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Lipopolysaccharide pretreatment inhibits LPS-induced human umbilical cord mesenchymal stem cell apoptosis via upregulating the expression of cellular FLICE-inhibitory protein

  • Authors:
    • Yu Sen Hou
    • Ling Ying Liu
    • Jia Ke Chai
    • Yong Hui Yu
    • Hong Jie Duan
    • Quan Hu
    • Hui Nan Yin
    • Yi He Wang
    • Shu Bo Zhuang
    • Jun Fan
    • Wan Li Chu
    • Li Ma
  • View Affiliations / Copyright

    Affiliations: Department of Burns and Plastic Surgery, The First Affiliated Hospital of PLA General Hospital, Beijing 100048, P.R. China
    Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 2521-2528
    |
    Published online on: May 4, 2015
       https://doi.org/10.3892/mmr.2015.3723
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Abstract

Mesenchymal stem cell (MSC)-based regenerative therapy is currently regarded as a novel approach with which to repair damaged tissues. However, the efficiency of MSC transplantation is limited due to the low survival rate of engrafted MSCs. Lipopolysaccharide (LPS) production is increased in numerous diseases and serves an essential function in the regulation of apoptosis in a variety of cell types. Previous studies have indicated that low‑dose LPS pretreatment contributes to cytoprotection. In the current study, LPS was demonstrated to induce apoptosis in human umbilical cord mesenchymal stem cells (hUCMSCs) via the activation of caspase, in a dose‑dependent manner. Low‑dose LPS pretreatment may protect hUCMSCs against apoptosis induced by high‑dose LPS, by upregulating the expression of cellular FADD‑like IL‑1β‑converting enzyme‑inhibitory protein (c‑FLIP). The results of the present study indicate that pretreatment with an appropriate concentration of LPS may alleviate high-dose LPS-induced apoptosis.
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View References

1 

Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, et al: Multilineage potential of adult human mesenchymal stem cells. Science. 284:143–147. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Ivanova-Todorova E, Bochev I, Mourdjeva M, Dimitrov R, et al: Adipose tissue-derived mesenchymal stem cells are more potent suppressors of dendritic cells differentiation compared to bone marrow-derived mesenchymal stem cells. Immunol Lett. 126:37–42. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Baksh D, Yao R and Tuan RS: Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells. 25:1384–1392. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, et al: Bone marrow cells regenerate infarcted myocardium. Nature. 410:701–705. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Troyer DL and Weiss ML: Wharton’s jelly-derived cells are a primitive stromal cell population. Stem Cells. 26:591–599. 2008. View Article : Google Scholar

6 

Lee PH, Lee JE, Kim HS, Song SK, Lee HS, Nam HS, et al: A randomized trial of mesenchymal stem cells in multiple system atrophy. Ann Neurol. 72:32–40. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Zhang Z, Lin H, Shi M, Xu R, Fu J, Lv J, Chen L, Lv S, et al: Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients. J Gastroenterol Hepatol. 27(Suppl 2): 112–120. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Dimarino AM, Caplan AI and Bonfield TL: Mesenchymal stem cells in tissue repair. Front Immunol. 4:2012013. View Article : Google Scholar : PubMed/NCBI

9 

Müller-Ehmsen J, Krausgrill B, Burst V, Schenk K, et al: Effective engraftment but poor mid-term persistence of mononuclear and mesenchymal bone marrow cells in acute and chronic rat myocardial infarction. J Mol Cell Cardiol. 41:876–884. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Burlacu A: Tracking the mesenchymal stem cell fate after transplantation into the infarcted myocardium. Curr Stem Cell Res Ther. 8:284–291. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Yin HN, Chai JK, Yao YM, Shen CA, et al: Effect of ubiquitin-proteasome pathway on inflammatory reaction in intestine and its barrier function in rats with postburn sepsis. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 18:649–652. 2006.In Chinese. PubMed/NCBI

12 

Caroff M and Karibian D: Structure of bacterial lipopolysaccharides. Carbohydr Res. 338:2431–2447. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Haase R, Kirschning CJ, Sing A, Schröttner P, et al: A dominant role of Toll-like receptor 4 in the signaling of apoptosis in bacteria-faced macrophages. J Immunol. 171:4294–4303. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Bannerman DD, Erwert RD, Winn RK and Harlan JM: TIRAP mediates endotoxin-induced NF-kappaB activation and apoptosis in endothelial cells. Biochem Biophys Res Commun. 295:157–162. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Jung DY, Lee H, Jung BY, Ock J, et al: TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: A critical role of IFN-beta as a decision maker. J Immunol. 174:6467–6476. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Vartanian KB, Stevens SL, Marsh BJ, et al: LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 plays a seminal role in mediating tolerance to ischemic injury. J Neuroinflammation. 8:1402011. View Article : Google Scholar : PubMed/NCBI

17 

Li WC, Jiang DM, Hu N, Qi XT, Qiao B and Luo XJ: Lipopolysaccharide preconditioning attenuates neuroapoptosis and improves functional recovery through activation of Nrf2 in traumatic spinal cord injury rats. Int J Neurosci. 123:240–247. 2013. View Article : Google Scholar

18 

Ha T, Hua F, Liu X, Ma J, McMullen JR, Shioi T, Izumo S, et al: Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism. Cardiovasc Res. 78:546–553. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Yao Y, Zhang F, Wang L, Zhang G, Wang Z, Chen J and Gao X: Lipopolysaccharide preconditioning enhances the efficacy of mesenchymal stem cells transplantation in a rat model of acute myocardial infarction. J Biomed Sci. 16:742009. View Article : Google Scholar : PubMed/NCBI

20 

Chetoui N, Boisvert M, Gendron S and Aoudjit F: Interleukin-7 promotes the survival of human CD4+ effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathway. Immunology. 130:418–426. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Peter ME: The flip side of FLIP. Biochem J. 382:e1–e3. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, et al: Inhibition of death receptor signals by cellular FLIP. Nature. 388:190–195. 1997. View Article : Google Scholar : PubMed/NCBI

23 

Perlman H, Pagliari LJ, Nguyen N, Bradley K, Liu H and Pope RM: The Fas-FasL death receptor and PI3K pathways independently regulate monocyte homeostasis. Eur J Immunol. 31:2421–2430. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Bai S, Liu H, Chen KH, Eksarko P, et al: NF-kappaB-regulated expression of cellular FLIP protects rheumatoid arthritis synovial fibroblasts from tumor necrosis factor alpha-mediated apoptosis. Arthritis Rheum. 50:3844–3855. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Han Y, Chai J, Sun T, Li D and Tao R: Differentiation of human umbilical cord mesenchymal stem cells into dermal fibroblasts in vitro. Biochem Biophys Res Commun. 413:561–565. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Schmidt M, Hupe M, Endres N, et al: The contact allergen nickel sensitizes primary human endothelial cells and keratinocytes to TRAIL-mediated apoptosis. J Cell Mol Med. 14:1760–1776. 2010. View Article : Google Scholar

27 

Chiou SH, Liu JH, Hsu WM, Chen SS, Chang SY, Juan LJ, et al: Upregulation of Fas ligand expression by human cytomegalovirus immediate-early gene product 2: A novel mechanism in cytomegalovirus-induced apoptosis in human retina. J Immunol. 167:4098–4103. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Yu LC, Flynn AN, Turner JR and Buret AG: SGLT-1-mediated glucose uptake protects intestinal epithelial cells against LPS-induced apoptosis and barrier defects: A novel cellular rescue mechanism? FASEB J. 19:1822–1835. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Piao X, Komazawa-Sakon S, Nishina T, Koike M, et al: c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. Sci Signal. 5:ra932012.PubMed/NCBI

30 

Yao YM, Chai JK and Sheng ZY: Diagnostic criterion and management of burn sepsis. Zhonghua Shao Shang Za Zhi. 19:65–66. 2003.In Chinese. PubMed/NCBI

31 

Pevsner-Fischer M, Morad V, Cohen-Sfady M, Rousso-Noori L, Zanin-Zhorov A, Cohen S, Cohen IR and Zipori D: Toll-like receptors and their ligands control mesenchymal stem cell functions. Blood. 109:1422–1432. 2007. View Article : Google Scholar

32 

Wang Y, Abarbanell AM, Herrmann JL, Weil BR, Manukyan MC, Poynter JA and Meldrum DR: TLR4 inhibits mesenchymal stem cell (MSC) STAT3 activation and thereby exerts deleterious effects on MSC-mediated cardioprotection. PLoS One. 5:e142062010. View Article : Google Scholar : PubMed/NCBI

33 

Choi KB, Wong F, Harlan JM, Chaudhary PM, Hood L and Karsan A: Lipopolysaccharide mediates endothelial apoptosis by a FADD-dependent pathway. J Biol Chem. 273:20185–20188. 1998. View Article : Google Scholar : PubMed/NCBI

34 

Karahashi H and Amano F: Changes of caspase activities involved in apoptosis of a macrophage-like cell line J774.1/JA-4 treated with lipopolysaccharide (LPS) and cycloheximide. Biol Pharm Bull. 23:140–144. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Hull C, McLean G, Wong F, Duriez PJ and Karsan A: Lipopolysaccharide signals an endothelial apoptosis pathway through TNF receptor-associated factor 6-mediated activation of c-Jun NH2-terminal kinase. J Immunol. 169:2611–2618. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Gidday JM: Cerebral preconditioning and ischaemic tolerance. Nat Rev Neurosci. 7:437–448. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Rosenzweig HL, Lessov NS, Henshall DC, Minami M, Simon RP and Stenzel-Poore MP: Endotoxin preconditioning prevents cellular inflammatory response during ischemic neuroprotection in mice. Stroke. 35:2576–2581. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Dirnagl U, Simon RP and Hallenbeck JM: Ischemic tolerance and endogenous neuroprotection. Trends Neurosci. 26:248–254. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Murry CE, Jennings RB and Reimer KA: Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation. 74:1124–1136. 1986. View Article : Google Scholar : PubMed/NCBI

40 

Thompson JW, Dave KR, Young JI and Perez-Pinzon MA: Ischemic preconditioning alters the epigenetic profile of the brain from ischemic intolerance to ischemic tolerance. Neurotherapeutics. 10:789–797. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Chen J and Simon R: Ischemic tolerance in the brain. Neurology. 48:306–311. 1997. View Article : Google Scholar : PubMed/NCBI

42 

Islam CF, Mathie RT, Dinneen MD, Kiely EA, Peters AM and Grace PA: Ischaemia-reperfusion injury in the rat kidney: The effect of preconditioning. Br J Urol. 79:842–847. 1997. View Article : Google Scholar : PubMed/NCBI

43 

Hickey E, Shi H, Van Arsdell G and Askalan R: Lipopolysaccharide-induced preconditioning against ischemic injury is associated with changes in toll-like receptor 4 expression in the rat developing brain. Pediatr Res. 70:10–14. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Wang ZJ, Zhang FM, Wang LS, Yao YW, Zhao Q and Gao X: Lipopolysaccharides can protect mesenchymal stem cells (MSCs) from oxidative stress-induced apoptosis and enhance proliferation of MSCs via Toll-like receptor (TLR)-4 and PI3K/Akt. Cell Biol Int. 33:665–674. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Krueger A, Baumann S, Krammer PH and Kirchhoff S: FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis. Mol Cell Biol. 21:8247–8254. 2001. View Article : Google Scholar : PubMed/NCBI

46 

Chang DW, Xing Z, Pan Y, Algeciras-Schimnich A, Barnhart BC, Yaish-Ohad S, Peter ME and Yang X: c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis. EMBO J. 21:3704–3714. 2002. View Article : Google Scholar : PubMed/NCBI

47 

Willems F, Amraoui Z, Vanderheyde N, Verhasselt V, et al: Expression of c-FLIP(L) and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide. Blood. 95:3478–3482. 2000.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hou YS, Liu LY, Chai JK, Yu YH, Duan HJ, Hu Q, Yin HN, Wang YH, Zhuang SB, Fan J, Fan J, et al: Lipopolysaccharide pretreatment inhibits LPS-induced human umbilical cord mesenchymal stem cell apoptosis via upregulating the expression of cellular FLICE-inhibitory protein. Mol Med Rep 12: 2521-2528, 2015.
APA
Hou, Y.S., Liu, L.Y., Chai, J.K., Yu, Y.H., Duan, H.J., Hu, Q. ... Ma, L. (2015). Lipopolysaccharide pretreatment inhibits LPS-induced human umbilical cord mesenchymal stem cell apoptosis via upregulating the expression of cellular FLICE-inhibitory protein. Molecular Medicine Reports, 12, 2521-2528. https://doi.org/10.3892/mmr.2015.3723
MLA
Hou, Y. S., Liu, L. Y., Chai, J. K., Yu, Y. H., Duan, H. J., Hu, Q., Yin, H. N., Wang, Y. H., Zhuang, S. B., Fan, J., Chu, W. L., Ma, L."Lipopolysaccharide pretreatment inhibits LPS-induced human umbilical cord mesenchymal stem cell apoptosis via upregulating the expression of cellular FLICE-inhibitory protein". Molecular Medicine Reports 12.2 (2015): 2521-2528.
Chicago
Hou, Y. S., Liu, L. Y., Chai, J. K., Yu, Y. H., Duan, H. J., Hu, Q., Yin, H. N., Wang, Y. H., Zhuang, S. B., Fan, J., Chu, W. L., Ma, L."Lipopolysaccharide pretreatment inhibits LPS-induced human umbilical cord mesenchymal stem cell apoptosis via upregulating the expression of cellular FLICE-inhibitory protein". Molecular Medicine Reports 12, no. 2 (2015): 2521-2528. https://doi.org/10.3892/mmr.2015.3723
Copy and paste a formatted citation
x
Spandidos Publications style
Hou YS, Liu LY, Chai JK, Yu YH, Duan HJ, Hu Q, Yin HN, Wang YH, Zhuang SB, Fan J, Fan J, et al: Lipopolysaccharide pretreatment inhibits LPS-induced human umbilical cord mesenchymal stem cell apoptosis via upregulating the expression of cellular FLICE-inhibitory protein. Mol Med Rep 12: 2521-2528, 2015.
APA
Hou, Y.S., Liu, L.Y., Chai, J.K., Yu, Y.H., Duan, H.J., Hu, Q. ... Ma, L. (2015). Lipopolysaccharide pretreatment inhibits LPS-induced human umbilical cord mesenchymal stem cell apoptosis via upregulating the expression of cellular FLICE-inhibitory protein. Molecular Medicine Reports, 12, 2521-2528. https://doi.org/10.3892/mmr.2015.3723
MLA
Hou, Y. S., Liu, L. Y., Chai, J. K., Yu, Y. H., Duan, H. J., Hu, Q., Yin, H. N., Wang, Y. H., Zhuang, S. B., Fan, J., Chu, W. L., Ma, L."Lipopolysaccharide pretreatment inhibits LPS-induced human umbilical cord mesenchymal stem cell apoptosis via upregulating the expression of cellular FLICE-inhibitory protein". Molecular Medicine Reports 12.2 (2015): 2521-2528.
Chicago
Hou, Y. S., Liu, L. Y., Chai, J. K., Yu, Y. H., Duan, H. J., Hu, Q., Yin, H. N., Wang, Y. H., Zhuang, S. B., Fan, J., Chu, W. L., Ma, L."Lipopolysaccharide pretreatment inhibits LPS-induced human umbilical cord mesenchymal stem cell apoptosis via upregulating the expression of cellular FLICE-inhibitory protein". Molecular Medicine Reports 12, no. 2 (2015): 2521-2528. https://doi.org/10.3892/mmr.2015.3723
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