Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2015 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2015 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Protective effects of extendin‑4 on hypoxia/reoxygenation‑induced injury in H9c2 cells

Corrigendum in: /10.3892/mmr.2020.11159
  • Authors:
    • Kai Lu
    • Guanglei Chang
    • Lin Ye
    • Peng Zhang
    • Yong Li
    • Dongying Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China, Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
  • Pages: 3007-3016
    |
    Published online on: April 24, 2015
       https://doi.org/10.3892/mmr.2015.3682
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Glucagon-like peptide-1 (GLP-1) analogues are likely to exert cardioprotective effects via balancing the energy metabolism in cardiomyocytes following ischemic or hypoxic insults. The present study aimed to explore the protective effects and mechanism of exendin‑4, a GLP‑1 analogue, on cardiomyocyte glucose uptake using an in vitro model of hypoxia/reoxygenation (H/R) of H9c2 cardiomyocyte cells. Pre‑treatment with exendin‑4 (200 nM) prior to H/R increased the cell viability, decreased cell apoptosis, enhanced cardiomyocyte glucose uptake and increased the production of adenosine triphosphate. Exendin‑4 also decreased the levels of lactate dehydrogenase and creatine kinase‑MB in the culture medium. Furthermore, the activity of carnitine palmitoyltransferase‑1 in the H9c2 cells was decreased, while the activity of phosphofructokinase‑1 was increased following exendin‑4 treatment. Moreover, pre‑treatment with exendin‑4 increased the expression of p38 mitogen‑activated protein kinase (p38MAPK) γ and translocation of glucose transporter‑1 in H9c2 cells subjected to H/R. However, these effects were attenuated by the p38MAPK inhibitors BIRB796 and SB203580. The results suggested that exendin‑4 exerted significant cardioprotective effects against H/R‑induced cell injury and restored the metabolic imbalance of cardiomyocytes by activating the p38MAPK signaling pathway in the H9c2 cell model. Importantly, p38MAPKγ, one subunit of p38MAPK, may have the most important function in this process. The results of the present study may be helpful in the development of novel drugs to treat patients with coronary heart disease.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Hütter JF and Soboll S: Role of fatty acid metabolites in the development of myocardial ischemic damage. Int J Biochem. 24:399–403. 1992. View Article : Google Scholar : PubMed/NCBI

2 

Gambert S, Vergely C, Filomenko R, Moreau D, Bettaieb A, Opie LH and Rochette L: Adverse effects of free fatty acid associated with increased oxidative stress in postischemic isolated rat hearts. Mol Cell Biochem. 283:147–152. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Grynberg A: Effectors of fatty acid oxidation reduction: Promising new anti-ischaemic agents. Curr Pharm Des. 11:489–509. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Avogaro A: Cardioprotective effects of glucagon-like peptide-1: Preclinical and clinical data. G Ital Cardiol (Rome). 12(Suppl 2): 17–24. 2011.In Italian.

5 

Otto-Buczkowska E: Glucagon and glucagon-like peptides the role in control glucose homeostasis. Part I. Pediatr Endocrinol Diabetes Metab. 17:215–221. 2011.In Polish.

6 

Gallwitz B: Anorexigenic effects of GLP-1 and its analogues. Handb Exp Pharmacol. 209:185–207. 2012.PubMed/NCBI

7 

Quintanilla-García C and Zúñiga-Guajardo S: The incretin effect and type 2 diabetes. Rev Med Inst Mex Seguro Soc. 48:509–520. 2010.In Spanish.

8 

Lindamood CA and Taylor JR: Emerging new therapies for the treatment of type 2 diabetes mellitus: Glucagon-like peptide-1 receptor agonists. Clin Ther. Feb 3–2015.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

9 

Harris KB and McCarty DJ: Efficacy and tolerability of glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes mellitus. Ther Adv Endocrinol Metab. 6:3–18. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Bao W, Aravindhan K, Alsaid H, Chendrimada T, Szapacs M, Citerone DR, Harpel MR, Willette RN, Lepore JJ and Jucker BM: Albiglutide, a long lasting glucagon-like peptide-1 analog, protects the rat heart against ischemia/reperfusion injury: Evidence for improving cardiac metabolic efficiency. PLoS One. 6:e235702011. View Article : Google Scholar : PubMed/NCBI

11 

Bose AK, Mocanu MM, Carr RD, Brand CL and Yellon DM: Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. Diabetes. 54:146–151. 2005. View Article : Google Scholar

12 

Bose AK, Mocanu MM, Carr RD and Yellon DM: Glucagon like peptide-1 is protective against myocardial ischemia/reperfusion injury when given either as a preconditioning mimetic or at reperfusion in an isolated rat heart model. Cardiovasc Drugs Ther. 19:9–11. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Read PA, Khan FZ and Dutka DP: Cardioprotection against ischaemia induced by dobutamine stress using glucagon-like peptide-1 in patients with coronary artery disease. Heart. 98:408–413. 2012. View Article : Google Scholar

14 

Read PA, Hoole SP, White PA, Khan FZ, O’Sullivan M, West NE and Dutka DP: A pilot study to assess whether glucagon-like peptide-1 protects the heart from ischemic dysfunction and attenuates stunning after coronary balloon occlusion in humans. Circ Cardiovasc Interv. 4:266–272. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Phong WY, Lin W, Rao SP, Dick T, Alonso S and Pethe K: Characterization of phosphofructokinase activity in Mycobacterium tuberculosis reveals that a functional glycolytic carbon flow is necessary to limit the accumulation of toxic metabolic intermediates under hypoxia. PLoS One. 8:e560372013. View Article : Google Scholar : PubMed/NCBI

16 

Idrovo JP, Yang WL, Nicastro J, Coppa GF and Wang P: Stimulation of carnitine palmitoyltransferase 1 improves renal function and attenuates tissue damage after ischemia/reperfusion. J Surg Res. 177:157–164. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Rajaram N, Frees AE, Fontanella AN, Zhong J, Hansen K, Dewhirst MW and Ramanujam N: Delivery rate affects uptake of a fluorescent glucose analog in murine metastatic breast cancer. PLoS One. 8:e765242013. View Article : Google Scholar : PubMed/NCBI

18 

Lee J and Chang JH: Facile and high-efficient immobilization of histidinetagged multimeric protein G on magnetic nanoparticles. Nanoscale Res Lett. 9:6642014. View Article : Google Scholar

19 

Ji L, Zhang X, Liu W, et al: AMPK-regulated and Akt-dependent enhancement of glucose uptake is essential in ischemic preconditioning-alleviated reperfusion injury. PLoS One. 8:e699102013. View Article : Google Scholar : PubMed/NCBI

20 

Moberly SP, Berwick ZC, Kohr M, Svendsen M, Mather KJ and Tune JD: Intracoronary glucagon-like peptide 1 preferentially augments glucose uptake in ischemic myocardium independent of changes in coronary flow. Exp Biol Med (Maywood). 237:334–342. 2012. View Article : Google Scholar

21 

Gejl M, Søndergaard HM, Stecher C, Bibby BM, Møller N, Bøtker HE, Hansen SB, Gjedde A, Rungby J and Brock B: Exenatide alters myocardial glucose transport and uptake depending on insulin resistance and increases myocardial blood flow in patients with type 2 diabetes. J Clin Endocrinol Metab. 97:E1165–E1169. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Tani M and Neely JR: Role of intracellular Na+ in Ca2+ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Possible involvement of H+-Na+ and Na+-Ca2+ exchange. Circ Res. 65:1045–1056. 1989. View Article : Google Scholar : PubMed/NCBI

23 

Ferrari R, Pepi P, Ferrari F, et al: Metabolic derangement in ischemic heart disease and its therapeutic control. Am J Cardiol. 82:2K–13K. 1998. View Article : Google Scholar : PubMed/NCBI

24 

Mor I, Cheung EC and Vousden KH: Control of glycolysis through regulation of PFK1: Old friends and recent additions. Cold Spring Harb Symp Quant Biol. 76:211–216. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Aoi W, Naito Y and Yoshikawa T: Potential role of oxidative protein modification in energy metabolism in exercise. Subcell Biochem. 77:175–187. 2014.PubMed/NCBI

26 

Nguyen TD, Shingu Y, Amorim PA, Schwarzer M and Doenst T: Glucagon-like peptide-1 reduces contractile function and fails to boost glucose utilization in normal hearts in the presence of fatty acids. Int J Cardiol. 168:4085–4092. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Zhao T, Parikh P, Bhashyam S, Bolukoglu H, Poornima I, Shen YT and Shannon RP: Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts. J Pharmacol Exp Ther. 317:1106–1113. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Moberly SP, Mather KJ, Berwick ZC, Owen MK, Goodwill AG, Casalini ED, Hutchins GD, Green MA, Ng Y, Considine RV, et al: Impaired cardiometabolic responses to glucagon-like peptide 1 in obesity and type 2 diabetes mellitus. Basic Res Cardiol. 108:3652013. View Article : Google Scholar : PubMed/NCBI

29 

Cuenda A and Rousseau S: p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta. 1773:1358–1375. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Erdogdu O, Eriksson L, Xu H, Sjöholm A, Zhang Q and Nyström T: Exendin-4 protects endothelial cells from lipoapoptosis by PKA, PI3K, eNOS, p38 MAPK, and JNK pathways. J Mol Endocrinol. 50:229–241. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Xu H, Li HL, Niu ZY, Li GZ, Cao J and Jiang YD: Involvement of p38 MAPK pathway in GLP-1-induced inhibition of apoptosis in human umbilical vein endothelial cells. Sheng Li Xue Bao. 64:444–448. 2012.In Chinese. PubMed/NCBI

32 

Kawasaki Y, Harashima S, Sasaki M, Mukai E, Nakamura Y, Harada N, Toyoda K, Hamasaki A, Yamane S, Yamada C, et al: Exendin-4 protects pancreatic beta cells from the cytotoxic effect of rapamycin by inhibiting JNK and p38 phosphorylation. Horm Metab Res. 42:311–317. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Ho RC, Alcazar O, Fujii N, Hirshman MF and Goodyear LJ: p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 286:R342–R349. 2004. View Article : Google Scholar

34 

Bhashyam S, Fields AV, Patterson B, Testani JM, Chen L, Shen YT and Shannon RP: Glucagon-like peptide-1 increases myocardial glucose uptake via p38alpha MAP kinasemediated, nitric oxide-dependent mechanisms in conscious dogs with dilated cardiomyopathy. Circ Heart Fail. 3:512–521. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Kuma Y, Sabio G, Bain J, Shpiro N, Márquez R and Cuenda A: BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo. J Biol Chem. 280:19472–19479. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Caverzasio J and Manen D: Essential role of Wnt3a-mediated activation of mitogen-activated protein kinase p38 for the stimulation of alkaline phosphatase activity and matrix mineralization in C3H10T1/2 mesenchymal cells. Endocrinology. 148:5323–5330. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Dingar D, Merlen C, Grandy S, Gillis MA, Villeneuve LR, Mamarbachi AM, Fiset C and Allen BG: Effect of pressure overload-induced hypertrophy on the expression and localization of p38 MAP kinase isoforms in the mouse heart. Cell Signal. 22:1634–1644. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Huisamen B, Genade S and Lochner A: Signalling pathways activated by glucagon-like peptide-1 (7–36) amide in the rat heart and their role in protection against ischaemia. Cardiovasc J Afr. 19:77–83. 2008.PubMed/NCBI

39 

Vyas AK, Yang KC, Woo D, Tzekov A, Kovacs A, Jay PY and Hruz PW: Exenatide improves glucose homeostasis and prolongs survival in a murine model of dilated cardiomyopathy. PLoS One. 6:e171782011. View Article : Google Scholar : PubMed/NCBI

40 

Liu Q, Anderson C, Broyde A, Polizzi C, Fernandez R, Baron A and Parkes DG: Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure. Cardiovasc Diabetol. 9:762010. View Article : Google Scholar : PubMed/NCBI

41 

Arnés L, Moreno P, Nuche-Berenguer B, Valverde I and Villanueva-Peñacarrillo ML: Effect of exendin-4 treatment upon glucose uptake parameters in rat liver and muscle, in normal and type 2 diabetic state. Regul Pept. 153:88–92. 2009. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lu K, Chang G, Ye L, Zhang P, Li Y and Zhang D: Protective effects of extendin‑4 on hypoxia/reoxygenation‑induced injury in H9c2 cells Corrigendum in /10.3892/mmr.2020.11159. Mol Med Rep 12: 3007-3016, 2015.
APA
Lu, K., Chang, G., Ye, L., Zhang, P., Li, Y., & Zhang, D. (2015). Protective effects of extendin‑4 on hypoxia/reoxygenation‑induced injury in H9c2 cells Corrigendum in /10.3892/mmr.2020.11159. Molecular Medicine Reports, 12, 3007-3016. https://doi.org/10.3892/mmr.2015.3682
MLA
Lu, K., Chang, G., Ye, L., Zhang, P., Li, Y., Zhang, D."Protective effects of extendin‑4 on hypoxia/reoxygenation‑induced injury in H9c2 cells Corrigendum in /10.3892/mmr.2020.11159". Molecular Medicine Reports 12.2 (2015): 3007-3016.
Chicago
Lu, K., Chang, G., Ye, L., Zhang, P., Li, Y., Zhang, D."Protective effects of extendin‑4 on hypoxia/reoxygenation‑induced injury in H9c2 cells Corrigendum in /10.3892/mmr.2020.11159". Molecular Medicine Reports 12, no. 2 (2015): 3007-3016. https://doi.org/10.3892/mmr.2015.3682
Copy and paste a formatted citation
x
Spandidos Publications style
Lu K, Chang G, Ye L, Zhang P, Li Y and Zhang D: Protective effects of extendin‑4 on hypoxia/reoxygenation‑induced injury in H9c2 cells Corrigendum in /10.3892/mmr.2020.11159. Mol Med Rep 12: 3007-3016, 2015.
APA
Lu, K., Chang, G., Ye, L., Zhang, P., Li, Y., & Zhang, D. (2015). Protective effects of extendin‑4 on hypoxia/reoxygenation‑induced injury in H9c2 cells Corrigendum in /10.3892/mmr.2020.11159. Molecular Medicine Reports, 12, 3007-3016. https://doi.org/10.3892/mmr.2015.3682
MLA
Lu, K., Chang, G., Ye, L., Zhang, P., Li, Y., Zhang, D."Protective effects of extendin‑4 on hypoxia/reoxygenation‑induced injury in H9c2 cells Corrigendum in /10.3892/mmr.2020.11159". Molecular Medicine Reports 12.2 (2015): 3007-3016.
Chicago
Lu, K., Chang, G., Ye, L., Zhang, P., Li, Y., Zhang, D."Protective effects of extendin‑4 on hypoxia/reoxygenation‑induced injury in H9c2 cells Corrigendum in /10.3892/mmr.2020.11159". Molecular Medicine Reports 12, no. 2 (2015): 3007-3016. https://doi.org/10.3892/mmr.2015.3682
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team