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Article

Expression profile of plasma microRNAs in premature infants with respiratory distress syndrome

  • Authors:
    • Qing Kan
    • Sufang Ding
    • Yang Yang
    • Xiaoyu Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Neonatology, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China, Department of Neonatology, Huaian Maternity and Child Health Care Hospital, Huaian, Jiangsu 223002, P.R. China
  • Pages: 2858-2864
    |
    Published online on: April 29, 2015
       https://doi.org/10.3892/mmr.2015.3699
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Abstract

As well-known regulators of gene expression, microRNAs (miRNAs) are important not only in cell proliferation and differentiation, but also in tumorigenesis and organ development. It has been estimated that miRNAs may be responsible for regulating the expression of almost one third of the human genome. Simultaneously, with advances in neonatal care in the clinic, an increased number of premature infants are being saved and, thus, respiratory distress syndrome (RDS) has become more common. However, previous non‑miRNA studies have suggested their connection with RDS. In the present study, a miRNA microarray, including >1,891 capture probes was used to compared the expression profiles of plasma miRNAs between RDS and control groups. miRNAs, which were observed to have consistent fold‑changes (fold‑change ≥1.3) between the two groups were selected and validated using reverse transcription‑quantitative polymerase chain reaction. As a result, 171 differentially expressed miRNAs were identified, including two upregulated and seven downregulated miRNAs. Of these miRNAs, four were selected as having higher fold‑changes between the two groups. This is the first time, to the best ouf our knowledge, that these nine miRNAs have been reported in RDS. It was hypothesized that these novel miRNAs may be important in RDS, and may provide meaningful biomarkers for the diagnosis of RDS.
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Copy and paste a formatted citation
Spandidos Publications style
Kan Q, Ding S, Yang Y and Zhou X: Expression profile of plasma microRNAs in premature infants with respiratory distress syndrome. Mol Med Rep 12: 2858-2864, 2015.
APA
Kan, Q., Ding, S., Yang, Y., & Zhou, X. (2015). Expression profile of plasma microRNAs in premature infants with respiratory distress syndrome. Molecular Medicine Reports, 12, 2858-2864. https://doi.org/10.3892/mmr.2015.3699
MLA
Kan, Q., Ding, S., Yang, Y., Zhou, X."Expression profile of plasma microRNAs in premature infants with respiratory distress syndrome". Molecular Medicine Reports 12.2 (2015): 2858-2864.
Chicago
Kan, Q., Ding, S., Yang, Y., Zhou, X."Expression profile of plasma microRNAs in premature infants with respiratory distress syndrome". Molecular Medicine Reports 12, no. 2 (2015): 2858-2864. https://doi.org/10.3892/mmr.2015.3699
Copy and paste a formatted citation
x
Spandidos Publications style
Kan Q, Ding S, Yang Y and Zhou X: Expression profile of plasma microRNAs in premature infants with respiratory distress syndrome. Mol Med Rep 12: 2858-2864, 2015.
APA
Kan, Q., Ding, S., Yang, Y., & Zhou, X. (2015). Expression profile of plasma microRNAs in premature infants with respiratory distress syndrome. Molecular Medicine Reports, 12, 2858-2864. https://doi.org/10.3892/mmr.2015.3699
MLA
Kan, Q., Ding, S., Yang, Y., Zhou, X."Expression profile of plasma microRNAs in premature infants with respiratory distress syndrome". Molecular Medicine Reports 12.2 (2015): 2858-2864.
Chicago
Kan, Q., Ding, S., Yang, Y., Zhou, X."Expression profile of plasma microRNAs in premature infants with respiratory distress syndrome". Molecular Medicine Reports 12, no. 2 (2015): 2858-2864. https://doi.org/10.3892/mmr.2015.3699
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