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A novel intracerebral hemorrhage-induced rat model of neurogenic voiding dysfunction: Analysis of lower urinary tract function

  • Authors:
    • Young‑Sam Cho
    • Il-Gyu Ko
    • Chang-Ju Kim
    • Khae‑Hawn Kim
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 110‑746, Republic of Korea, Department of Physiology, Kyung Hee University College of Medicine, Seoul 130‑701, Republic of Korea, Department of Urology, Gachon University School of Medicine, Gil Medical Center, Incheon 405‑760, Republic of Korea
    Copyright: © Cho et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 2563-2569
    |
    Published online on: May 4, 2015
       https://doi.org/10.3892/mmr.2015.3720
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Abstract

Neurogenic lower urinary tract dysfunction (NLUTD) is a major problem in patients with various neurological disorders, and may result in debilitating symptoms and serious complications, including chronic renal failure and recurrent urinary tract infections. Clinically, stroke is associated with voiding dysfunction. However, lower urinary tract function evaluation in an intracerebral hemorrhage (ICH) model has not, to the best of our knowledge, been reported. Therefore, in the present study, lower urinary tract function in ICH‑induced rats was investigated and the results were compared with those obtained in normal rats. The effects of ICH on peripheral bladder function and central micturition centers [medial preoptic area, ventrolateral gray, pontaine micturition center and spinal cord (lumbar 4 (L4)‑L5)] were also examined. Adult female Sprague‑Dawley rats were divided into two groups: Control ICH‑induced. Induction of ICH in the hippocampal CA1 region was performed using a stereotaxic frame and type IV collagenase. The effects of ICH on the central micturition centers were investigated by simultaneously determining the extent of neuronal activation (c‑Fos) and nerve growth factor (NGF) expression, and assessing voiding function (urodynamically using cystometry). The results revealed that induction of ICH significantly enhanced bladder contraction pressure and time, while simultaneously reducing voiding pressure and time. Furthermore, the c‑Fos and NGF expression levels in the neuronal voiding centers were significantly increased in the rats with induced ICH as compared with the control rats. Therefore, this ICH‑induced NLUTD rat model may be a more appropriate method to analyze NLUTD in stroke patients than a cerebral infarction model, as the former more accurately reflects the nature of the hemorrhage in the two types of stroke.
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Copy and paste a formatted citation
Spandidos Publications style
Cho YS, Ko I, Kim C and Kim KH: A novel intracerebral hemorrhage-induced rat model of neurogenic voiding dysfunction: Analysis of lower urinary tract function. Mol Med Rep 12: 2563-2569, 2015.
APA
Cho, Y., Ko, I., Kim, C., & Kim, K. (2015). A novel intracerebral hemorrhage-induced rat model of neurogenic voiding dysfunction: Analysis of lower urinary tract function. Molecular Medicine Reports, 12, 2563-2569. https://doi.org/10.3892/mmr.2015.3720
MLA
Cho, Y., Ko, I., Kim, C., Kim, K."A novel intracerebral hemorrhage-induced rat model of neurogenic voiding dysfunction: Analysis of lower urinary tract function". Molecular Medicine Reports 12.2 (2015): 2563-2569.
Chicago
Cho, Y., Ko, I., Kim, C., Kim, K."A novel intracerebral hemorrhage-induced rat model of neurogenic voiding dysfunction: Analysis of lower urinary tract function". Molecular Medicine Reports 12, no. 2 (2015): 2563-2569. https://doi.org/10.3892/mmr.2015.3720
Copy and paste a formatted citation
x
Spandidos Publications style
Cho YS, Ko I, Kim C and Kim KH: A novel intracerebral hemorrhage-induced rat model of neurogenic voiding dysfunction: Analysis of lower urinary tract function. Mol Med Rep 12: 2563-2569, 2015.
APA
Cho, Y., Ko, I., Kim, C., & Kim, K. (2015). A novel intracerebral hemorrhage-induced rat model of neurogenic voiding dysfunction: Analysis of lower urinary tract function. Molecular Medicine Reports, 12, 2563-2569. https://doi.org/10.3892/mmr.2015.3720
MLA
Cho, Y., Ko, I., Kim, C., Kim, K."A novel intracerebral hemorrhage-induced rat model of neurogenic voiding dysfunction: Analysis of lower urinary tract function". Molecular Medicine Reports 12.2 (2015): 2563-2569.
Chicago
Cho, Y., Ko, I., Kim, C., Kim, K."A novel intracerebral hemorrhage-induced rat model of neurogenic voiding dysfunction: Analysis of lower urinary tract function". Molecular Medicine Reports 12, no. 2 (2015): 2563-2569. https://doi.org/10.3892/mmr.2015.3720
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