLA
Kokturk, N., Bozdayi, G., Yilmaz, S., Doğan, B., Gulbahar, O., Rota, S., Tatlicioglu, T."Detection of adenovirus and respiratory syncytial virus in patients with chronic obstructive pulmonary disease: Exacerbation versus stable condition". Molecular Medicine Reports 12.2 (2015): 3039-3046.
Chicago
Kokturk, N., Bozdayi, G., Yilmaz, S., Doğan, B., Gulbahar, O., Rota, S., Tatlicioglu, T."Detection of adenovirus and respiratory syncytial virus in patients with chronic obstructive pulmonary disease: Exacerbation versus stable condition". Molecular Medicine Reports 12, no. 2 (2015): 3039-3046. https://doi.org/10.3892/mmr.2015.3681
Copy and paste a formatted citation
x
Spandidos Publications style
Kokturk N, Bozdayi G, Yilmaz S, Doğan B, Gulbahar O, Rota S and Tatlicioglu T: Detection of adenovirus and respiratory syncytial virus in patients with chronic obstructive pulmonary disease: Exacerbation versus stable condition. Mol Med Rep 12: 3039-3046, 2015.
APA
Kokturk, N., Bozdayi, G., Yilmaz, S., Doğan, B., Gulbahar, O., Rota, S., & Tatlicioglu, T. (2015). Detection of adenovirus and respiratory syncytial virus in patients with chronic obstructive pulmonary disease: Exacerbation versus stable condition. Molecular Medicine Reports, 12, 3039-3046. https://doi.org/10.3892/mmr.2015.3681
MLA
Kokturk, N., Bozdayi, G., Yilmaz, S., Doğan, B., Gulbahar, O., Rota, S., Tatlicioglu, T."Detection of adenovirus and respiratory syncytial virus in patients with chronic obstructive pulmonary disease: Exacerbation versus stable condition". Molecular Medicine Reports 12.2 (2015): 3039-3046.
Chicago
Kokturk, N., Bozdayi, G., Yilmaz, S., Doğan, B., Gulbahar, O., Rota, S., Tatlicioglu, T."Detection of adenovirus and respiratory syncytial virus in patients with chronic obstructive pulmonary disease: Exacerbation versus stable condition". Molecular Medicine Reports 12, no. 2 (2015): 3039-3046. https://doi.org/10.3892/mmr.2015.3681
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