Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2015 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2015 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function

  • Authors:
    • Shao‑Lin Zeng
    • Li‑Hui Wang
    • Ping Li
    • Wei Wang
    • Jiong Yang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, P.R. China
    Copyright: © Zeng et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 2511-2520
    |
    Published online on: April 30, 2015
       https://doi.org/10.3892/mmr.2015.3706
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Mesenchymal stem cells (MSCs) have been investigated in the treatment of numerous autoimmune diseases. However, the immune properties of MSCs on the development of asthma have remained to be fully elucidated. Airway dendritic cells (DCs) have an important role in the pathogenesis of allergic asthma, and disrupting their function may be a novel therapeutic approach. The present study used a mouse model of asthma to demonstrate that transplantation of MSCs suppressed features of asthma by targeting the function of lung myeloid DCs. MSCs suppressed the maturation and migration of lung DCs to the mediastinal lymph nodes, and thereby reducing the allergen‑specific T helper type 2 (Th2) response in the nodes. In addition, MSC‑treated DCs were less potent in activating naive and effector Th2 cells and the capacity of producing chemokine (C‑C motif) ligand 17 (CCL17) and CCL22, which are chemokines attracting Th2 cells, to the airways was reduced. These results supported that MSCs may be used as a potential treatment for asthma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Rasmusson I: Immune modulation by mesenchymal stem cells. Exp Cell Res. 312:2169–2179. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Uccelli A, Moretta L and Pistoia V: Mesenchymal stem cells in health and disease. Nat Rev Immunol. 8:726–736. 2008. View Article : Google Scholar

3 

Prockop DJ, Kota DJ, Bazhanov N and Reger RL: Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs). J Cell Mol Med. 14:2190–2199. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Liang J, Gu F, Wang H, et al: Mesenchymal stem cell transplantation for diffuse alveolar hemorrhage in SLE. Nat Rev Rheumatol. 6:486–489. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Gonzalez-Rey E, Gonzalez MA, Varela N, et al: Human adipose-derived mesenchymal stem cells reduce inflammatory and T cell responses and induce regulatory T cells in vitro in rheumatoid arthritis. Ann Rheum Dis. 69:241–248. 2010. View Article : Google Scholar

6 

Parekkadan B, Tilles AW and Yarmush ML: Bone marrow-derived mesenchymal stem cells ameliorate autoimmune enteropathy independently of regulatory T cells. Stem Cells. 26:1913–1919. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Ringdén O, Uzunel M, Rasmusson I, et al: Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation. 81:1390–1397. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Firinci F, Karaman M, Baran Y, et al: Mesenchymal stem cells ameliorate the histopathological changes in a murine model of chronic asthma. Int Immunopharmacol. 11:1120–1126. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Lee SH, Jang AS, Kwon JH, Park SK, Won JH and Park CS: Mesenchymal stem cell transfer suppresses airway remodeling in a toluene diisocyanate-induced murine asthma model. Allergy Asthma Immunol Res. 3:205–211. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Ge X, Bai C, Yang J, Lou G, Li Q and Chen R: Effect of mesenchymal stem cells on inhibiting airway remodeling and airway inflammation in chronic asthma. J Cell Biochem. 114:1595–1605. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Wills-Karp M: Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol. 17:255–281. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Banchereau J and Steinman RM: Dendritic cells and the control of immunity. Nature. 392:245–252. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Stumbles PA, Thomas JA, Pimm CL, et al: Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity. J Exp Med. 188:2019–2031. 1998. View Article : Google Scholar : PubMed/NCBI

14 

McWilliam AS, Nelson DJ and Holt PG: The biology of airway dendritic cells. Immunol Cell Biol. 73:405–413. 1995. View Article : Google Scholar : PubMed/NCBI

15 

Hammad H and Lambrecht BN: Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma. Nat Rev Immunol. 8:193–204. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Jahnsen FL, Moloney ED, Hogan T, Upham JW, Burke CM and Holt PG: Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge. Thorax. 56:823–826. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Moller GM, Overbeek SE, Van Helden-Meeuwsen CG, et al: Increased numbers of dendritic cells in the bronchial mucosa of atopic asthmatic patients: downregulation by inhaled corticosteroids. Clin Exp Allergy. 26:517–524. 1996. View Article : Google Scholar

18 

van Rijt LS, Prins JB, Leenen PJ, et al: Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31(hi)Ly-6C(neg) bone marrow precursors in a mouse model of asthma. Blood. 100:3663–3671. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Zhang W, Ge W, Li C, et al: Effects of mesenchymal stem cells on differentiation, maturation and function of human monocyte-derived dendritic cells. Stem Cells Dev. 13:263–271. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Beyth S, Borovsky Z, Mevorach D, et al: Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood. 105:2214–2219. 2005. View Article : Google Scholar

21 

English K, Barry FP and Mahon BP: Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation. Immunol Lett. 115:50–58. 2008. View Article : Google Scholar

22 

National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals: Guide for the Care and Use of Laboratory Animals. 8th edition. Washington (DC): National Academies Press (US); 2011

23 

Peister A, Mellad JA, Larson BL, Hall BM, Gibson LF and Prockop DJ: Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation and differentiation potential. Blood. 103:1662–1668. 2004. View Article : Google Scholar

24 

English K, Barry FP, Field-Corbett CP and Mahon BP: IFN-gamma and TNF-alpha differentially regulate immunomodulation by murine mesenchymal stem cells. Immunol Lett. 110:91–100. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Vermaelen KY, Carro-Muino I, Lambrecht BN and Pauwels RA: Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes. J Exp Med. 193:51–60. 2001. View Article : Google Scholar : PubMed/NCBI

26 

de Heer HJ, Hammad H, Soullié T, et al: Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med. 200:89–98. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Lambrecht BN, De Veerman M, Coyle AJ, Gutierrez-Ramos JC, Thielemans K and Pauwels RA: Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J Clin Invest. 106:551–559. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Hamelmann E, Schwarze J, Takeda K, et al: Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med. 156:766–775. 1997. View Article : Google Scholar : PubMed/NCBI

29 

van Rijt LS, Jung S, Kleinjan A, et al: In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J Exp Med. 201:981–991. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Zumbuehl A, Stano P, Heer D, Walde P and Carreira EM: Amphotericin B as a potential probe of the physical state of vesicle membranes. Org Lett. 6:3683–3686. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Rafei M, Campeau PM, Aguilar-Mahecha A, et al: Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner. J Immunol. 182:5994–6002. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Lee RH, Seo MJ, Reger RL, et al: Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proc Natl Acad Sci USA. 103:17438–17443. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Augello A, Tasso R, Negrini SM, Cancedda R and Pennesi G: Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis. Arthritis Rheum. 56:1175–1186. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Sun L, Akiyama K, Zhang H, et al: Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans. Stem Cells. 27:1421–1432. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Kapoor S, Patel SA, Kartan S, Axelrod D, Capitle E and Rameshwar P: Tolerance-like mediated suppression by mesenchymal stem cells in patients with dust mite allergy-induced asthma. J Allergy Clin Immunol. 129:1094–1101. 2012. View Article : Google Scholar

36 

Firinci F, Karaman M, Baran Y, et al: Mesenchymal stem cells ameliorate the histopathological changes in a murine model of chronic asthma. Int Immunopharmacol. 11:1120–1126. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Atsma DE, Fibbe WE and Rabelink TJ: Opportunities and challenges for mesenchymal stem cell-mediated heart repair. Curr Opin Lipidol. 18:645–649. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Le Blanc K and Ringdén O: Immunomodulation by mesenchymal stem cells and clinical experience. J Intern Med. 262:509–525. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Kohl J, Baelder R, Lewkowich IP, et al: A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. J Clin Invest. 116:783–796. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Huh JC, Strickland DH, Jahnsen FL, et al: Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma. J Exp Med. 198:19–30. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Vermaelen KY, Cataldo D, Tournoy K, et al: Matrix metallopro-teinase-9-mediated dendritic cell recruitment into the airways is a critical step in a mouse model of asthma. J Immunol. 171:1016–1022. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Zhou B, Comeau MR, De Smedt T, et al: Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol. 6:1047–1053. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Lambrecht BN and Hammad H: Taking our breath away: dendritic cells in the pathogenesis of asthma. Nat Rev Immunol. 3:994–1003. 2003. View Article : Google Scholar : PubMed/NCBI

44 

Vermaelen K and Pauwels R: Accelerated airway dendritic cell maturation, trafficking and elimination in a mouse model of asthma. Am J Respir Cell Mol Biol. 29:405–409. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Harris NL, Watt V, Ronchese F and Le Gros G: Differential T cell function and fate in lymph node and nonlymphoid tissues. J Exp Med. 195:317–326. 2002. View Article : Google Scholar : PubMed/NCBI

46 

Lewkowich IP, Rempel JD and HayGlass KT: Prevention of allergen-specific, Th2-biased immune responses in vivo: role of increased IL-12 and IL-18 responsiveness. J Immunol. 175:4956–4962. 2005. View Article : Google Scholar : PubMed/NCBI

47 

van Rijt LS, Vos N, Willart M, et al: Essential role of dendritic cell CD80/CD86 costimulation in the induction, but not reactivation, of TH2 effector responses in a mouse model of asthma. J Allergy Clin Immunol. 114:166–173. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Wikstrom ME and Stumbles PA: Mouse respiratory tract dendritic cell subsets and the immunological fate of inhaled antigens. Immunol Cell Biol. 85:182–188. 2007.PubMed/NCBI

49 

GeurtsvanKessel CH and Lambrecht BN: Division of labor between dendritic cell subsets of the lung. Mucosal Immunol. 1:442–450. 2008. View Article : Google Scholar : PubMed/NCBI

50 

Sung SS, Fu SM, Rose CE Jr, Gaskin F, Ju ST and Beaty SR: A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins. J Immunol. 176:2161–2172. 2006. View Article : Google Scholar : PubMed/NCBI

51 

Beaty SR, Rose CE Jr and Sung SS: Diverse and potent chemokine production by lung CD11bhigh dendritic cells in homeostasis and in allergic lung inflammation. J Immunol. 178:1882–1895. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Sallusto F, Lenig D, Mackay CR and Lanzavecchia A: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med. 187:875–883. 1998. View Article : Google Scholar : PubMed/NCBI

53 

Panina-Bordignon P, Papi A, Mariani M, et al: The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J Clin Invest. 107:1357–1364. 2001. View Article : Google Scholar : PubMed/NCBI

54 

Pilette C, Francis JN, Till SJ and Durham SR: CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge. Eur Respir J. 23:876–884. 2004. View Article : Google Scholar : PubMed/NCBI

55 

Perros F, Hoogsteden HC, Coyle AJ, Lambrecht BN and Hammad H: Blockade of CCR4 in a humanized model of asthma reveals a critical role for DC-derived CCL17 and CCL22 in attracting Th2 cells and inducing airway inflammation. Allergy. 64:995–1002. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zeng SL, Wang LH, Li P, Wang W and Yang J: Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function. Mol Med Rep 12: 2511-2520, 2015.
APA
Zeng, S., Wang, L., Li, P., Wang, W., & Yang, J. (2015). Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function. Molecular Medicine Reports, 12, 2511-2520. https://doi.org/10.3892/mmr.2015.3706
MLA
Zeng, S., Wang, L., Li, P., Wang, W., Yang, J."Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function". Molecular Medicine Reports 12.2 (2015): 2511-2520.
Chicago
Zeng, S., Wang, L., Li, P., Wang, W., Yang, J."Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function". Molecular Medicine Reports 12, no. 2 (2015): 2511-2520. https://doi.org/10.3892/mmr.2015.3706
Copy and paste a formatted citation
x
Spandidos Publications style
Zeng SL, Wang LH, Li P, Wang W and Yang J: Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function. Mol Med Rep 12: 2511-2520, 2015.
APA
Zeng, S., Wang, L., Li, P., Wang, W., & Yang, J. (2015). Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function. Molecular Medicine Reports, 12, 2511-2520. https://doi.org/10.3892/mmr.2015.3706
MLA
Zeng, S., Wang, L., Li, P., Wang, W., Yang, J."Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function". Molecular Medicine Reports 12.2 (2015): 2511-2520.
Chicago
Zeng, S., Wang, L., Li, P., Wang, W., Yang, J."Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function". Molecular Medicine Reports 12, no. 2 (2015): 2511-2520. https://doi.org/10.3892/mmr.2015.3706
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team