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Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor

  • Authors:
    • Rui Huang
    • Guiyu Wang
    • Yanni Song
    • Qingchao Tang
    • Qi You
    • Zheng Liu
    • Yinggang Chen
    • Qian Zhang
    • Jiaying Li
    • Shan Muhammand
    • Xishan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China, Department of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 2417-2424
    |
    Published online on: April 28, 2015
       https://doi.org/10.3892/mmr.2015.3694
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Abstract

Colorectal cancer stem cells (Co-CSCs) are a small subpopulation of tumor cells which have been proposed to be tumor‑initiating cells in colorectal cancer (CRC) and to be implicated in resistance to standard chemotherapy. Chemoresistance is a common problem in the clinic. However, the interrelation between Co‑CSCs and chemoresistant cells has yet to be elucidated. The present study investigated the Co‑CSC phenotype in colonospheres and chemoresistant CRC cell lines and aimed to identify targets for therapy. Colonospheres and chemoresistant CRC cells were found to be enriched with the CSC markers CD133 and CD44, and exhibited similar phenotypes. Furthermore, it was found that Notch signaling may simultaneously regulate Co‑CSCs and chemoresistant cells and may represent a novel strategy for targeting this pathway in CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Huang R, Wang G, Song Y, Tang Q, You Q, Liu Z, Chen Y, Zhang Q, Li J, Muhammand S, Muhammand S, et al: Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor. Mol Med Rep 12: 2417-2424, 2015.
APA
Huang, R., Wang, G., Song, Y., Tang, Q., You, Q., Liu, Z. ... Wang, X. (2015). Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor. Molecular Medicine Reports, 12, 2417-2424. https://doi.org/10.3892/mmr.2015.3694
MLA
Huang, R., Wang, G., Song, Y., Tang, Q., You, Q., Liu, Z., Chen, Y., Zhang, Q., Li, J., Muhammand, S., Wang, X."Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor". Molecular Medicine Reports 12.2 (2015): 2417-2424.
Chicago
Huang, R., Wang, G., Song, Y., Tang, Q., You, Q., Liu, Z., Chen, Y., Zhang, Q., Li, J., Muhammand, S., Wang, X."Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor". Molecular Medicine Reports 12, no. 2 (2015): 2417-2424. https://doi.org/10.3892/mmr.2015.3694
Copy and paste a formatted citation
x
Spandidos Publications style
Huang R, Wang G, Song Y, Tang Q, You Q, Liu Z, Chen Y, Zhang Q, Li J, Muhammand S, Muhammand S, et al: Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor. Mol Med Rep 12: 2417-2424, 2015.
APA
Huang, R., Wang, G., Song, Y., Tang, Q., You, Q., Liu, Z. ... Wang, X. (2015). Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor. Molecular Medicine Reports, 12, 2417-2424. https://doi.org/10.3892/mmr.2015.3694
MLA
Huang, R., Wang, G., Song, Y., Tang, Q., You, Q., Liu, Z., Chen, Y., Zhang, Q., Li, J., Muhammand, S., Wang, X."Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor". Molecular Medicine Reports 12.2 (2015): 2417-2424.
Chicago
Huang, R., Wang, G., Song, Y., Tang, Q., You, Q., Liu, Z., Chen, Y., Zhang, Q., Li, J., Muhammand, S., Wang, X."Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor". Molecular Medicine Reports 12, no. 2 (2015): 2417-2424. https://doi.org/10.3892/mmr.2015.3694
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