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Article Open Access

Anti-oxidant effect of heme oxygenase-1 on cigarette smoke-induced vascular injury

  • Authors:
    • Genhuan Yang
    • Yanchuan Li
    • Wei Wu
    • Bao Liu
    • Leng Ni
    • Zhanqi Wang
    • Shiying Miao
    • Linfang Wang
    • Changwei Liu
  • View Affiliations / Copyright

    Affiliations: Department of Vascular Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, P.R. China, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100005, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 2481-2486
    |
    Published online on: May 4, 2015
       https://doi.org/10.3892/mmr.2015.3722
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Abstract

Cigarette smoking, a major independent risk factor of atherosclerosis, can cause oxidative and inflammatory damage of vascular tissue. Heme oxygenase-1 (HO-1) is an endogenous cytoprotective enzyme with an anti-oxidant role in cells. The aim of the present study was to investigate whether HO-1 was able to protect vascular and endothelial cells from the oxidative damage induced by cigarette smoking. It was observed that cigarette smoking was able to induce the generation of the reactive oxygen species (ROS) in carotid arteries of rats. Hemin, a widely used HO-1 inducer, was able to reduce the generation of ROS. In addition, when human umbilical vein endothelial cells (HUVECs) were cultured in the serum of smoking rats, this was able to increase ROS, and the protective effect of hemin was also observed in this system. In conclusion, the present study demonstrated that cigarette smoking causes oxidative damage of vascular cells and HUVECs by inducing the generation of ROS, while HO-1 has an anti-oxidant effect in this course. This also implied that hemin, an inducer of HO-1, may have potential therapeutic applicability in the prevention of vascular diseases caused by cigarette smoking.
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Copy and paste a formatted citation
Spandidos Publications style
Yang G, Li Y, Wu W, Liu B, Ni L, Wang Z, Miao S, Wang L and Liu C: Anti-oxidant effect of heme oxygenase-1 on cigarette smoke-induced vascular injury. Mol Med Rep 12: 2481-2486, 2015.
APA
Yang, G., Li, Y., Wu, W., Liu, B., Ni, L., Wang, Z. ... Liu, C. (2015). Anti-oxidant effect of heme oxygenase-1 on cigarette smoke-induced vascular injury. Molecular Medicine Reports, 12, 2481-2486. https://doi.org/10.3892/mmr.2015.3722
MLA
Yang, G., Li, Y., Wu, W., Liu, B., Ni, L., Wang, Z., Miao, S., Wang, L., Liu, C."Anti-oxidant effect of heme oxygenase-1 on cigarette smoke-induced vascular injury". Molecular Medicine Reports 12.2 (2015): 2481-2486.
Chicago
Yang, G., Li, Y., Wu, W., Liu, B., Ni, L., Wang, Z., Miao, S., Wang, L., Liu, C."Anti-oxidant effect of heme oxygenase-1 on cigarette smoke-induced vascular injury". Molecular Medicine Reports 12, no. 2 (2015): 2481-2486. https://doi.org/10.3892/mmr.2015.3722
Copy and paste a formatted citation
x
Spandidos Publications style
Yang G, Li Y, Wu W, Liu B, Ni L, Wang Z, Miao S, Wang L and Liu C: Anti-oxidant effect of heme oxygenase-1 on cigarette smoke-induced vascular injury. Mol Med Rep 12: 2481-2486, 2015.
APA
Yang, G., Li, Y., Wu, W., Liu, B., Ni, L., Wang, Z. ... Liu, C. (2015). Anti-oxidant effect of heme oxygenase-1 on cigarette smoke-induced vascular injury. Molecular Medicine Reports, 12, 2481-2486. https://doi.org/10.3892/mmr.2015.3722
MLA
Yang, G., Li, Y., Wu, W., Liu, B., Ni, L., Wang, Z., Miao, S., Wang, L., Liu, C."Anti-oxidant effect of heme oxygenase-1 on cigarette smoke-induced vascular injury". Molecular Medicine Reports 12.2 (2015): 2481-2486.
Chicago
Yang, G., Li, Y., Wu, W., Liu, B., Ni, L., Wang, Z., Miao, S., Wang, L., Liu, C."Anti-oxidant effect of heme oxygenase-1 on cigarette smoke-induced vascular injury". Molecular Medicine Reports 12, no. 2 (2015): 2481-2486. https://doi.org/10.3892/mmr.2015.3722
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